Effects of curcumin supplementation on blood glucose, insulin resistance and androgens in patients with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial

Heshmati, Javad; Moini, Ashraf; Sepidarkish, Mahdi; Morvaridzadeh, Mojgan; Salehi, Masoud; Palmowski, Andriko; Mojtahedi, Maryam Farid; Shidfar, Farzad

doi:10.1016/j.phymed.2020.153395

Cited by 61 publications

(71 citation statements)

References 39 publications

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“…With regard to lipid metabolism, Curcumin may have promising effects in improving hyperandrogenism, though this is not demonstrated in the present study because meta-analysis, which evaluates and reports the influence of curcumin on thecal androgen production, is not performed due to the limited number of studies. In the study by Heshmati et al, the plasma levels of dehydroepiandrosterone (DHEA) are significantly reduced in patients taking curcumin compared to those taking placebo for 12 weeks [41]. This observation is likely attributed to the downregulation of the activity of cytochrome P450c17.…”

Section: Discussionmentioning

confidence: 99%

“…The dosing regimen of curcumin ranges from 500 mg once per day [40] to 500 mg three times per day [41]. Maltodextrin is used as placebo in one study [41], starch is used in another [40], and the other does not specify what consists of placebo [42]. The duration of therapy ranges from 6 weeks [42] to 12 weeks [40,41].…”

Section: Study Characteristics and Risk Of Bias Assessmentmentioning

confidence: 99%

“…Maltodextrin is used as placebo in one study [41], starch is used in another [40], and the other does not specify what consists of placebo [42]. The duration of therapy ranges from 6 weeks [42] to 12 weeks [40,41]. The diagnosis of PCOS is based on Rotterdam criteria in all the included studies [3].…”

Section: Study Characteristics and Risk Of Bias Assessmentmentioning

confidence: 99%

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Effects of Curcumin on Glycemic Control and Lipid Profile in Polycystic Ovary Syndrome: Systematic Review with Meta-Analysis and Trial Sequential Analysis

Chien

Chang

et al. 2021

Nutrients

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The therapeutic effects of curcumin for polycystic ovary syndrome (PCOS) remain inconclusive. The present study aims to evaluate the effects of curcumin on glycemic control and lipid profile in patients with PCOS. PubMed, Embase, Scopus, Web of Science, and Cochrane Library were searched from the inception through 28 November 2020. Randomized control trials (RCTs), which enrolled adult patients with PCOS, compared curcumin with placebo regarding the glycemic control and lipid profile, and reported sufficient information for performing meta-analysis, were included. Three RCTs were included. Curcumin significantly improves fasting glucose (mean difference (MD): −2.77, 95% confidence interval (CI): −4.16 to −1.38), fasting insulin (MD: −1.33, 95% CI: −2.18 to −0.49), Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) (MD: −0.32, 95% CI: −0.52 to −0.12), and quantitative insulin sensitivity check index (QUICKI) (MD: 0.010, 95% CI: 0.003–0.018). It also significantly improves high-density lipoprotein (MD: 1.92, 95% CI: 0.33–3.51) and total cholesterol (MD: −12.45, 95% CI: −22.05 to −2.85). In contrast, there is no statistically significant difference in the improvement in low-density lipoprotein (MD: −6.02, 95% CI: −26.66 to 14.62) and triglyceride (MD: 8.22, 95% CI: −26.10 to 42.53) between curcumin and placebo. The results of the fasting glucose, fasting insulin, HOMA-IR, QUICKI, and total cholesterol are conclusive as indicated by the trial sequential analysis. Curcumin may improve glycemic control and lipid metabolism in patients with PCOS and metabolic abnormality without significant adverse effects. Further studies are advocated to investigate the potential effects of curcumin on hyperandrogenism.

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Section: Discussionmentioning

confidence: 99%

Section: Study Characteristics and Risk Of Bias Assessmentmentioning

confidence: 99%

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Effects of Curcumin on Glycemic Control and Lipid Profile in Polycystic Ovary Syndrome: Systematic Review with Meta-Analysis and Trial Sequential Analysis

Chien

Chang

et al. 2021

Nutrients

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“…The mechanisms of insulin resistance are very complex, they are usually related to obesity, metabolic abnormalities, gene expression and so on. [ 8 ] Therefore, reducing body weight, improving glucose and lipid metabolism, inhibiting sex hormone secretion and inflammatory response are all conducive to alleviating insulin resistance, [ 9 , 10 ] which is of great significance for increasing ovulation rate and pregnancy rate in women with PCOS.…”

Section: Introductionmentioning

confidence: 99%

Effects of atorvastatin on the insulin resistance in women of polycystic ovary syndrome

Chen¹,

Zheng²

2021

Medicine

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Background: Atorvastatin treatment has been suggested as a therapeutic method for women with polycystic ovary syndrome (PCOS) in many clinical studies. Nonetheless, the effects of atorvastatin on insulin resistance in PCOS patients still remain controversial. Objective: The aim of this report was to evaluate the effects of atorvastatin therapy on the insulin resistance in the treatment of PCOS compared to that of placebo, in order to confer a reference for clinical practice. Methods: Randomized controlled trials (RCTs) of atorvastatin for PCOS published up to August, 2020 were searched. Standardized mean difference (SMD) and 95% confidence interval (CI) were calculated, and heterogeneity was measured by the I 2 test. Sensitivity analysis was also carried out. The outcomes of interest were as follows: fasting glucose concentration, fasting insulin level, homeostasis model assessment of insulin resistance (HOMA-IR) or body mass index (BMI) value. Results: Nine RCTs with 406 participants were included. The difference of fasting glucose concentration in PCOS patients between atorvastatin group and placebo group was not statistically significant (8 trials; SMD −0.06, 95% CI −0.31 to 0.20, P = .66). PCOS patients in atorvastatin group had lower fasting insulin level than those in placebo group (7 trials; SMD −1.84, 95% CI −3.06 to −0.62, P < .003). The homeostasis model assessment of insulin resistance (HOMA-IR) value showed significant decrease in the atorvastatin therapy compared to placebo (6 trials; SMD −4.12, 95% CI −6.00 to −2.23, P < .0001). In contrast to placebo, atorvastatin therapy did not decrease the BMI value significantly in PCOS patients (7 trials; SMD 0.12, 95% CI −0.07 to 0.31, P = .22). Conclusions: Atorvastatin therapy can reduce insulin resistance in the treatment of patients with PCOS. In addition, further large-sample, multi-center RCTs are needed to identify these findings.

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“…For example, ginger has a significant effect on reducing circulating C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF- α ) levels, which are systemic inflammatory markers associated with an increased risk of cardiovascular disease [ 20 ]. Curcumin may ameliorate hyperandrogenemia and hyperglycemia associated with polycystic ovary syndrome [ 21 ]. Moreover, recent studies have found that a variety of TCM and their active components can delay aging and prevent age-related diseases [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review of Antiaging Effects of 23 Traditional Chinese Medicines

Wang

Zuo

Ouyang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Aging is an inevitable stage of body development. At the same time, aging is a major cause of cancer, cardiovascular disease, and neurodegenerative diseases. Chinese herbal medicine is a natural substance that can effectively delay aging and is expected to be developed as antiaging drugs in the future. Aim of the review. This paper reviews the antiaging effects of 23 traditional Chinese herbal medicines or their active components. Materials and methods. We reviewed the literature published in the last five years on Chinese herbal medicines or their active ingredients and their antiaging role obtained through the following databases: PubMed, EMBASE, Scopus, and Web of Science. Results. A total of 2485 papers were found, and 212 papers were screened after removing the duplicates and reading the titles. Twenty-three studies met the requirements of this review and were included. Among these studies, 13 articles used Caenorhabditis elegans as the animal model, and 10 articles used other animal models or cell lines. Conclusion. Chinese herbal medicines or their active components play an antiaging role by regulating genes related to aging through a variety of signaling pathways. Chinese herbal medicines are expected to be developed as antiaging drugs or used in the medical cosmetology industry.

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Effects of curcumin supplementation on blood glucose, insulin resistance and androgens in patients with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial

Cited by 61 publications

References 39 publications

Effects of Curcumin on Glycemic Control and Lipid Profile in Polycystic Ovary Syndrome: Systematic Review with Meta-Analysis and Trial Sequential Analysis

Effects of Curcumin on Glycemic Control and Lipid Profile in Polycystic Ovary Syndrome: Systematic Review with Meta-Analysis and Trial Sequential Analysis

Effects of atorvastatin on the insulin resistance in women of polycystic ovary syndrome

A Systematic Review of Antiaging Effects of 23 Traditional Chinese Medicines

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