Effects of curcumin on antioxidative activities and cytokine production in Jian carp (Cyprinus carpio var. Jian) with CCl4-induced liver damage

Cao, Liping; Ding, Weidong; Du, Jingliang; Jia, Rui; Liu, Ying-Juan; Zhao, Caiyuan; Shen, Yu-Jin; Yin, Guojun

doi:10.1016/j.fsi.2014.12.025

Cited by 70 publications

(45 citation statements)

References 33 publications

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“…Our results are in agreement with those of few other studies that revealed the stimulatory effects of turmeric on lipase activity, digestive enzyme activity and acid and alkaline protease activity, which all enhance the yellow pigmentation and growth rate of fish (Eumkeb et al, 2012;Kang et al, 2011). Crude protein is known to be significantly augmented while ether content decreases in fish response to turmeric supplementation (Cao et al, 2015).…”

Section: Discussionsupporting

confidence: 93%

“…Increased growth seen at day 40 and day 60 indicated that the fish were acclimatized to the curcumin diet. Although a number of studies have reported beneficial effects of curcumin on growth rates, none have reported specific need for initial acclimatization of curcumin supplemented feed (Behera et al, 2010;Cao et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Natural plant extracts could be one such alternative to enhance non-specific innate immunity and resistance to diseases caused by fish pathogens such as Aeromonas hydrophila. Curcumin is an orange-yellow, hydrophobic and polyphenolic compound of turmeric (Curcuma longa) that has been shown to be an anti-inflammatory and immunomodulatory agent in fish species (Cao et al, 2015;Kang et al, 1999). However, studies depicting actual enhancement of disease resistance are lacking.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Curcumin as an Immunostimulatory Dietary Supplement for Channel Catfish

Hafiz¹,

Srivastava²,

Newton³

et al. 2017

American Journal of Animal and Veterinary Sciences

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Natural agents such as curcumin may have the potential to enhance disease resistance in aquaculture. In this study, 30 catfish (Ictalurus punctatus), 2 years of age, were allotted to one of 3 treatment groups (n = 10) to receive diets supplemented with 0.0, 0.5, or 1.0% curcumin. Body weights and lengths of fish were taken at 0, 20, 40 and 60 days after starting the fish on experimental diets. At 60 days, blood samples were collected from 9 fish of each group and then were challenged with Aeromonas hydrophila (0.1 mL of 9×10 6 CFU/mL) intra-peritoneally. Morbidity and mortality was observed daily for 7 days following challenge. Serum separated from blood samples was analyzed for the cytokines, interleukin-4 (IL-4) and interleukin-12 (IL-12). Results indicated significantly higher body weights and lengths but lower levels of both IL-4 and IL-12 with curcumin at 0.5 and 1.0% than the control group. At 24 h following challenge with A. hydrophila, mortality was100 (9/9), 33 (3/9) and 22% (2/9) in the fish supplemented with 0.0, 0.5 and 1.0% curcumin, respectively. At 48 h following challenge, two more fish in the 0.5% group died but the fish remaining in 1.0% group survived even after 7 days. Results of this study suggest that curcumin has the potential to enhance performance of catfish and increase their disease resistance which may help in reducing use of antimicrobials in fish farming.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efficacy of Curcumin as an Immunostimulatory Dietary Supplement for Channel Catfish

Hafiz¹,

Srivastava²,

Newton³

et al. 2017

American Journal of Animal and Veterinary Sciences

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“…Furthermore, CUR has been reported to inhibit the host NFκB signalling pathway, which is activated during several parasite infections and interferes in inflammation and oxidative stress (Haddad, Sauvain & Deharo ; Cao et al . ). The safety profile of CUR has so far been found to be excellent (Clarke & Mullin ; He et al .…”

Section: Introductionmentioning

confidence: 97%

“…It also inhibits the activity of enzymes involved in parasite metabolism, such as S-acyl-homocysteine hydrolase (SAHH), which regulates methylation reactions, and it has been reported to be an appropriate pharmacological target in different parasitic diseases (Tanaka et al 2004;Walker et al 2012). Furthermore, CUR has been reported to inhibit the host NFjB signalling pathway, which is activated during several parasite infections and interferes in inflammation and oxidative stress (Haddad, Sauvain & Deharo 2011;Cao et al 2015). The safety profile of CUR has so far been found to be excellent (Clarke & Mullin 2008;He et al 2015), and the compound has shown positive effects on growth of fish in aquaculture (Manju, Akbarsha & Oommen 2012;Manju et al 2013;Mahfouz 2015).…”

Section: Introductionmentioning

confidence: 99%

Combined antiparasitic and anti‐inflammatory effects of the natural polyphenol curcumin on turbot scuticociliatosis

Mallo

Defelipe

Folgueira

et al. 2016

Journal of Fish Diseases

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The histiophagous scuticociliate Philasterides dicentrarchi is the aetiological agent of scuticociliatosis, a parasitic disease of farmed turbot. Curcumin, a polyphenol from Curcuma longa (turmeric), is known to have antioxidant and anti-inflammatory properties. We investigated the in vitro effects of curcumin on the growth of P. dicentrarchi and on the production of pro-inflammatory cytokines in turbot leucocytes activated by parasite cysteine proteases. At 100 μm, curcumin had a cytotoxic effect and completely inhibited the growth of the parasite. At 50 μm, curcumin inhibited the protease activity of the parasite and expression of genes encoding two virulence-associated proteases: leishmanolysin-like peptidase and cathepsin L-like. At concentrations between 25 and 50 μm, curcumin inhibited the expression of S-adenosyl-L-homocysteine hydrolase, an enzyme involved in the biosynthesis of the amino acids methionine and cysteine. At 100 μm, curcumin inhibited the expression of the cytokines tumour necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) produced in turbot leucocytes activated by parasite proteases. Results show that curcumin has a dual effect on scuticociliatosis: an antiparasitic effect on the catabolism and anabolism of ciliate proteins, and an anti-inflammatory effect that inhibits the production of proinflammatory cytokines in the host. The present findings suggest the potential usefulness of this polyphenol in treating scuticociliatosis.

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Perspectives of Nanotechnology in Aquaculture: Fish Nutrition, Disease, and Water Treatment

Gabriel¹,

Habte‐Tsion²,

Haulofu³

2022

Nanotechnology in the Life Sciences

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Effects of curcumin on antioxidative activities and cytokine production in Jian carp (Cyprinus carpio var. Jian) with CCl4-induced liver damage

Cited by 70 publications

References 33 publications

Efficacy of Curcumin as an Immunostimulatory Dietary Supplement for Channel Catfish

Efficacy of Curcumin as an Immunostimulatory Dietary Supplement for Channel Catfish

Combined antiparasitic and anti‐inflammatory effects of the natural polyphenol curcumin on turbot scuticociliatosis

Perspectives of Nanotechnology in Aquaculture: Fish Nutrition, Disease, and Water Treatment

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