Effects of Crude Extract of Dry Fruits of Piper guineense on Male Fertility Parameters of Adult Sprague Dawley Rats

Memudu, Adejoke Elizabeth; Akinrinade, Ibukun; Ogundele, Olalekan Michael; Dare, B. J.

doi:10.9734/ejmp/2015/9466

Cited by 12 publications

(13 citation statements)

References 8 publications

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“…In recent years, researchers have focused on Nigella sativa commonly known as black seed and Piper guineense commonly known as Uziza whose aqueous extracts were reported to have a positive influence on the reproductive profile; Piper guineense was found to have exerted hypolipidemic effects by reducing the cholesterol induced body weight and increased the body's anti-oxidant defense system, as well asinfluencing the increase in steriodogenic pathways that mediated testosterone production [7,8].…”

Section: Hyperlipidemiamentioning

confidence: 99%

“…Thirty (30) Wistar rats (15 males and 15 females) weighing about100g were purchased fromChoba animal house, Department of Biochemistry, University of Port Harcourt. They were fed with growers mash and water ad libitum for seven (7) weeks. One week prior to start of experiment, they were held in experimental room in close observations to acclimate them with experimental room.…”

Section: Experimental Animalsmentioning

confidence: 99%

“…Administration of extract was carried out orally by the use of syringes in order to determine the actual dose. The animals received their doses seven (7) times weekly for a period of three (3) weeks. At the end of each week, the rats from each group was sacrificed through the means of cervical strangulation and blood samples were collected.…”

Section: Preparation Of Black Seed (Nigella Sativa)mentioning

confidence: 99%

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The Effect of Nigella sativa and Piper guineense Aqueous Extracts on the in Vivo Expression Profile of Lipid and Sex Hormones

Franca

Rume

2019

BJI

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Aim: The study investigated the effect of aqueous extract of Piper guineense and Nigella sativa on Testosterone, Estrogen and Follicle stimulating hormone levels in male and female rats induced by diets supplemented with high dose of sucrose and margarine for four (4) week. Materials and Methods: Thirty male and female Wistar rats of average weight (100 g) were used for the study. The rats were arranged into five groups with six rats in each of the groups. The rats had access to their normal feed but sucrose and margarine were used to induce hyperglycemia and hyperlipidemia respectively on the rats with the exception of the rats in the positive control group. The rats in the negative control were induced using the sucrose and margarine but were not treated using the aqueous extracts. The rats in the Piper guineense group were treated with 2 ml of Piper guineense aqueous leaf extract, while the rats in the Nigella sativa group were treated with 2 ml of Nigella sativa aqueous extract. The rats in the Nigella sativa and Piper guineense group were treated with 2 ml of the combined aqueous extract. Results: The results showed that the extracts had an increasing effect which was time dependent on the hormones. The highest increase was obtained on the third week of feeding when compared to the control. The testosterone levels (mlU/ml) showed for the, positive control (2.28 ± 0.08), uziza leaf (6.45 ± 0.01), black seed (2.85 ± 0.01), black seed &uziza (8.47 ± 0.08)(p<0.05). The increase for estrogen levels (mlU/ml) showed for the positive control (99 ± 0.82), uziza leaf (98 ± 1.63), black seed (100 ± 1.63), black seed & uziza (113 ± 0.82). Furthermore, the extracts also had an increasing effect on the follicle stimulating hormone levels with the highest increase obtained on the third week (p>0.05). The FSH levels (mlU/ml)) showed for the positive control (0.23 ± 0.01), uziza leaf 0.25 ± 0.01), black seed (0.54 ± 0.02), black seed & uziza (0.58 ± 0.01)(p<0.05). Histopathological findings also suggest that treatment with the aqueous extracts of P.guineense and N .sativa after inducement salvaged the testes and ovaries when compared to the induced group after the second week of administration. Although the combined mixture N.sativa and P.guineense extract was more effective. Conclusion: The results of the study indicate that the aqueous extract of a combined mixture of Nigella sativa and Piper guineense might be an effective plant in indigenous medicine, which may be used to combat infertility caused by hormonal imbalance.

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Section: Hyperlipidemiamentioning

confidence: 99%

Section: Experimental Animalsmentioning

confidence: 99%

Section: Preparation Of Black Seed (Nigella Sativa)mentioning

confidence: 99%

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The Effect of Nigella sativa and Piper guineense Aqueous Extracts on the in Vivo Expression Profile of Lipid and Sex Hormones

Franca

Rume

2019

BJI

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“…The pathophysiology of primary hyperlipidemia involve the idiopathic hyperchylomicronemia in which defect in lipid metabolism leads to hypertriglyceridemia and hyperchylomicronemia caused by a defect in lipoprotein lipase activity or the absence of the surface apoprotein CII31. In secondary hyperlipidemia, the postprandial absorption of chylomicrons from the gastrointestinal tract occurs 30-60 min after ingestion of a meal containing fat that may increase serum triglycerides for 3-10 hours [15].…”

Section: Hyperlipidemiamentioning

confidence: 99%

Effect of Black Seed (Nigella sativa) and Uziza (Piper guineense) Leaf on the Histology of the Liver of Wistar Albino Rats

Franca

Ikiriko

2019

BJI

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Aim: This study was aimed at investigating the effects of aqueous extracts of both Nigella sativa and Piper guineense on the liver enzymes; alanine amino transferase (ALT), aspartate amino transferase (AST) and alkaline phosphatase (ALP). Also the effect of Nigella sativa and Piper guineense extracts on the histology of the liver of Wistar rat was also studied. Materials and Methods: A total of twenty five Wistar rats were used for the study. The animals were grouped into five groups, each having five animals. They were induced with sucrose and margarine to cause high sugar levels and hyperlipidemia respectively except the positive control group which was fed normal feed. The groups were: the positive control group, the negative control group which were induced without treatment, the uziza leaf group which were induced and were treated with 2 ml of aqueous extract of uziza leaf, the black seed group which were induced and were treated with 2 ml of aqueous extract of black seed, and the black seed and uziza group which were induced and were treated with 2ml of aqueous extract of black seed and 2 ml of aqueous extract of uziza leaf. Results: The result showed that the extracts decreased the ALT and AST and ALP activities in the rats in a time dependent manner with highest decrease obtained on the third week of treatment with the extracts. The ALT activity (U/L) on the third week of treatment showed for the, negative control (64.48 ± 0.22), uziza leaf (28.82 ± 0.12), black seed (32.65 ± 0.02), black seed and uziza leaf (16.04 ± 0.02) (p≤0.05). The decrease in activity for AST levels (U/L) on the third week of treatment, showed for the negative control (58.00 ± 0.02), uziza leaf (11.00 ± 0.01), black seed (12.00 ± 0.02), black seed and uziza leaf (8.00 ± 0.02). Conclusion: It can be concluded that both uziza leaf and black seed have hepatoprotective effect on the liver.

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“…Some of the factors responsible for this infertility are associated or traced to hormonal secretion, erectile impotency, disorders of ejaculations, toxic effects of substances on testes and accessory sex organ. [3] Over the years, plant extracts and plant-derived medicines have made immense contributions to the overall health and well being of human beings. [4] The use of plants as medicine by people dates as far back as the beginning of civilization.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Effect of Ethanolic Leaf Extract of Piper Guineense in Aluminium Chloride Induced Reproductive Toxicity and Oxidative Stress in Male Albino Rats.

Arhoghro¹

2017

WJPPS

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Aluminium is one of the highly abundant element in the environment and the and the third most common metal in the earth crust. Piper guinense is herbal medicine used for the treatment of many diseases like infertility. This study shows the antioxidant effect of Piper guineense on infertility caused by aluminium chloride in male wistar rats. Male wistar albino rats weighing between 150-200g was randomly separated into five different groups. The first group served as negative control and received distilled water and standard feed. Group two served as positive control and received AlCl 3 (4.3mg/kg bw) and Group three received AlCl 3 (4.3mg/kg bw) and Piper guineense (100mg/kg bw) for 21 days.There was a significant (P<0.05) decrease in the activities of SOD, CAT, GPX, GST, GSH and there was a significant (P<0.05) increase in LPO from, in rats treated with AlCl 3 (4.3mg/kg bw) compared to the negative control.Also there was a significant (P<0.05) increase in the activities of SOD , CAT, GPX, GST and GSH in rat testis treated with Piper guineense (100mg/kg bw) plus AlCl 3 (4.3mg/kg bw) compared to the positive control while there was a significant (P<0.05) decrease in LPO from12.75 ± 0.521to 9.02 ± 0.439 in rat's testis treated with Piper guineense (100mg/kg bw) plus AlCl 3 (4.3mg/kg bw) compared to the positive control. There was a significant (P<0.05) increase in activities of ALT and AST, in rat serum treated with AlCl 3 (4.3mg/kg bw) compared to the negative control and there was a

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Effects of Crude Extract of Dry Fruits of Piper guineense on Male Fertility Parameters of Adult Sprague Dawley Rats

Cited by 12 publications

References 8 publications

The Effect of Nigella sativa and Piper guineense Aqueous Extracts on the in Vivo Expression Profile of Lipid and Sex Hormones

The Effect of Nigella sativa and Piper guineense Aqueous Extracts on the in Vivo Expression Profile of Lipid and Sex Hormones

Effect of Black Seed (Nigella sativa) and Uziza (Piper guineense) Leaf on the Histology of the Liver of Wistar Albino Rats

Antioxidant Effect of Ethanolic Leaf Extract of Piper Guineense in Aluminium Chloride Induced Reproductive Toxicity and Oxidative Stress in Male Albino Rats.

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