Effects of curcumin supplementation on vitamin D levels in women with premenstrual syndrome and dysmenorrhea: a randomized controlled study

Abstract

Background Vitamin D has an established role in female reproduction. There is also evidence for an association between vitamin D levels and menstrual problems such as premenstrual syndrome (PMS) and dysmenorrhea. Curcumin, is a bioactive polyphenol constituent of turmeric, that can potentially interact with vitamin D receptors and its molecular targets. This study evaluated the effects of curcumin on vitamin D levels in young women with PMS and dysmenorrhea. Methods In this randomized, triple-blind, placebo-controlled trial, women with PMS and dysmenorrhea were divided randomly into experimental and control groups to receive one capsule (500 mg of curcuminoid+ 5 mg piperine, or placebo) daily, from approximately 7 days before until 3 days after menstruation for three consecutive menstrual cycles. Serum vitamin D levels, renal function, and liver enzymes were also measured before and after intervention. Results A total of 76 subjects (38 in each group) were recruited into the trial. Curcumin significantly increased the median (IQR) serum levels of vitamin D [from 12.8 ng/ml (7.0–24.6) to 16.2 ng/ml (6.4–28.8); P = 0.045], compared with placebo [from 18.6 ng/ml (2.2–26.8) to 21.3 ng/ml (5.2–27.1); P = 0.17]. Serum levels of aspartate aminotransferase and direct bilirubin were reduced by the end of trial in the curcumin group (p < 0.05), but did not change significantly in the control group (p > 0.05). Finally, no significant differences in levels of fasting blood glucose were detected between curcumin and placebo groups. Conclusion Curcumin supplementation in women with PMS and dysmenorrhea led to a significant improvement of vitamin D, liver function enzyme test, but did not affect blood glucose. Trial registration The trial was registered on Iranian Registry of Clinical Trials registry (Trial ID: IRCT20191112045424N1 on 23 January 2020; available at https://www.irct.ir).

Vitamin D and curcumin-loaded PCL nanofibrous for engineering osteogenesis and immunomodulatory scaffold

“…According to another study, Cur can also decrease the IL-1α induced expression of RANKL in BMSCs, leading to the suppression of osteclastogenesis and inducing apoptosis of osteoclasts (Ozaki et al, 2000;Bharti et al, 2004;Gu et al, 2012;Sahebkar et al, 2016). Moreover, some studies have confirmed the relationship between curcumin and Vit D. The effectiveness of curcumin in improving Vit D deficiency, especially in women with PMS and dysmenorrhea (Arabnezhad et al, 2022). Therefore, in this study, we have utilized the electrospinning method to fabricate a nanofibrous scaffold doped with Vit D and Cur, as shown in Figure 1.…”

Role of Inflammation, Oxidative Stress, and Mitochondrial Changes in Premenstrual Psychosomatic Behavioral Symptoms with Anti-Inflammatory, Antioxidant Herbs, and Nutritional Supplements

“…Arabnezhad et al [ 51 ] reported that curcumin improves serum vitamin D levels. Xin et al [ 104 ] described that curcumin induces overexpression of vitamin D receptor (VDR) in osteoblasts and femurs probably involved in the protective effect of curcumin on bone loss created by microgravity although curcumin administration has no considerable effect on serum 1,25-(OH)2D3 concentration.…”

A Systematic Review and Meta-Analysis of Premenstrual Syndrome with Special Emphasis on Herbal Medicine and Nutritional Supplements

“…We excluded the following RCTs from the meta-analysis as reasoned: Arabnezhad et al (2022) [1] included a PSST study only before the intervention. Maskani et al (2020) [31] and Ozgoli (2011) [32] were written in Persian Language, and the data for symptoms were presented as percentages and number.…”

“…Premenstrual somatic and psycho-behavioural symptoms are categorized by a cyclic pattern that is obvious within the luteal phase [1], and they significantly affect quality of life with more frequent visits to hospitals parenting problems, decreased work productivity, and impaired individual and societal relationships [2][3][4]. It is a common and recurrent gynaecological problem [1], and 20-30% of reproductive-age women experience clinically significant premenstrual syndrome (PMS) symptoms [5]. The main psychological range of PMS symptoms includes anxiety and depression [3,6].…”

“…The aetiology of PMS is unclear; hence, definitive treatment is not available. However, several possible treatments have been established based on symptomatic relief [1,6]. Despite a rational success rate of pharmacotherapies (GnRH agonists OCP, selective serotonin reuptake inhibitors benzodiazepines) and non-pharmacological management (aerobic exercise, cognitive behavioural therapy, reduction in caffeine intake, education, and increased calcium and carbohydrate intake) for PMS, these therapies have considerable side effects [5,7,8].…”