Effects of current smoking and smoking discontinuation on renal function and proteinuria in the general population

Halimi, Jean‐Michel; Giraudeau, Bruno; Vol, Sylviane; Cacès, E; Nivet, Hubert; Lebranchu, Yvon; Tichet, Jean

doi:10.1046/j.1523-1755.2000.00284.x

Cited by 151 publications

(119 citation statements)

References 35 publications

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“…Halimi et al 7 reported a high Ccr or large glomerular filtration rate (GFR) in smokers in a general French population, similar to our findings. Briganti et al, 8 however, reported a decrease in Ccr related to lifelong accumulated cigarette consumption.…”

supporting

confidence: 91%

“…Nicotine causes constant renal vasodilatation by release of nitric oxide and natriuretic peptides, with the repeated renal vasodilatations causing chronic glomerular hyperfiltration. 7 Or, transient renal hypoperfusion is caused by each cigarette use, and the repeated hypoperfusion may damage some glomeruli, and this in turn induces hyperfiltration in the remnant glomeruli. Normal or high GFR in smokers hence reflects a compensated phase, but which would eventually deteriorate to the renal failure phase.…”

mentioning

confidence: 99%

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Alcohol and cigarette consumption, renal function and blood pressure in middle-aged healthy men

et al. 2007

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supporting

confidence: 91%

mentioning

confidence: 99%

Alcohol and cigarette consumption, renal function and blood pressure in middle-aged healthy men

et al. 2007

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“…In a cross-sectional study from France, smoking was not associated with decreased creatinine clearance (40). By contrast, a cross-sectional study from Australia (41) found that smoking was independently associated with renal impairment and proteinuria.…”

Section: Discussionmentioning

confidence: 85%

Risk Factors for Development of Decreased Kidney Function in a Southeast Asian Population

Domrongkitchaiporn¹,

Sritara²,

Kitiyakara³

et al. 2005

Journal of the American Society of Nephrology

190

137

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End-stage kidney disease has become an increasing burden in all regions of the world. However, limited epidemiologic data on chronic kidney disease in Southeast Asian populations are available. Therefore, a cohort study over a period of 12 yr (1985 to 1997) in 3499 employees of the Electric Generation Authority of Thailand, aged 35 to 55 yr, was conducted to determine the prevalence of decreased kidney function and risk factors associated with future development of decreased kidney function. The prevalence of decreased kidney function (GFR <60 ml/min) increased from 1.7% (95% confidence interval [CI], 1.3 to 2.1) in 1985 to 6.8% (95% CI, 5.7 to 7.9) in 1997, and the prevalence of elevated serum creatinine was 6.1% (95% CI, 5.3 to 6.9) and 16.9% (95% CI, 15.3 to 18.5) in 1985 and 1997 surveys, respectively. The adjusted odds ratio for future development of decreased kidney function was 2.57 (1.0 to 6.81) for systolic hypertension (>159 mmHg), 1.82 (1.12 to 2.98) for hyperuricemia (>6.29 mg/dl), 1.68 (1.02 to 2.77) for elevated body mass index (>24.9 kg/m 2 ) compared with subjects with systolic BP <140 mmHg, serum uric acid <4.5 mg/dl, and body mass index 20.8 to 22.8 kg/m 2 . The rising prevalence of decreased kidney function in this population resulted mainly from the increasing prevalence of the risk factors in the population. Screening to detect decreased kidney function and early intervention to modify the associated risk factors should be considered in otherwise healthy individuals. Future studies are also necessary to determine whether implementation of these measures results in a reduction of ESRD incidence in the population.

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“…After adjustment for potential confounding factors, current smokers who smoked Ͻ20 or Ͼ20 cigarettes per day, respectively, had an elevated risk for high-normal urine albumin concentration (relative risk [RR] 1.33 and 1.98, respectively). Halimi et al (16) studied 28,409 volunteers from the general population. They found that current and former smokers had a marked risk for macroalbuminuria (adjusted RR 3.26 and 2.69, respectively), indicating nonreversible kidney damage related to smoking.…”

Section: General Populationmentioning

confidence: 99%

Smoking

Orth

Hallan²

2008

Clinical Journal of the American Society of Nephrology

253

174

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Although it is beyond any doubt that smoking is the number one preventable cause of death in most countries, smoking as an independent progression factor in renal disease has been questioned against the background of evidence-based criteria. This is because information from large, randomized, prospective studies that investigate the effects of smoking on renal function in healthy individuals as well as in patients with primary or secondary renal disease are lacking. Since 2003, a substantial number of clinical and experimental data concerning the adverse renal effects of smoking have been published, including large, prospective, population-based, observational studies. These more recent data together with evidence from experimental studies clearly indicate that smoking is a relevant risk factor, conferring a substantial increase in risk for renal function deterioration. This review summarizes the present knowledge about the renal risks of smoking as well as the increased cardiovascular risk caused by smoking in patients with chronic kidney disease. The conclusion is that smoking is an important renal risk factor, and nephrologists have to invest more efforts to motivate patients to stop smoking.

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Effects of current smoking and smoking discontinuation on renal function and proteinuria in the general population

Cited by 151 publications

References 35 publications

Alcohol and cigarette consumption, renal function and blood pressure in middle-aged healthy men

Alcohol and cigarette consumption, renal function and blood pressure in middle-aged healthy men

Risk Factors for Development of Decreased Kidney Function in a Southeast Asian Population

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