Effects of cumin (Cuminum cyminum L.) essential oil and chronic heat stress on growth performance, carcass characteristics, serum biochemistry, antioxidant enzyme activity, and intestinal microbiology in broiler chickens

Cumin (Cuminum cyminum L.) seeds accelerates wound healing in rats: Possible molecular mechanisms

“…Accordingly, numerous investigators reported the antioxidant efficacy of CCS extracts in separate trials (in vivo and in vitro), which were linked with their phytochemical profiles (terpenes, phenolic, and flavonoids). 19,51,52 The elevation of free radicles and increased rate of oxidative stress can generate a process called lipid peroxidation, which is a series of lipid degradation processes that can have a destructive effect on the cell organelles and can increase membrane permeability, altering collagen metabolism, proliferation of fibroblast, and easy access of keratinocyte. The lipid peroxidation in damaged skin tissues near can have inhibitory action on the production of endothelial growth factor (vascularization), causing further delay in wound contraction.…”

“…Accordingly, studies have shown that ingestion of CCS extracts caused a significant reduction of lipid peroxidation (lower MDA levels) in animal models had chemical-mediated oxidative stress. [52][53][54] A healing tissue in repaired wounds produces increased collagen protein, as one of the essentials required for tissue regeneration and for the final two stages of wound repair. 4-Hydroxyproline (HXP) is the main amino acid of collagen that comprises nearly 13.5% of its amino acid content which allows collagen twisting helix to maintain its integrity and structural stability.…”

“…The methanolic extracts of CCS showed significant radical quenching actions represented by lower SOD and CAT levels in rat's tissue homogenate, thereby reducing the rate of oxidative damage which can have a devastating effect on wounded tissues and the wound process of wound curing. Accordingly, numerous investigators reported the antioxidant efficacy of CCS extracts in separate trials (in vivo and in vitro), which were linked with their phytochemical profiles (terpenes, phenolic, and flavonoids) 19,51,52 …”

“…While rats receiving intrasite gel or methanolic extracts of CCS had significantly reduced values of MDA, denoting antioxidant potentials of these agents against oxidative damages that would otherwise delay the wound healing process. Accordingly, studies have shown that ingestion of CCS extracts caused a significant reduction of lipid peroxidation (lower MDA levels) in animal models had chemical‐mediated oxidative stress 52–54 …”

Effect of Bacteriocins on the Intestinal Microbiota

“…The significance of LAB metabolites lies in their ability to uphold the balance and stability of the intestinal microbiota, owing to these properties. 16 - 21 …”