Effects of curcumin/turmeric supplementation on the liver enzymes, lipid profiles, glycemic index, and anthropometric indices in non‐alcoholic fatty liver patients: An umbrella meta‐analysis

Molani‐Gol, Roghayeh; Dehghani, Azadeh; Rafraf, Maryam

doi:10.1002/ptr.8051

Cited by 4 publications

(3 citation statements)

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“…Cancer is a significant health issue, and although early diagnosis and targeted therapy have markedly reduced mortality, cancer drug resistance and drug side effects are still clinical problems that need to be resolved ( 106 ). Curcumin is a natural compound that has been used for the treatment of numerous types of diseases, such as Alzheimer's disease, fatty liver and cancer ( 53 , 107 , 108 ). Of note, curcumin has a dual role in oncological and non-oncologic diseases.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant curcumin induces oxidative stress to kill tumor cells (Review)

Hu,

Cheng,

et al. 2023

Oncol Lett

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Curcumin is a plant polyphenol in turmeric root and a potent antioxidant. It binds to antioxidant response elements for gene regulation by nuclear factor erythroid 2-related factor 2, thereby suppressing reactive oxygen species (ROS) and exerting anti-inflammatory, anti-infective and other pharmacological effects. Of note, curcumin induces oxidative stress in tumors. It binds to several enzymes in tumors, such as carbonyl reductases, glutathione S-transferase P1 and nicotinamide adenine dinucleotide phosphate to induce mitochondrial damage, increase ROS production and ultimately induce tumor cell death. However, the instability and poor pharmacokinetic profile of curcumin in vivo limit its clinical application. Therefore, the effects of curcumin in vivo may be enhanced through its combination with drugs, derivative development and nanocarriers. In the present review, the mechanisms of curcumin that induce tumor cell death through oxidative stress are discussed. In addition, the methods used to enhance the antitumor activity of curcumin are described. Finally, the existing knowledge on the functions of curcumin in tumors, particularly in terms of oxidative stress, are summarized to facilitate future curcumin research.

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Section: Discussionmentioning

confidence: 99%

Antioxidant curcumin induces oxidative stress to kill tumor cells (Review)

Hu,

Cheng,

et al. 2023

Oncol Lett

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“…В польском метаанализе (14 статей) [37] показано, что использование добавок куркумина или куркумина с изменениями в диете, образе жизни и (или) физической активности у пациентов с НАЖБП привело к статистически значимым положительным изменениям в уровнях АЛТ, АСТ, инсулина в крови натощак, ТГ и ОХС, резистентности к инсулину (HOMA-IR) и окружности талии. Зонтичный метаанализ иранских ученых [38], опубликованный в 2024 г., был направлен на оценку имеющихся данных и предоставление точной оценки общего воздействия куркумина/куркумы на пациентов с НАЖБП. Авторами был проведен поиск в базах данных Web of Science, Scopus, PubMed, ScienceDirect и Google Scholar до марта 2023 г. Анализ результатов 11 метаанализов и 99 РКИ с общим участием 5546 участников показал, что добавление куркумина/куркумы достоверно снижает АСТ (P = 0,0001), АЛТ (P = 0,014), инсулинорезистентность HOMA-IR (P = 0,0001), ИМТ (P = 0,0001) и окружность талии (Р = 0,001) при сопоставлении с группой сравнения.…”

Section: куркумаunclassified

“…Авторами был проведен поиск в базах данных Web of Science, Scopus, PubMed, ScienceDirect и Google Scholar до марта 2023 г. Анализ результатов 11 метаанализов и 99 РКИ с общим участием 5546 участников показал, что добавление куркумина/куркумы достоверно снижает АСТ (P = 0,0001), АЛТ (P = 0,014), инсулинорезистентность HOMA-IR (P = 0,0001), ИМТ (P = 0,0001) и окружность талии (Р = 0,001) при сопоставлении с группой сравнения. Полученные данные свидетельствуют о благоприятном воздействии добавок куркумина/куркумы у пациентов с НАЖБП, таких как улучшение функции печени, снижение резистентности к инсулину и снижение показателей общего и центрального ожирения [38]. В иранском метаанализе 2024 г.…”

Section: куркумаunclassified

Biliary tract dysfunctions: Possibilities of combined drugs of plant origin as advantage therapy

Trukhan,

Rozhkova,

Samoilova

et al. 2024

Medicinskij sovet

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Introduction. Non-alcoholic fatty liver disease (NAFLD) is caused by excess accumulation of fats in hepatocytes. An increasing percentage of adipose tissue is associated with chronic inflammation and developing oxidative stress. These pathological conditions can lead to the progression of steatosis to steatohepatitis with the further development of fibrosis and cirrhosis.Aim. To evaluate the indicators of lipid peroxidation and antioxidant defence factors in steatosis and steatohepatitis in patients with NAFLD.Materials and methods. During the work, 116 patients with NAFLD were examined, of which 65 had steatosis, and 51 had steatohepatitis. The study of biochemical markers of metabolism of proteins, fats and carbohydrates was performed on a Mindray BS-380 biochemical analyzer. The indicators of the LPO-AOD system (MDA, SOD, catalase, ceruloplasmin) were assessed using spectrophotometric methods. Statistical data processing was carried out in the STATISTICA and SPSS 26 programs using nonparametric tests.Results. Patients with steatohepatitis had more severe dyslipidemia, blood triglyceride, total cholesterol levels and LDL were significantly higher (p > 0.05). Impaired cholesterol metabolism was reflected by a high atherogenic index of 3.46. In patients with steatosis, changes in the lipid profile were less pronounced. No disturbances in protein and carbohydrate metabolism were detected. Increased levels of liver markers were noted only in patients with steatohepatitis. The change in the balance in the LPO- AOD system was more pronounced in patients with steatohepatitis; they had a high level of MDA, a high concentration of catalase; in patients with steatosis, only a decrease in the level of MDA and an increase in the level of ceruloplasmin were noted.Conclusion. Dyslipidemia, hepatocyte cytolysis and liver fibrosis are detected in patients with steatohepatitis. Disturbances in the LPO-AOD system have been identified in both forms of NAFLD, but in steatosis they are compensated. In steatohepatitis, disturbances in “LPO-AOD” in the form of an increase in pro-oxidants and a decrease in antioxidants cause the development of oxidative stress.

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Does curcumin improve liver enzymes levels in nonalcoholic fatty liver disease? A systematic review, meta‐analysis, and meta‐regression

Aragón‐Vela,

Sánchez‐Oliver,

Huertas

et al. 2024

Phytotherapy Research

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The aim of this meta‐analysis is to investigate the sources of heterogeneity in randomized clinical trials examining the effects of curcumin supplementation on liver aminotransferases in subjects with nonalcoholic fatty liver disease (NAFLD). We conducted a systematic search of the PubMed, SCOPUS, and Web of Science databases for randomized clinical trials and identified 15 studies (n = 835 subjects). We used random‐effects models with DerSimonian‐Laird methods to analyze the serum levels of alanine aminotransferase and aspartate aminotransferase enzymes. Our results indicate that curcumin did not affect serum alanine aminotransferase, but it did reduce aspartate aminotransferase levels. Notably, both outcomes showed high heterogeneity (p < 0.01). Subgroup analysis revealed that adding piperine to curcumin did not benefit aminotransferase levels in NAFLD patients. Additionally, we found a negative correlation between the duration of the intervention and the relative (mg/kg/day) curcumin dose with the reduction in liver aminotransferases. In summary, the sources of heterogeneity identified in our study are likely attributed to the duration of the intervention and the relative dose of curcumin. Consequently, longer trials utilizing high doses of curcumin could diminish the positive impact of curcumin in reducing serum levels of aminotransferases in patients with NAFLD.

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Effects of curcumin/turmeric supplementation on the liver enzymes, lipid profiles, glycemic index, and anthropometric indices in non‐alcoholic fatty liver patients: An umbrella meta‐analysis

Cited by 4 publications

References 90 publications

Antioxidant curcumin induces oxidative stress to kill tumor cells (Review)

Antioxidant curcumin induces oxidative stress to kill tumor cells (Review)

Biliary tract dysfunctions: Possibilities of combined drugs of plant origin as advantage therapy

Does curcumin improve liver enzymes levels in nonalcoholic fatty liver disease? A systematic review, meta‐analysis, and meta‐regression

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