Effects of cyclophosphamide on the immune system and disease resistance of Asian catfish

Kumari, Jaya; Sahoo, P.K.

doi:10.1016/j.fsi.2005.01.008

Cited by 101 publications

(60 citation statements)

References 34 publications

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“…In a comprehensive fish culture, fish are often afflicted by stressful environmental conditions leading to deterred immune response 46 . It is well documented that administration of dietary herbal immunostimulants can stimulate the non-specific immune response, elevate disease resistance and improve growth performance of fish and shell fish.…”

Section: Discussionmentioning

confidence: 99%

Limonia Acidissima L. (Wood Apple) as Feed Additive Enhanced Growth Performance, Immune Response and Disease Resistance of Indian Major Carp, Catla Catla (Ham.) Against Aeromonas Hydrophila Infection

Srinivasan¹,

Teepica²,

Maheshu³

et al. 2015

Int. Res. J. Pharm.

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Disease management has become prominent in aquaculture due to emergence of antibiotic resistant pathogens and overuse of chemotherapeutic agents. One among the developmental strategies to control disease outbreak is by enhancing the fish immunity using immunostimulants. The use of dietary herbal immunostimulants can improve the immune defence of fishes, providing resistance against infections. The present study evaluated the possible effects of Limonia acidissima L. fruit (wood apple) supplemented diets on the growth, innate immunity and disease resistance against Aeromonas hydrophila in Catla fish. Catla catla fingerlings (mean weight 5.0 ± 0.5 g) were separated into four groups and cultivated in 100-L tank. Each group was fed with diets supplemented with 0 g, 1.5 g, 3 g and 6 g per 100 g feed twice daily. Fish were examined for growth and innate immune parameters at 30 days interval up to 120 days. Results revealed that wood apple supplemented diets enhanced the growth and innate immune responses of Catla during the feeding trial. Growth performance, haematological parameters, biochemical parameters and immunological indices significantly (p < 0.05) increased in fish fed with experimental diets. The relative survival percentage after A. hydrophila challenge increased in fish fed with Limonia acidissima diet. Thus, the result suggested that fish fed Limonia acidissima Fruit supplemented diet enhanced growth, improved immune system and increased survival rate in C. catla fingerlings.

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Section: Discussionmentioning

confidence: 99%

Limonia Acidissima L. (Wood Apple) as Feed Additive Enhanced Growth Performance, Immune Response and Disease Resistance of Indian Major Carp, Catla Catla (Ham.) Against Aeromonas Hydrophila Infection

Srinivasan¹,

Teepica²,

Maheshu³

et al. 2015

Int. Res. J. Pharm.

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“…Numerous studies have supported the close relationship between the immune function of teleosts with their environment [33]. Until a fish adapts its specific immune system, it tends to rely on the non- Variations in haematological and immune parameters have been reported in Tench that exhibited greater alternative complement activity in winter in both male and female [34,35].…”

Section: Discussionmentioning

confidence: 99%

Haematological and innate immune responses in Puntius sarana: normal range and seasonal variation

2012

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A study was conducted to measure the normal ranges, seasonal and annual variations in haematological and immune parameters of juvenile healthy Puntius sarana (weighing 75–100 g) during three major seasons over two consecutive years. Significantly (P<0.05) lower serum myeloperoxidase and ceruloplasmin activities, superoxide production, plasma glucose level, packed cell volume and haemoglobin concentration were detected in winter as compared to the summer season. However, serum lysozyme activity, antiprotease activity, total erythrocyte count (TEC) and TLC profiles were consistent during all seasons. The reference intervals (25th–75th) of each parameter were estimated and a range was established. The annual changes in immune parameters with minimum and maximum values were measured and a significant variation was noticed in myeloperoxidase, antiprotease, total protein levels and TEC over two consecutive years. The lower levels in haematological and innate immune status of fish during winter possibly indicate a higher disease risk period for the species.

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“…Immunologic response in laboratory fish may be studied through the modulation of the immune system. The main in vivo models used in immunological studies are: stimulation of immune response, by injection or administration of immunostimulant molecules in the diet (Anderson, 1992;Siwicki et al, 1998;Sakai, 1999;Nayak, 2010;Hai, 2015); induction of inflammation by pathogens, antigens or inflammatory agents (Russell et al, 2006; ____________________ Corresponding editor: Fernando Vega Novoa et al, 2010;Novoa & Figueras, 2012); induction of immunosuppression by chronic stress (Yin et al, 1995;Tort et al, 1996;Sadhu et al, 2014); or administration of drugs by any ordinary process or via (Hickman-Davis et al, 2001;Walsh et al, 2002;Kumari & Sahoo, 2005;Cortes et al, 2013). This short trial aimed at evaluating existing protocols for inducement of immunosuppression by drugs in fish, adapted to slow release implant model, aiming the setup of controlled immunodeficiency state for further immunological studies.…”

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confidence: 99%

“…This procedure resulted in a slow release implant, based on the methodology described by Specker et al (1994). The immunosuppression drugs and dosage were cyclophosphamide (CYP), based on data reported by Kumari & Sahoo (2005) for Asian catfish (Clarias batrachus); dexamethasone (DX), based on data reported by Walsh et al (2002) for clearnose skates (Raja eglanteria), and hydrocortisone (HC), based on data reported by Specker et al (1994) for Atlantic salmon (Salmo salar). Blood samples were drawn by puncture of caudal vein (3.0 mL; heparinized syringes) from eight fish per treatment four days after administration of drugs.…”

mentioning

confidence: 99%

“…Blood samples were drawn by puncture of caudal vein (3.0 mL; heparinized syringes) from eight fish per treatment four days after administration of drugs. The sampling was performed on 4 th day after implant injection based on the time necessary to achieve immunosuppression, based on Kumari & Sahoo (2005), which used multiple drug injection over the days. In this trial, it was performed as a single injection in slow release implant model.…”

mentioning

confidence: 99%

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Preliminary assessment of slow release implant model for immunosuppression in juvenile pacu (Piaractus mesopotamicus)

Sabioni

Lorenz

Cyrino

2017

lajar

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ABSTRACT. Prolonged stress hampers immune function and lessens disease resistance of fish, causing economic losses. Attention is thus been centered in the study of fish immunology. The main 'in vivo' models used in immunological studies are: stimulation of immune response (by immunostimulant molecules); induction of inflammation; induction of immunosuppression by chronic stress; or administration of drugs. This trial aimed at evaluating existing protocols for immunosuppression by drugs in fish, adapted to slow release implants model, using hydrogenated vegetable fat (HVF), with the intention of set a controlled immunodeficiency state model for advanced studies. The implant model was not efficient in reducing the immune response in a controlled manner. Evidence of self, down-regulation in fish immune system was found in implanted fish, what should be further investigated using molecular tools.

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Effects of cyclophosphamide on the immune system and disease resistance of Asian catfish

Cited by 101 publications

References 34 publications

Limonia Acidissima L. (Wood Apple) as Feed Additive Enhanced Growth Performance, Immune Response and Disease Resistance of Indian Major Carp, Catla Catla (Ham.) Against Aeromonas Hydrophila Infection

Limonia Acidissima L. (Wood Apple) as Feed Additive Enhanced Growth Performance, Immune Response and Disease Resistance of Indian Major Carp, Catla Catla (Ham.) Against Aeromonas Hydrophila Infection

Haematological and innate immune responses in Puntius sarana: normal range and seasonal variation

Preliminary assessment of slow release implant model for immunosuppression in juvenile pacu (Piaractus mesopotamicus)

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