Effects of Cultured Milk Products by Lactobacillus and Bifidobacterium Species on the Secretion of Bile Acids in Hepatocytes and in Rats.

Imaizumi, Kazunori; Hirata, Keizaburo; Zommara, Mohsen; Sugano, Michihiro; Suzuki, Yutaka

doi:10.3177/jnsv.38.343

Cited by 14 publications

(9 citation statements)

References 12 publications

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“…Nagata (1982) also found that soy products could increase the bile acid content in rat feces and affects the metabolism of liver cholesterol since bile acid synthesis requires cholesterol [64,65]. These results may be explained by the stimulation of bile acid secretion and the activity of 7α-hydroxylase cholesterol synthesis induced by LAB and isoflavones [66][67][68].…”

Section: Discussionmentioning

confidence: 99%

Effects of Tempeh Fermentation with Lactobacillus Plantarum and Rhizopus Oligosporus on Streptozotocin-Induced Type II Diabetes Mellitus in Rats

Huang

Chu

et al. 2018

Preprint

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contributed equally to this work. AbstractThe increased consumption of high fat-containing foods has been linked to the prevalence of obesity and abnormal metabolic syndromes. Rhizopus oligosporus, a fungus in the family Mucoraceae, is widely used as a starter for homemade tempeh.Although R. oligosporus can prevent the growth of other microorganisms, it grows well with lactic acid bacteria (LAB). Lactobacillus plantarum can produce β-glucosidase, which catalyzes the hydrolysis of glucoside isoflavones into aglycones (with greater bioavailability). Therefore, the development of a soybean-based functional food by the co-inoculation of R. oligosporus and L. plantarum is a promising approach to increase the bioactivity of tempeh. In this study, the ameliorative effect of L. plantarum in soy tempeh on abnormal carbohydrate metabolism in high-fat diet (HFD)-induced hyperglycemic rats was evaluated. The co-incubation of L. plantarum with R.oligosporus during soy tempeh fermentation reduced the homeostatic model assessment of insulin resistance, HbA1c, serum glucose, total cholesterol, triglyceride, Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 31 free fatty acid, insulin, and low-density lipoprotein contents and significantly increased the high-density lipoprotein content in HFD rats. It also increased the LAB counts as well as the bile acid, cholesterol, triglyceride, and short-chain fatty acid contents in the feces of HFD rats. Our results suggested that the modulation of serum glucose and lipid levels by LAB occurs via alterations in the internal microbiota, leading to the inhibition of cholesterol synthesis and promotion of lipolysis. Tempeh, produced with both L. plantarum and R. oligosporus, may be a beneficial dietary supplement for individuals with abnormal carbohydrate metabolism.

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Section: Discussionmentioning

confidence: 99%

Effects of Tempeh Fermentation with Lactobacillus Plantarum and Rhizopus Oligosporus on Streptozotocin-Induced Type II Diabetes Mellitus in Rats

Huang

Chu

et al. 2018

Preprint

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“…Moreover, the production of gas (H 2 , CH 4 and CO 2 ) may distend the intestinal wall and accelerate the peristaltic activity. Since Imaizumi et al (29) described an increased secretion of bile salts in feces of rats following bi dobacteria ingestion, it could be possible that bile salts irritate the colon and increase the motility. However, other mechanisms such as hormonal delivery (CCK) might be involved (30).…”

Section: Discussionmentioning

confidence: 99%

A Fermented Milk with a Bifidobacterium Probiotic Strain DN-173 010 Shortened Oro-Fecal Gut Transit Time in Elderly

Meance¹,

Cayuela

Turchet³

et al. 2001

Microbial Ecology in Health and Disease

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Fermented milks have been proposed to modulate gut transit time. Reduction of long transit times may be of importance in decreasing susceptibility to some large bowel diseases. Objecti×e: to assess the effect on gut transit time in free-living elderly of a regular consumption of the milk fermented by the probiotic strain Bi dobacterium animalis DN-173 010 (10 8 CFU g) and lactic acid cultures (10 8 CFU g) (BM). Design: a randomized study was performed with 4 groups: 50 subjects with a stable transit time under 40 h (UTT: 24.6 h, SD ¾1.7) and 50 subjects with a stable transit time over or equal to 40 h (OTT: 64.1 h, SD ¾13.3) were included. Subjects from each transit group were randomly assigned to eat during 2 weeks, either 2 or 3 servings per day of BM. The oro-fecal transit time was measured before and after BM consumption using a colored marker technique. Results: in the 4 groups, comparing values before and after BM consumption, the transit time reductions were statistically signi cant, being around 10% in UTT and around 40% in OTT (pB 0.001). In UTT as well as in OTT, 3BM were more active than 2BM (p B0.05). Conclusions : in elderly, the long gut transit times have been shortened by a 2-week regular consumption of the milk fermented with the strain Bi dobacterium animalis DN-173 010 and lactic cultures. This speci c fermented milk can be considered as a functional food.

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“…Imaizumi, Hirata, Zommara, Sugano, and Suzuki (1992) reported that Bifidobacterium spp. enhance both the secretion of bile acids and the activity of cholesterol 7-a-hydroxylase, a rate-limiting enzyme in the synthesis of bile acids.…”

Section: Faecal Bile Acid Excretionmentioning

confidence: 98%

Hypocholesterolaemic effect of yoghurt containing Bifidobacterium pseudocatenulatum G4 or Bifidobacterium longum BB536

et al. 2012

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The effect of a yoghurt supplement containing Bifidobacterium pseudocatenulatum G4 or Bifidobacterium longum BB536 on plasma lipids, lipid peroxidation and the faecal excretion of bile acids was examined in rats fed a cholesterol-enriched diet. After 8 weeks, the rats in the positive control (PC) group who were fed the cholesterol-enriched diet showed significant increases in plasma total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, and malondialdehyde (MDA). However, groups fed a cholesterol-enriched diet supplemented with yoghurt containing B. pseudocatenulatum G4 or B. longum BB536 had significantly lower plasma TC, LDL-C, very-low-density lipoprotein (VLDL) cholesterol, and MDA than had the PC group after 8 weeks of treatment. In addition, faecal excretion of bile acids was markedly increased in the rats fed the yoghurt containing B. pseudocatenulatum G4 or B. longum BB536 as compared to the PC and NC groups.

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Effects of Cultured Milk Products by Lactobacillus and Bifidobacterium Species on the Secretion of Bile Acids in Hepatocytes and in Rats.

Cited by 14 publications

References 12 publications

Effects of Tempeh Fermentation with Lactobacillus Plantarum and Rhizopus Oligosporus on Streptozotocin-Induced Type II Diabetes Mellitus in Rats

Effects of Tempeh Fermentation with Lactobacillus Plantarum and Rhizopus Oligosporus on Streptozotocin-Induced Type II Diabetes Mellitus in Rats

A Fermented Milk with a Bifidobacterium Probiotic Strain DN-173 010 Shortened Oro-Fecal Gut Transit Time in Elderly

Hypocholesterolaemic effect of yoghurt containing Bifidobacterium pseudocatenulatum G4 or Bifidobacterium longum BB536

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