Effects of Crocin on Diabetic Maculopathy: A Placebo-Controlled Randomized Clinical Trial

Sepahi, Samaneh; Mohajeri, Seyed Ahmad; Hosseini, Seyedeh Maryam; Khodaverdi, Elham; Shoeibi, Nasser; Namdari, Maral; Tabassi, Sayyed Abolghasem Sajadi

doi:10.1016/j.ajo.2018.03.007

Cited by 88 publications

(111 citation statements)

References 34 publications

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“…and (c) studies that evaluated the effect of saffron in combination with other foods and supplements (n = 2). Fourteen articles (18 arms) representing 788 participants (Abedimanesh et al, 2017;Azimi, Ghiasvand, Feizi, Hariri, & Abbasi, 2014;Fadai et al, 2014;Gout et al, 2010;Jafarnia et al, 2017;Javandoost et al, 2017;Kermani, Kazemi, et al, 2017;Kermani, Zebarjadi, et al, 2017;Mansoori et al, 2011;Milajerdi et al, 2018;Modaghegh, Shahabian, Esmaeili, Rajbai, & Hosseinzadeh, 2008;Mohamadpour, Ayati, Parizadeh, Rajbai, & Hosseinzadeh, 2013;Nikbakht-Jam et al, 2016;Sepahi et al, 2018) met our inclusion criteria and were included in the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Characteristics of eligible studies are shown in Table 1. Most studies were conducted in Iran (Abedimanesh et al, 2017;Azimi et al, 2014;Fadai et al, 2014;Jafarnia et al, 2017;Javandoost et al, 2017;Kermani, Kazemi, et al, 2017;Kermani, Zebarjadi, et al, 2017;Mansoori et al, 2011;Milajerdi et al, 2018;Modaghegh et al, 2008;Mohamadpour et al, 2013;Nikbakht-Jam et al, 2016;Sepahi et al, 2018) and one in France (Gout et al, 2010). The sample size of the included studies ranged from 20 to 81 individuals with mean age of 43 years in intervention groups and 45 years in control groups.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The results of the quality assessment of included studies are provided in Table 2. Four arms have fair quality (Modaghegh et al, 2008;Mohamadpour et al, 2013;Nikbakht-Jam et al, 2016), one has poor quality , and 13 have good quality (Abedimanesh et al, 2017;Fadai et al, 2014;Gout et al, 2010;Jafarnia et al, 2017;Javandoost et al, 2017;Kermani, Kazemi, et al, 2017;Kermani, Zebarjadi, et al, 2017;Mansoori et al, 2011;Milajerdi et al, 2018;Sepahi et al, 2018). Most studies demonstrated adequate quality for key factors.…”

Section: Quality Assessmentmentioning

confidence: 99%

“…Sixteen studies providing a total of 619 participants (intervention = 353 and control = 266) reported cholesterol as an outcome measure FIGURE 1 Forest plot of randomized controlled trials investigating the effects of saffron on [Colour figure can be viewed at wileyonlinelibrary. com] (Abedimanesh et al, 2017;Azimi et al, 2014;Fadai et al, 2014;Javandoost et al, 2017;Kermani, Kazemi, et al, 2017;Kermani, Zebarjadi, et al, 2017;Mansoori et al, 2011;Milajerdi et al, 2018;Modaghegh et al, 2008;Mohamadpour et al, 2013;Nikbakht-Jam et al, 2016;Sepahi et al, 2018). Pooled results from the randomeffects model showed that cholesterol levels reduced in the intervention group compared with the control group (WMD: −6.36 mg/ dl, 95% CI [−10.58, −2.18]).…”

Section: Cholesterolmentioning

confidence: 99%

“…Pooled results from 15 studies (Abedimanesh et al, 2017;Azimi et al, 2014;Fadai et al, 2014;Javandoost et al, 2017;Kermani, Kazemi, et al, 2017;Kermani, Zebarjadi, et al, 2017;Milajerdi et al, 2018;Modaghegh et al, 2008;Mohamadpour et al, 2013;Nikbakht-Jam et al, 2016;Sepahi et al, 2018) using the random-effects model indicated that saffron as intervention resulted in nonsignificant increase in HDL levels (WMD: 0.91 mg/dl, 95% CI [−0.13, 1.96]) with significant heterogeneity among the studies (p = .01).…”

Section: High-density Lipoproteinmentioning

confidence: 99%

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The effect of saffron on weight and lipid profile: A systematic review, meta‐analysis, and dose–response of randomized clinical trials

Rahmani

Manzari

Thompson

et al. 2019

Phytotherapy Research

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Plant derivatives such as carotenoids and phytosterols enrich foods have been shown to reduce plasma triglyceride (TG), low‐density lipoprotein (LDL) cholesterol, and cholesterol concentrations. The aim of this systematic review and meta‐analyses study was to investigate the effects of saffron on lipid profiles, reported in randomized controlled trials (RCTs). We performed a systematic electronic search in PubMed/MEDLINE, Cochrane, and SCOPUS to identify RCTs and screening of relevant articles references up to October 12, 2018. There were no language restrictions. We performed this systematic review and meta‐analysis according to the Preferred Items for Reporting of Systematic Reviews and Meta‐Analyses guidelines. We identified and analyzed 14 eligible studies in this meta‐analysis. Our study found a significant reduction in cholesterol and TG following saffron intervention (weighted mean difference [WMD]: −6.36 mg/dl, 95% confidence interval, CI, [−10.58, −2.18] and WMD: −5.37 mg/dl, 95% CI [−10.25, −0.48], respectively). There was no significant effect on weight and LDL concentration. A meta‐regression analysis showed that long‐term saffron intervention can increase the high‐density lipoprotein (HDL) levels. In conclusions, our study findings indicate some benefits of saffron on cholesterol, HDL, and TG compared with placebo. However, we recommend the conduct of adequately powered, high‐quality RCTs with short‐ and long‐term follow‐up, evaluating relevant clinical outcomes to allow for making definitive recommendations.

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Section: Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Quality Assessmentmentioning

confidence: 99%

Section: Cholesterolmentioning

confidence: 99%

Section: High-density Lipoproteinmentioning

confidence: 99%

See 3 more Smart Citations

The effect of saffron on weight and lipid profile: A systematic review, meta‐analysis, and dose–response of randomized clinical trials

Rahmani

Manzari

Thompson

et al. 2019

Phytotherapy Research

View full text Add to dashboard Cite

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Antidiabetic potential of saffron and its active constituents

Yaribeygi

Zare

Butler³

et al. 2018

Journal Cellular Physiology

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The prevalence of diabetes mellitus is growing rapidly worldwide. This metabolic disorder affects many physiological pathways and is a key underlying cause of a multitude of debilitating complications. There is, therefore, a critical need for effective diabetes management. Although many synthetic therapeutic glucose‐lowering agents have been developed to control glucose homeostasis, they may have unfavorable side effects or limited efficacy. Herbal‐based hypoglycemic agents present an adjunct treatment option to mitigate insulin resistance, improve glycemic control and reduce the required dose of standard antidiabetic medications. Saffron (Crocus sativus L.), whilst widely used as a food additive, is a natural product with insulin‐sensitizing and hypoglycemic effects. Saffron contains several bioactive β carotenes, which exert their pharmacological effects in various tissues without any obvious side effects. In this study, we discuss how saffron and its major components exert their hypoglycemic effects by induction of insulin sensitivity, improving insulin signaling and preventing β‐cell failure, all mechanisms combining to achieve better glycemic control.

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Effects of saffron (Crocus sativus L.) supplementation on inflammatory biomarkers: A systematic review and meta‐analysis

Asbaghi

Sadeghian

Sadeghi

et al. 2020

Phytotherapy Research

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The effect of saffron supplementation on subclinical inflammation remains inconclusive. We performed a systematic review and meta‐analysis to summarize available findings on the effect of saffron supplementation on inflammatory biomarkers (C‐reactive protein [CRP], tumor necrosis factor‐α [TNF‐α], and interleukin‐6 [IL‐6]) in adults. We searched PubMed/Medline, Scopus, Web of Science, and Google Scholar databases up to November 2019 using relevant keywords to identify eligible trials. All randomized controlled trials (RCTs) that examined the effect of oral saffron supplementation on plasma concentrations of CRP, TNF‐α, and IL‐6 were included. For each outcome, mean differences and SDs were pooled using a random‐effects model. Overall, eight RCTs were included in this meta‐analysis. The pooled results showed that saffron supplementation did not result in significant changes in serum CRP (weighted mean difference [WMD]: −0.43 mg/L; 95% confidence interval [CI]: −1.04 to 0.17; p = .16), serum TNF‐α (WMD: −1.29 pg/mL; 95% CI: −4.13 to 1.55; p = .37), and IL‐6 concentrations (WMD: 0.11 pg/mL; 95% CI: −0.79 to 1.00; p = .81). Subgroup analysis indicated a significant reduction in serum CRP levels in studies with baseline CRP of ≥3 mg/L, saffron dosage of ≤30 mg/day, and intervention duration of <12 weeks, as well as trials that used crocin. Similarly, saffron was found to decrease TNF‐α in studies that recruited non‐diabetic subjects, subjects with baseline levels of ≥15 pg/mL, and participants with <50 years old, as well as trials that administered saffron at the dosage of ≤30 mg/day. We also found a significant non‐linear effect of saffron dosage on serum CRP concentrations (pnon‐linearity = .03). The overall results indicated that saffron supplementation did not affect inflammatory cytokines. Further high‐quality studies are needed to firmly establish the clinical efficacy of supplemental saffron on inflammatory biomarkers.

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Effects of Crocin on Diabetic Maculopathy: A Placebo-Controlled Randomized Clinical Trial

Cited by 88 publications

References 34 publications

The effect of saffron on weight and lipid profile: A systematic review, meta‐analysis, and dose–response of randomized clinical trials

The effect of saffron on weight and lipid profile: A systematic review, meta‐analysis, and dose–response of randomized clinical trials

Antidiabetic potential of saffron and its active constituents

Effects of saffron (Crocus sativus L.) supplementation on inflammatory biomarkers: A systematic review and meta‐analysis

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