Effects of Custodiol-N, a novel organ preservation solution, on ischemia/reperfusion injury

Loganathan, Sivakkanan; Radovits, Tamás; Hirschberg, Kristóf; Korkmaz, Sevil; Koch, Andrea; Kretzler, Matthias; Szabó, Gábor

doi:10.1016/j.jtcvs.2009.09.034

Cited by 40 publications

(30 citation statements)

References 22 publications

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“…LK 614 also showed strong protection in the current study. The new preservation solution, as base solution (N46) and supplemented by iron chelators (Custodiol-N), showed largely improved liver and heart preservation in different experimental studies [20,23,24], and will, based on the encouraging results described here, soon be tested in an experimental model of lung transplantation.…”

Section: Discussionmentioning

confidence: 81%

Cold-induced injury to lung epithelial cells can be inhibited by iron chelators — implications for lung preservation☆

Pizanis

Gillner

Kamler

et al. 2011

European Journal of Cardio-Thoracic Surgery

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Section: Discussionmentioning

confidence: 81%

Cold-induced injury to lung epithelial cells can be inhibited by iron chelators — implications for lung preservation☆

Pizanis

Gillner

Kamler

et al. 2011

European Journal of Cardio-Thoracic Surgery

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“…As shown in earlier studies, a fundamental pathway for cardiac damage during reperfusion includes marked increases in the amount of superoxide anion, hydrogen peroxide, and possibly singlet oxygen production [20]. In line with these findings, it has been demonstrated that a Bretschneider’s solution, developed as a cardioplegic solution in routine cardiac surgery, could effectively reduce energy requirements and prevent damages during reperfusion, due its role as a strong reducing agent of hydroxyl radicals and reactive oxygen species (ROS), leading to improved myocardial protection via controlling cellular oxidative stress levels [21, 22]. Therefore, preventing or at least to controlling increases in the oxidative stress levels of donor hearts during cold storage seems to be a crucial part of heart transplantation in cardiac surgery.…”

Section: Discussionmentioning

confidence: 95%

Improvement of Functional Recovery of Donor Heart Following Cold Static Storage with Doxycycline Cardioplegia

et al. 2013

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Injury to the donor heart during cold preservation has a negative impact on graft survival before transplantation. This study aims to examine whether doxycycline, known as an MMP-2 inhibitor, has a positive effect on donor heart preservation via its antioxidant action when added to standard preservation solution. Hearts were obtained from 3-month-old male Wistar rats and randomly divided into three groups: hearts stored for 1 h at 4 °C (1) with doxycycline preservation solution (DOX cardioplegia) with low Ca2+; (2) with standard cardioplegia with low Ca2+; and (3) unstored hearts. All hearts were perfused in working mode, arrested at 37 °C, removed from the perfusion system, reattached in Langendorff perfusion system, and converted to working mode for 1 h. At the end of the storage period, hearts preserved in DOX cardioplegia had significantly less weight gain than those preserved in the standard cardioplegia. DOX cardioplegia-induced preservation resulted in significantly higher heart rates and better recovery quality during reperfusion in aortic flow compared to the standard cardioplegia group. Recovery in the left ventricular function and Lambeth Convention Arrhythmia scores during 1 h reperfusion were also significantly better in the DOX cardioplegia group. Biochemical data showed that DOX cardioplegia prevented an increase in MMP-2 activity and blocked apoptosis through increased activity of the pro-survival kinase Akt in the donor heart homogenates. DOX cardioplegia also led to a balanced oxidant/antioxidant level in the heart homogenates. This is the first study to report that cardioplegia solution containing doxycycline provides better cardioprotection via the preservation of heart function, through its role in controlling cellular redox status during static cold storage.

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“…It is worth nothing that normal preoperative PVR does not rule out increased PVR and acute RV failure after HTx. Organ preservation and cardiopulmonary bypass also have deleterious effects on ventricular function [22][23][24] . The previous common practice of using oversized donors for recipients with PH has been found unnecessary 25 .…”

Section: Discussionmentioning

confidence: 99%

Impact of pulmonary hypertension on early hemodynamics, morbidity and mortality after orthotopic heart transplantation. A single center study

Bedáňová

Orban²,

Vrsanský³

et al. 2013

BIOMED PAP

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Aims.To determine the effect of pre-existing pulmonary hypertension (PHT) on early hemodynamics, morbidity and mortality after heart transplantation (HTx). Methods. Data were prospectively collected from 149 patients, who underwent HTx between January 2000 and December 2007. The subjects were divided into 3 groups: Group A (n=84) without PTH, group B (n=50) with mild to moderate PTH and group C (n=15) with severe PTH. We studied hemodynamic profile, tricuspid valve regurgitation (TR), incidence of acute cellular rejections (AR), infections, duration of hospitalization, 30-day mortality and a longterm survival. Results. Baseline characteristics were similar in all groups. Using vasodilator treatment PVR was successfully brought down to normal range 2.5 ± 0.6 Wood' units (WU) on the day 1 following the surgery in all groups. Over 80% of patients were treated in Group C, 32% in Group A and 46% in Group B. There was no significant difference in the severity of TR among the 3 groups early after HTx (severe TR was observed in 46%, 54%, 33%, respectively). There was no significant difference in incidence of AR (G ≥ 2 Banff classification) (23%, 23%, 33%, respectively), infections (28%, 32%, 33%, respectively) or duration of hospitalization (30, 30, 28 days, respectively). There was no correlation between pre-transplant PHT and 30-day mortality or a long-term survival. Conclusions. In our cohort, PHT dropped very quickly after HTx, and was not associated with acute right heart failure following the surgery. Reversible PTH does not have a negative impact on short-or long-term survival after HTx.

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Effects of Custodiol-N, a novel organ preservation solution, on ischemia/reperfusion injury

Abstract: Custodiol-N improves myocardial and endothelial function during the critical phase of reperfusion after heart transplantation.

Cited by 40 publications

References 22 publications

Cold-induced injury to lung epithelial cells can be inhibited by iron chelators — implications for lung preservation☆

Cold-induced injury to lung epithelial cells can be inhibited by iron chelators — implications for lung preservation☆

Improvement of Functional Recovery of Donor Heart Following Cold Static Storage with Doxycycline Cardioplegia

Impact of pulmonary hypertension on early hemodynamics, morbidity and mortality after orthotopic heart transplantation. A single center study

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