Effects of curcumin on mitochondria in neurodegenerative diseases

Bagheri, Hossein; Ghasemi, Faezeh; Barreto, George E.; Rafiee, Rouhullah; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

doi:10.1002/biof.1566

Cited by 134 publications

(55 citation statements)

References 144 publications

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“…As pio, curcumin induces cell differentiation and protection from TNF-γ damage through activation of the PPAR-γ pathway in OPs [ 38 ]. On the other hand, curcumin induces phase II enzymes and protects from oxidative and mitochondrial stress by activating NRF2 in different cell types [ 57 , 58 ]. In this study, we demonstrate that, in OPs, the effect of curcumin on mMP is similar to the DMF effect, suggesting an electrophile-type effect.…”

Section: Discussionmentioning

confidence: 99%

NRF2 and PPAR-γ Pathways in Oligodendrocyte Progenitors: Focus on ROS Protection, Mitochondrial Biogenesis and Promotion of Cell Differentiation

Nuccio

Bernardo

Troiano

et al. 2020

IJMS

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An adequate protection from oxidative and inflammatory reactions, together with the promotion of oligodendrocyte progenitor (OP) differentiation, is needed to recover from myelin damage in demyelinating diseases. Mitochondria are targets of inflammatory and oxidative insults and are essential in oligodendrocyte differentiation. It is known that nuclear factor-erythroid 2-related factor/antioxidant responsive element (NRF2/ARE) and peroxisome proliferator-activated receptor gamma/PPAR-γ response element (PPAR-γ/PPRE) pathways control inflammation and overcome mitochondrial impairment. In this study, we analyzed the effects of activators of these pathways on mitochondrial features, protection from inflammatory/mitochondrial insults and cell differentiation in OP cultures, to depict the specificities and similarities of their actions. We used dimethyl-fumarate (DMF) and pioglitazone (pio) as agents activating NRF2 and PPAR-γ, respectively, and two synthetic hybrids acting differently on the NRF2/ARE pathway. Only DMF and compound 1 caused early effects on the mitochondria. Both DMF and pio induced mitochondrial biogenesis but different antioxidant repertoires. Moreover, pio induced OP differentiation more efficiently than DMF. Finally, DMF, pio and compound 1 protected from tumor necrosis factor-alpha (TNF-α) insult, with pio showing faster kinetics of action and compound 1 a higher activity than DMF. In conclusion, NRF2 and PPAR-γ by inducing partially overlapping pathways accomplish complementary functions aimed at the preservation of mitochondrial function, the defense against oxidative stress and the promotion of OP differentiation.

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Section: Discussionmentioning

confidence: 99%

NRF2 and PPAR-γ Pathways in Oligodendrocyte Progenitors: Focus on ROS Protection, Mitochondrial Biogenesis and Promotion of Cell Differentiation

Nuccio

Bernardo

Troiano

et al. 2020

IJMS

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“…107 Encouragingly, it has been reported that curcumin could protect mitochondria from oxidative damage through reducing the intracellular generation of ROS and synchronously alleviating the apoptosis of cortical neurons in rats. 108 Besides, curcumin can also ameliorate the aflatoxin B-induced apoptosis through the mitochondrial pathway in liver cells. 109 Furthermore, curcumin can not only mediate neuroprotection against mitochondrial complex I and II inhibitors by activating the nuclear factor erythroid 2-related factor 2 (Nrf2), but also mitigate the mitochondrial dysfunction by suppressing the ROS burst and the enhancing mitochondrial antioxidant gene expression.…”

Section: Mitochondrial Function-related Antidepressant Mechanismsmentioning

confidence: 99%

Curcumin in antidepressant treatments: An overview of potential mechanisms, pre‐clinical/clinical trials and ongoing challenges

Zhang

2020

Basic Clin Pharma Tox

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Depression is one of the most common but serious psychiatric disorders affecting millions of people globally, which has become increasingly prevalent during the past few decades. To alleviate this challenging health and social burden, various therapeutic strategies have been developed to achieve efficient treatments for depression. In particular, plenty of chemical ingredients of natural origin have been investigated as new direct antidepressants or served as adjuvants to improve the current treatment outcomes of existing antidepressant drugs. Among them, curcumin, a natural compound derived from the herb Curcuma longa, exhibits a wide range of pharmacological properties and has been considered a potent antidepressant drug with diverse mechanisms including monoaminergic imbalances (associated with serotonin, dopamine, noradrenaline and glutamate), effect on neurotransmitters, neuroprogression, the hypothalamic‐pituitary‐adrenal (HPA) axis disturbances, dysregulated inflammation and immune pathways, oxidative and nitrosative stress, and mitochondrial disturbances. In this review, multiple potential mechanisms of curcumin for treating depression demonstrated in either animal or human studies are summarized. To better understand the significant role of curcumin, specific emphasis will be placed on the aetiopathogenesis of depression. Finally, current pre‐clinical/clinical trials and ongoing challenges of curcumin used for antidepressant treatments will be discussed and their future outlooks will be briefly presented.

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“…Curcumin, a curcuminoid [ 1 ], is a bioactive component representing 1.5–3 wt.% [ 2 ] of the rhizome of turmeric ( Curcuma longa ) [ 3 ], also known as diferuloylmethane. This yellow pigmented powder can be obtained by grinding the rhizome of turmeric [ 4 ], owing the color to the curcumin present [ 1 , 5 ]. It has been used over the centuries for cooking, especially in Asia, as well as for treatment due to its curing properties in diseases, such as dysentery, chest congestion, and pain.…”

Section: Introductionmentioning

confidence: 99%

“…Over the past half a century, curcumin has received growing interest in biological [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ], pharmacological [ 15 , 16 , 17 , 18 , 19 ], and nutraceutical research [ 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. Interestingly, it was in 1949 that its antibacterial properties were discovered [ 1 ]. Since then, many studies have proved that curcumin also possesses other potential beneficial properties, such as anti-inflammatory [ 27 , 28 ], antiproliferative [ 29 , 30 ], antimetastatic [ 31 , 32 ], anti-angiogenic [ 29 , 33 ], antidiabetic [ 34 , 35 , 36 ], hepatoprotective [ 37 , 38 , 39 ], anti-atherosclerotic [ 40 , 41 ], antithrombotic [ 42 ], wound healing [ 43 ], anti-cancer [ 44 ], anti-arthritic [ 45 ], neuroprotective [ 46 , 47 ], analgesic [ 45 ], immunomodulatory [ 48 , 49 , 50 , 51 ], and pulmonoprotective […”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, it was in 1949 that its antibacterial properties were discovered [ 1 ]. Since then, many studies have proved that curcumin also possesses other potential beneficial properties, such as anti-inflammatory [ 27 , 28 ], antiproliferative [ 29 , 30 ], antimetastatic [ 31 , 32 ], anti-angiogenic [ 29 , 33 ], antidiabetic [ 34 , 35 , 36 ], hepatoprotective [ 37 , 38 , 39 ], anti-atherosclerotic [ 40 , 41 ], antithrombotic [ 42 ], wound healing [ 43 ], anti-cancer [ 44 ], anti-arthritic [ 45 ], neuroprotective [ 46 , 47 ], analgesic [ 45 ], immunomodulatory [ 48 , 49 , 50 , 51 ], and pulmonoprotective [ 52 , 53 ] properties, among many other effects [ 1 , 34 , 54 , 55 ], summarized in Figure 1 .…”

Section: Introductionmentioning

confidence: 99%

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Properties, Extraction Methods, and Delivery Systems for Curcumin as a Natural Source of Beneficial Health Effects

et al. 2020

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This review discusses the impact of curcumin—an aromatic phytoextract from the turmeric (Curcuma longa) rhizome—as an effective therapeutic agent. Despite all of the beneficial health properties ensured by curcumin application, its pharmacological efficacy is compromised in vivo due to poor aqueous solubility, high metabolism, and rapid excretion that may result in poor systemic bioavailability. To overcome these problems, novel nanosystems have been proposed to enhance its bioavailability and bioactivity by reducing the particle size, the modification of surfaces, and the encapsulation efficiency of curcumin with different nanocarriers. The solutions based on nanotechnology can improve the perspective for medical patients with serious illnesses. In this review, we discuss commonly used curcumin-loaded bio-based nanoparticles that should be implemented for overcoming the innate constraints of this natural ingredient. Furthermore, the associated challenges regarding the potential applications in combination therapies are discussed as well.

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Effects of curcumin on mitochondria in neurodegenerative diseases

Abstract: This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

Cited by 134 publications

References 144 publications

NRF2 and PPAR-γ Pathways in Oligodendrocyte Progenitors: Focus on ROS Protection, Mitochondrial Biogenesis and Promotion of Cell Differentiation

NRF2 and PPAR-γ Pathways in Oligodendrocyte Progenitors: Focus on ROS Protection, Mitochondrial Biogenesis and Promotion of Cell Differentiation

Curcumin in antidepressant treatments: An overview of potential mechanisms, pre‐clinical/clinical trials and ongoing challenges

Properties, Extraction Methods, and Delivery Systems for Curcumin as a Natural Source of Beneficial Health Effects

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