Effects of CS-US interval on conditioning of drug response, with assessment of speed of conditioning

Pickens, Roy W.; Crowder, William F.

doi:10.1007/bf00401511

Cited by 87 publications

(49 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar results of conditioning drug effects have been stated by different groups of researchers (14)(15)(16)(17)(18)(19). Hayashi et al (14) also reported that the enhancement of effect on motor activity of mice was elicited by a small dose (0.25 mg/ kg) of d-amphetamine associated with the presentation of a flickering light as a con ditioned stimulus.…”

Section: Discussionsupporting

confidence: 79%

Enhancement of motor-accelerating effect induced by repeated administration of methamphetamine in mice: Involvement of environmental factors.

Alam

1981

Jpn.J.Pharmacol

View full text Add to dashboard Cite

Abstract-Adult male mice were given 2.0 mg/kg of methamphetamine hydrochloride (MAM) for 6 times at 3-4 day intervals.The acute effects of MAM on locomotor activity of each mouse were investigated for 180 min after each administration.The motor-accelerating effect of MAM was progressively enhanced in parallel to the number of administrations. However, the enhancement of effect was not observed after repeated administration of MAM, when the mice were placed individually in narrow jars, which thereby perfectly inhibited ambulation during 180 min following each administration.The other mice were trained under the discriminated shuttle-type avoidance schedule (intertrial interval= 25 sec, CS presen tation= 5 sec and 1 session= 1 hr). A slight influence of training on locomotor activity was detected after 2.0 mg/kg of MAM in the activity cage. A marked enhancement of the motor-accelerating effect was detected in the avoidance-trained mice, when 2.0 mg/kg of MAM was given for 5 times at 3-4 day intervals in the avoidance situation.These results suggest that the conditioned drug effect in association with environmental factors plays an important role in the production of enhancement.

show abstract

Section: Discussionsupporting

confidence: 79%

Enhancement of motor-accelerating effect induced by repeated administration of methamphetamine in mice: Involvement of environmental factors.

Alam

1981

Jpn.J.Pharmacol

View full text Add to dashboard Cite

show abstract

“…As pointed out by Schiff (1982), since the original observation of Pavlov (1927) that some symptoms seen with an acute morphine injection could be elicited by preinjection procedure alone, numerous investigators demonstrated the classical conditioning of morphine responses (see Lynch et al 1976). In this respect, hyperactivity and stereotyped behaviors induced by dopamine agonists such as apomorphine, amphetamine and L-DOPA have also been conditioned in rodents (Pickens and Crowder 1967;Tilson and Rech 1973;Schiff et al 1980;Schiff 1982;Hiroi and White 1989;Carey 1992). However, in all of these studies the conditioned stimulus was an injection procedure with signals such as tone and/or specific environments.…”

Section: Discussionmentioning

confidence: 99%

Conditioning to Injection Procedures and Repeated Testing Increase SCH 23390-Induced Catalepsy in Mice

Chinen

Frussa‐Filho

1999

Neuropsychopharmacology

View full text Add to dashboard Cite

The cataleptic behavior induced by the dopamine D 1 antagonist SCH 23390 (SCH) has proven to be a useful assay for investigating the sensitivity of D 1 -like dopamine receptor-mediated effects during chronic drug administration. A fundamental flaw in most of these studies may be the involvement of the "repeated measures effect," a behavioral phenomenon well demonstrated for neurolepticinduced catalepsy but not yet investigated for dopamineThe ability of chronic neuroleptic treatment to produce increasing or decreasing degrees of both Parkinsonism in humans (see Hansen and Hoffman 1997) and catalepsy in laboratory animals (Barnes et al. 1990) over time remains controversial. Specifically, concerning the evolution of catalepsy during chronic haloperidol treatment, tolerance (Asper et al. 1973;Ezrin-Waters and Seeman 1977;Campbell and Baldessarini 1981), sensitization (Antelman et al. 1986;Kinon and Kane 1989;Barnes et al. 1990), or no effects (György et al. 1969;Moller Nielsen et al. 1974;Frussa-Filho et al. 1992) have been reported. Although the patterns of change in catalepsy responses to chronic neuroleptic treatment are influenced by multiple determinants (Barnes et al. 1990), two specific biological mechanisms seem to be of particular importance in determining the development of tolerance or sensitization: dopamine receptor supersensitivity (Ezrin-Waters and Seeman 1977;Hoffman and Beninger 1988) and a learning process due to repeated testing in the catalepsy apparatus (Iwata et al. 1989;Ferré et al. 1990), respectively. In regards to the learning process, both repeated measures in a single session after acute haloperidol administration (Stanley and Glick 1976;Hillegaart et al. 1987 Received October 12, 1998; revised April 30, 1999; accepted May 17, 1999. N EUROPSYCHOPHARMACOLOGY 1999 -VOL . 21 , NO . 5 Conditioning and SCH 23390-Induced Catalepsy 671 et al. 1990) have been reported to markedly enhance the cataleptic behavior presented by rodents.For many years, dopamine D 2 -like receptors were implicated as the only site mediating the cataleptic behavior of neuroleptics (Seeman 1980). However, in 1984, Christensen et al. (1984 first reported the cataleptogenic properties of SCH 23390, a selective antagonist of D 1 -like dopamine receptors (Hyttel 1983). Thus, besides providing a functional correlate of dopamine D 1 receptor antagonism (Mizuki et al. 1996), SCH 23390-induced catalepsy has proven to be a useful assay for investigating the functional interactions between D 1 -and D 2 -like dopamine receptors (see Klemm 1993). Catalepsy has also been used to investigate the sensitivity of D 1 -like dopamine receptor-mediated effects during chronic drug administration. In two landmark investigations, Hess et al. (1986Hess et al. ( , 1988 reported that although chronic treatment of rats with SCH 23390 resulted in an increase in D 1 -like striatal dopamine receptors as well as in spontaneous locomotion and D 1 -like and D 2 -like dopamine agonist-induced stereotypy, no tolerance to the cataleptic effect ...

show abstract

“…The experiment determined whether the set of behavioral CRs elicited by an amphetaminepaired contextual test chamber was similar or dissimilar to the set of CRs elicited by the lithium-paired contextual test chamber in Experiments 1 and 2. That is, was there a common nonspecific US across drugs associated with the CS, as suggested in the literature of conditioned flavor aversion learning (e.g., Bravemen, 1975), or was the US associated with the CS specific to each drug, as suggested in the conditioned drug effects literature (e.g., Pickens & Crowder, 1967)? The dose of amphetamine used (3.0 mg/kg) was selected because Parker (1982) had reported that this dose produces a flavor aversion equivalent to that produced by the highest dose of lithium employed in Experiment 1 (3.0 mEq/kg).…”

Section: Methodsmentioning

confidence: 99%

“…Since Pavlov's original investigations, conditioned drug effects have been shown with a variety of pharmacological agents. For instance, Pickens and Crowder (1967) demonstrated that the increase in activity produced by amphetamine could be conditioned to an environmental chamber when the chamber was paired with amphetamine on each of six trials.…”

mentioning

confidence: 99%

Behavioral CRs elicited by a lithium- or an amphetamine-paired contextual test chamber

Parker

Hills

Jensen

1984

Animal Learning & Behavior

View full text Add to dashboard Cite

The behavioral CRs elicited by a drug-paired contextual cue in rats were measured in a series of experiments. The first three experiments measured the pattern of CRs elicited by a lithiumand an amphetamine-paired CS chamber. The final experiment measured the pattern of URs elicited by lithium or amphetamine when administered in the same chamber. The suppression of grooming-related activities (body washing, face washing, and/or scratching) appeared as a nonspecific effect of both drug USs that was capable of becoming conditioned to the contextual chamber cue. A number of other behaviors differed among conditions, which provides evidence that contextual cue-drug associations are drug-specific. Of the behaviors that differed between the two US drug conditions, lithium CRs showed evidence of behavioral activation (enhanced rearing and limb flicking), but amphetamine CRs showed evidence of behavioral suppression (line crossing, rearing, and shaking). The UR patterns shared some similar and some dissimilar elements of the CR patterns elicited by the CS chamber for both lithium and amphetamine; in fact, by the activity and rearing measures, the URs and CRs were opposite in direction. The results exclusively supported neither stimulus substitution nor conditioned compensatory response accounts of Pavlovian conditioning; instead, each process appears to have accounted for different components of the overall CR pattern.

show abstract

Effects of CS-US interval on conditioning of drug response, with assessment of speed of conditioning

Cited by 87 publications

References 3 publications

Enhancement of motor-accelerating effect induced by repeated administration of methamphetamine in mice: Involvement of environmental factors.

Enhancement of motor-accelerating effect induced by repeated administration of methamphetamine in mice: Involvement of environmental factors.

Conditioning to Injection Procedures and Repeated Testing Increase SCH 23390-Induced Catalepsy in Mice

Behavioral CRs elicited by a lithium- or an amphetamine-paired contextual test chamber

Contact Info

Product

Resources

About