Effects of creative expression program on the event-related potential and task reaction time of elderly with mild cognitive impairment

Abstract

Objectives This study aimed to evaluate the effects of a 16-week creative expression intervention program (CrExp) on the event-related potential (ERP) and task reaction time in older individuals with mild cognitive impairment (MCI). Methods This study is a randomized controlled clinical trial conducted in the Memory Center of Fujian Provincial hospital. Thirty-six MCI patients were randomly distributed into two groups. One group underwent a 16-week creative expression program (CrExp, n = 18) and the other performed as a control group (CG, n = 18) by general social activities. The amplitude and latency of ERP-P300 from the central (Cz), parietal (Pz), frontal (Fz) cortices and task reaction time (RT) were assessed at baseline, post-interventi on, and 24-week follow-up. Results The CrExp group showed greater differences than CG of P300 latency in Cz ( F = 4.37, P = 0.015), Pz ( F = 2.78, P = 0.009), Fz ( F = 6.45, P = 0.031) brain area after 16 weeks of intervention and in Fz ( F = 3.23, P = 0.028), Cz ( F = 3.79, P = 0.024), and Pz ( F = 5.60, P = 0.036) at 24 weeks follow-up. Also, we analyzed the task reaction time between two groups and found that a shorten reaction time at post-intervention ( F = 4.47, P = 0.011) and 24 weeks follow-up ( F = 3.12, P = 0.007) in the CrExp group. However, there was no difference in P300 amplitude in either brain area between the two groups. Conclusion The electrophysiological results of the creative expression cognitive therapy group were more obvious than those of the general cognitive therapy group, and the latency and task reaction time may be considered as supported parameters in diagnosing the effects during non-drug therapy intervention in clinical practice.

The Effects of a Magic Intervention Program on Cognitive Function and Neurocognitive Performance in Elderly Individuals With Mild Cognitive Impairment

“…Also, compared with healthy elderly individuals, the MCI cohort exhibited lower accuracy and slower reaction times when performing the Flanker task ( Luks et al, 2010 ; Wang et al, 2013 ) which corresponded to anomalies in the DLPFC and the ACC ( Luks et al, 2010 ). Previous studies have shown that a 16-week creative expression program consisting of creative storytelling activities of 60 min/session facilitated by a group of professional therapists could shorten the reaction times when performing the auditory oddball paradigm ( Zhao et al, 2020 ). In the present study, the magic intervention program also significantly improved the accuracy and reaction time performance in patients with MCI when performing the Flanker task, suggesting that this cognitive intervention mode facilitated by the magic intervention may enhance the attention and the efficiency of cognitive processing related to inhibitory control in elderly people with MCI ( Parris et al, 2009 ).…”

Effects of a staged integral art-based cognitive intervention (SIACI) program in older adults with cognitive impairments: protocol for a randomized controlled trial

“…In particular, the participants' functional brain activity during visuospatial working memory and executive tasks will be assessed by magnetic resonance imaging (MRI) in order to determine whether cognitive improvements in SIACI participants are associated with alterations in functional brain activation (which may underlie potential compensatory mechanisms that improve cognitive performance). In addition, effective interventions modify changes that are known to occur in neurodegenerative diseases (like AD), such as changes in neuroprotective growth factors (e.g., brain-derived neurotrophic factor [BDNF]) [33], inflammatory factors (e.g., interleukin [IL]-6 and tumor necrosis factor [TNF]-α) [34,35], AD-related pathological biomarkers (e.g., Aβ and phosphorylated tau) [36,37], cognition-related electrophysiological effects (e.g., eventrelated potential [ERP]-P300) [38], and reduced neurocognitive functions. We hypothesized that the 16-week, 24-session SIACI will effectively improve neurocognitive performance in older adults with CIs, potentially via divergent molecules (e.g., BDNF, IL-6, TNF-α, Aβ-42, Aβ-40, and phosphorylated and total tau) and neural pathways.…”

The effect of creative expression program in neurocognitive networks performance measured by task and resting-state functional MRI

“…Each session included 10 min of body-relaxing exercises, followed by 30 min of core cognitive strengthen items. More process information can be found in our previous publication (2021, Zhao et al ., 2018).…”