Effects of cyclic AMP, cyclic GMP and IP3 intracellularly injected into the identifiable Achatina giant neurones

Liu, Guo Jun; Takeuchi, Hiroshi

doi:10.1016/0742-8413(93)90135-8

Cited by 2 publications

(4 citation statements)

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“…The 5-HT (100 μM) depolarizes the quiescent d-RPLN and triggers burst of APs. Also, the intracellular cyclic adenosine monophosphate (cAMP) evokes such an activity, while cyclic guanosine monophosphate (cGMP) only depolarizes d-RPLN without triggering APs (Liu and Takeuchi, 1993). The somatic application of inositol trisphosphate (IP 3 ) hyperpolarizes the membrane potential.…”

Section: Molluscan Heartsmentioning

confidence: 99%

“…In Achatina, the APs of d-VLN evoke inhibitory–excitatory junction potentials (I–EJPs) in the myocardium (Zhuravlev et al, 2001). Similar neuron in ventral surface of visceral ganglion is designated as v-VLN (Liu and Takeuchi, 1993). The v-VLN is either quiescent or generates APs, and somatic injection of 10 mM cGMP evokes a high frequency burst lasting up to 60 s, which is ceased by sudden repolarization.…”

Section: Excitation Of Heartmentioning

confidence: 99%

“…The TAN1-3 are situated next to each other close to the visceral ganglion’s border either in a circle or one after the other (Furukawa and Kobayashi, 1987a; Zhuravlev et al, 1994; Zhuravlev et al, 2002). The somatic application of IP 3 hyperpolarizes the TAN, but cAMP and cGMP reversibly depolarize it and evoke burst of APs (Liu and Takeuchi, 1993). The soma of TANs are located in right parietal ganglion; however, the neural branches of at least one of them reach the left parietal ganglion via visceral one and the axonal terminals are found in the following nerves: an , lpn , lppn , and rpn (Isao, 1980).…”

Section: Excitation Of Heartmentioning

confidence: 99%

“…The β-hydroxyglutamic acid inhibits PON by hyperpolarizing the membrane potential and subsequently (depending on the concentration) either by increasing the rate of periodic oscillations or blocking APs (Takeuchi et al, 1975). Using a double-barreled pipette for the simultaneous recording of neuronal activity and somatic injections, it was demonstrated that 10 mM cAMP triggers the burst of APs in quiescent PON (Liu and Takeuchi, 1993). The cGMP at identical concentration depolarized this neuron, but the threshold for APs was not reached; IP 3 hyperpolarized the PON.…”

Section: Excitation Of Heartmentioning

confidence: 99%

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The neuronal control of cardiac functions in Molluscs

Kodirov

2011

Comparative Biochemistry and Physiology Part A: Molecular &

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In this manuscript, I review the current and relevant classical studies on properties of the Mollusca heart and their central nervous system including ganglia, neurons, and nerves involved in cardiomodulation. Similar to mammalian brain hemispheres, these invertebrates possess symmetrical pairs of ganglia albeit visceral (only one) ganglion and the parietal ganglia (the right ganglion is bigger than the left one). Furthermore, there are two major regulatory drives into the compartments (pericard, auricle, and ventricle) and cardiomyocytes of the heart. These are the excitatory and inhibitory signals that originate from a few designated neurons and their putative neurotransmitters. Many of these neurons are well-identified, their specific locations within the corresponding ganglion are mapped, and some are termed as either heart excitatory (HE) or inhibitory (HI) cells. The remaining neurons are classified as cardio-regulatory, and their direct and indirect actions on the heart’s function have been documented. The cardiovascular anatomy of frequently used experimental animals, Achatina, Aplysia, Helix, and Lymnaea is relatively simple. However, as in humans, it possesses all major components including even trabeculae and atrio-ventricular valves. Since the myocardial cells are enzymatically dispersible, multiple voltage dependent cationic currents in isolated cardiomyocytes are described. The latter include at least the A-type K+, delayed rectifier K+, TTX-sensitive Na+, and L-type Ca2+ channels.

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Section: Molluscan Heartsmentioning

confidence: 99%

Section: Excitation Of Heartmentioning

confidence: 99%