Effects of cranberry beverages on oxidative stress and gut microbiota in subjects with <i>Helicobacter pylori</i> infection: a randomized, double-blind, placebo-controlled trial

Gao, Tao; Hou, Meiling; Zhang, Bo; Pan, Xin; Liu, Chengxia; Sun, Chongxiu; Jia, Mengru; Lin, Song Chang; Xiong, Ke; Ma, Aiguo

doi:10.1039/d1fo00467k

Cited by 10 publications

(6 citation statements)

References 64 publications

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“…Cochrane's risk-of-bias tool for randomized trials is a standard tool used to evaluate the quality of RCTs [18]. Two authors individually assessed each included study using the following seven main aspects of the Cochrane risk-of-bias tool one by one: (1) random sequence generation (selection bias); (2) allocation concealment (selection bias); (3) blinding of participants and personnel (performance bias); (4) blinding of outcome assessment (detection bias); (5) incomplete outcome data (attrition bias); (6) selective reporting (reporting bias); (7) other bias. Based on the evaluation criterion of Cochrane's recommendations, the overall risk-of-bias judgment of each aspect was classified as "high risk", "unclear risk", and "low risk".…”

Section: Quality Assessment Of Meta-analysismentioning

confidence: 99%

“…The role of cranberry in preventing urinary tract infections in both adults and children has been widely acknowledged [ 3 ]. Some researchers now believe that cranberry can protect against cardiovascular diseases, reduce the risk of various cancers and metabolic diseases, and even prevent tooth decay, periodontitis, and Helicobacter pylori [ 2 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Cranberry Consumption on Glycemic and Lipid Profiles in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Li,

Chen,

Xia

et al. 2024

Nutrients

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This study aims to update the evidence and clarify whether cranberry possesses lipid-lowering and hypoglycemic properties in humans. PubMed, Web of Science, and Scopus were searched to identify relevant articles published up to December 2023. In total, 3145 publications were reviewed and 16 of them were included for qualitative synthesis and meta-analysis. Stata 15.0 and Review Manager 5.4 were applied for statistical analyses. The results revealed a significant decrease in the total cholesterol to high-density lipoprotein cholesterol ratio (TC/HDL-C) (MD = −0.24; 95% CI: −0.45, −0.04; peffect = 0.02) and homeostasis model assessment of insulin resistance (HOMA-IR) (MD = −0.59; 95% CI: −1.05, −0.14; peffect = 0.01) with cranberry consumption. However, it did not influence total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), fasting blood glucose (FBG), glycated hemoglobin (HbA1c), and fasting insulin. In subgroup analysis, cranberry consumption in dried form (capsules, powder, and tablets) was found to significantly decrease the fasting insulin level (three studies, one hundred sixty-five participants, MD = −2.16; 95% CI: −4.24, −0.07; peffect = 0.04), while intervention duration, health conditions, and dosage of polyphenols and anthocyanins had no impact on blood lipid and glycemic parameters. In summary, cranberry might have potential benefits in regulating lipid and glucose profiles.

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Section: Quality Assessment Of Meta-analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effects of Cranberry Consumption on Glycemic and Lipid Profiles in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Li,

Chen,

Xia

et al. 2024

Nutrients

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“…salivarius on microbial counts and survival to in vitro digestion, where the results indicated that the inhibition of H. pylori growth was produced in all juices. Recently, Gao et al [ 98 ] studied the effect of cranberry juice consumption (240 and 480 mL of juice, and 480 mL of placebo) on oxidative stress biomarkers and patients affected by H. pylori infection. The blood results indicated that cranberry juice remodeled the gut microbiota of the hospitalized patients, since the juice decreased the growth of H. pylori .…”

Section: Anti- Helicobacter Pylori Effects Of Plant-based Polyphenolsmentioning

confidence: 99%

Plant-Based Polyphenols: Anti-Helicobacter pylori Effect and Improvement of Gut Microbiota

2022

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Helicobacter pylori (H. pylori) infection affects more than half of the world’s population, and thus, about 10 to 20% of people with H. pylori suffer from peptic ulcers, which may ultimately lead to gastric cancer. The increase in antibiotic resistance and susceptibility has encouraged the search for new alternative therapies to eradicate this pathogen. Several plant species are essential sources of polyphenols, and these bioactive compounds have demonstrated health-promoting properties, such as the gut microbiota stimulation, inflammation reduction, and bactericidal effect. Therefore, this review aims to discuss the potential effect of plant-based polyphenols against H. pylori and their role in the gut microbiota improvement.

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“…Cranberry ( Vaccinium macrocarpon ) is a natural food and medicinal plant that has attracted much attention in recent years because of its unique health and medicinal effects. It is currently widely used in powder and extract forms in a variety of food and nutritional supplements ( 19 , 20 ). Some studies have shown that high concentrations of cranberry polyphenols are associated with antibacterial, antiviral, anti-inflammatory and antioxidant properties ( 21–24 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of cranberry powder on the diversity of microbial communities and quality characteristics of fermented sausage

et al. 2023

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Fermented sausage is popular with many consumers because of its distinctive flavor, but the safety of it has attracted widespread attention. At present, nitrite is widely used in fermented meat products because of its ideal color and bacteriostatic effect, but nitrite can be transformed into nitrosamines, which cause strong carcinogenic effects. Therefore, it is urgent to actively explore safe and efficient nitrite substitutes. In this study, cranberry powder was selected as a natural substitute for nitrite during the production of fermented sausage due to its unique antioxidant and bacteriostatic properties. The results showed that adding an appropriate amount of cranberry powder (5 g/kg) promoted a better color of the fermented sausage and promoted the accumulation of aromatic compounds. Furthermore, Pediococcus and Staphylococcus became the dominant species, accounting for more than 90% in all samples. According to the Pearson correlation analysis, Staphylococcus and Pediococcus had positive effects on the quality characteristics of fermented sausage products. This study provided the latest information on the application of cranberry powder as a natural substitute for nitrite in the process of manufacturing fermented sausage, and it also introduced an advanced solution to improve the quality characteristics and safety of fermented sausage products during processing.

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Effects of cranberry beverages on oxidative stress and gut microbiota in subjects with Helicobacter pylori infection: a randomized, double-blind, placebo-controlled trial

Abstract: Helicobacter pylori-induced oxidative stress plays an important role in gastric diseases. H. pylori disturbs gut microbiota. The objective is to investigate the effects of cranberry beverages on oxidative stress biomarkers...

Cited by 10 publications

References 64 publications

The Effects of Cranberry Consumption on Glycemic and Lipid Profiles in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

The Effects of Cranberry Consumption on Glycemic and Lipid Profiles in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Plant-Based Polyphenols: Anti-Helicobacter pylori Effect and Improvement of Gut Microbiota

Effects of cranberry powder on the diversity of microbial communities and quality characteristics of fermented sausage

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