This work mainly focuses on the mechanical and anti‐infection deficiencies of zinc alloy‐based bone implant materials. Microstructural analysis, tensile testing, electrochemical investigation, immersion experiments and antibacterial testing were used to investigate the effects of Cu content on the mechanical properties, corrosion resistance, and antibacterial properties of the Zn‐1Mg‐xCu (x =0, 0.5, 1, 1.5 and 2wt.%) alloys. The results showed that the addition of Cu to Zn‐1Mg alloy produced a high‐strength and high‐hardness intermediate phase of CuZn5, which significantly increased the tensile strength from 115.2 MPa to 210.6 MPa, elongation from 1.9% to 5.72%, the diameter of the inhibition zone increased from 3.3 mm to 5.1 mm, and the cytotoxicity level of all alloys improved, reaching up to grade 1. Consequently, these findings suggest that the Zn‐1Mg‐2Cu alloy possesses the best mechanical properties, most uniform degradation rate, impressive antibacterial properties, and an excellent biocompatibility. Therefore, the Zn‐1Mg‐2Cu alloy is considered a most preferred material candidate in the field of biodegradable Zn alloys.This article is protected by copyright. All rights reserved.