ATURAL resources are considered the main sources of our life, which include water, energy and food. On the other hand, exponential global human population has place increased stress on such resources and therefore all nations ae enforced to double the productivity of fresh water, clean energy, and healthy food by more than 50-70% to meet their actual needs. These increases are not so easy to be achieved, particularly under climate change. Several approaches are proposed to mitigate the climate change under the Water-Energy-Food (WEF) nexus especially via applying nanomaterials (NMs). This review article describes the evaluation and implementation of applying NMs under climate change in search of suitable proposals to remedy these problems by analyzing the available literature of WEF nexus. The evidences that support the relationship between NMs with WEF nexus and climate change seem weak and/or inconclusive. What is not yet understood is the relative importance of the various factors that might support the global efforts to mitigate climate change and it environmental issues. Many of the available literatures on WEF nexus deal with the question of what are the direct and indirect impacts of climate change on WEF resources, but what remains still unclear is whether applied NMs is a suitable solution or not? The single most striking observation to emerge from the data comparison was several previous studies confirmed the importance of NMs for the environmental problems under certain doses. So far, more studies are needed to explore the relationship between WEF nexus and climate change after applying NMs. In view of all that has been mentioned so far, one may suppose that applied NMs are crucial for conserving WEF resources, but the nanotoxicity is a serious threat should be considered in the further studies.