Effects of COVID-19 on the Musculoskeletal System: Clinician’s Guide

Hasan, Laith K; Deadwiler, Brittney; Haratian, Aryan; Bolia, Ioanna K; Weber, Alexander E.; Petrigliano, Frank A.

doi:10.2147/orr.s321884

Cited by 42 publications

(61 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Необходимо отметить, что большинство исследователей объединяют миалгию и артралгию в единый симптомокомплекс. В крупном исследовании, включавшем 12 046 пациентов, миалгия и / или артралгия присутствовали у 15,5 % пациентов с коронавирусной инфекцией [13].…”

Section: частота артралгии и миалгии в остром периоде Covid-19 и при ...unclassified

“…Известно, что SARS-CoV-2 использует для проникновения в клетки и репликации рецептор ангиотензинпревращающего фермента 2, присутствующий во многих типах тканей, включая гладкие мышцы, синовиальную ткань и хрящ. Данный фермент выполняет множество функций, в частности противовоспалительную, ограничивает резорбцию костной ткани [13,16]. Однако результаты аутопсии пациентов, инфицированных SARS-CoV-2, не подтверждали наличие вируса в скелетных мышцах, а также в синовии при артрите, что свидетельствует о других возможных механизмах повреждения указанных тканей [17,18].…”

Section: механизмы артралгии и миалгии при коронавирусной инфекцииunclassified

“…Ранее было показано, что в раз-витии мышечной боли важную роль играет интерлейкин-6 (IL-6) [19,20]. Кроме того, возникающее при COVID-19 повышение уровня цитокинов и сигнальных молекул, таких как интерферон γ (IFN-γ), IL-1β, IL-6, IL-8, IL-17 и фактор некроза опухолей α (TNF-α), влияет на скелетные мышцы, вызывая протеолиз волокон и снижение синтеза белка [13]. В результате гиперэкспрессии цитокинов усиливается выработка простагландина Е2, который, воздействуя на периферические болевые рецепторы, может вызывать боль в мышцах [21].…”

Section: механизмы артралгии и миалгии при коронавирусной инфекцииunclassified

“…Вероятно, что причинами вирус-ассоциированной артралгии являются транзиторные синовиты или энтезопатии [22]. Также было показано, что IL-1β, IL-17 и TNF-α способствуют развитию тендопатии вследствие нарушения биологической активности теноцитов [13].…”

Section: механизмы артралгии и миалгии при коронавирусной инфекцииunclassified

See 3 more Smart Citations

Musculoskeletal manifectations of the new coronavirus infection: focus on arthralgia and myalgia

Клименко

Демидова

et al. 2022

Klinicist

View full text Add to dashboard Cite

The new coronavirus infection (COVID-19) is associated with a wide spectrum of various clinical manifestations including involvement of the musculoskeletal system which can persist for a long time after the infection. Supposedly, pathogenesis of musculoskeletal manifestations of COVID-19 is primarily caused by systemic inflammation accompanied by cytokine hyperexpression (interferon γ, interleukins 1β, 6, 8, 17, tumor necrosis factor α), as well as hypoxia leading to overproduction of inflammatory cytokines, activation of bone reabsorption by osteoclasts and subsequent decrease of mineral bone density and osteonecrosis in some cases. Additionally, some drugs prescribed to patients with COVID-19 (some antiviral drugs and glucocorticoids) should also be taken into account as they can lead to development of musculoskeletal pathology. In the acute period of COVID-19, myalgias are common, but in rare cases myositis with proximal muscular weakness and increased levels of creatine phosphokinase, lactate dehydrogenase can occur. Arthralgias in the acute period of COVID-19 are rarer than myalgias. In the studies of clinical manifestation of COVID-19, frequency of arthralgias and myalgias in the acute period is between 15.5 and 50 %. After COVID-19, frequency of arthralgias and myalgias gradually decreases, however there are cases of long-term joint and muscle pains, as well as post-viral arthritis, development of arthritis in the context of various autoimmune disorders. Myalgias and arthralgias during COVID-19 usually regress spontaneously and in most patients do not require prescription of antipain medications, but in some cases pain management is necessary. Use of non-steroid anti-inflammatory drugs and vitamin D during COVID-19 is a safe and effective method of pain management, including myalgia and arthralgia. Rehabilitation programs play an important role in improvement of functional state and patient recovery after moderate and severe COVID-19.

show abstract

Section: частота артралгии и миалгии в остром периоде Covid-19 и при ...unclassified

Section: механизмы артралгии и миалгии при коронавирусной инфекцииunclassified

See 2 more Smart Citations

Musculoskeletal manifectations of the new coronavirus infection: focus on arthralgia and myalgia

Клименко

Демидова

et al. 2022

Klinicist

View full text Add to dashboard Cite

show abstract

“…Myalgia, atrophy and sarcopenia are part of the musculoskeletal manifestations' spectrum [20]. Fatigue has also been reported as one of the symptoms encountered in both the acute phase and "long covid spectrum" [21]. Fatigue in relation to COVID-19 has been linked to general fatigue as a subjective complaint and was identified with subjective means on the Chalder Fatigue Scale (CFQ-11) [22].…”

Section: Introductionmentioning

confidence: 99%

A Custom-Made Electronic Dynamometer for Evaluation of Peak Ankle Torque after COVID-19

Popescu

Petrița

Alexa

et al. 2022

Sensors

View full text Add to dashboard Cite

The negative effects of SARS-CoV-2 infection on the musculoskeletal system include symptoms of fatigue and sarcopenia. The aim of this study is to assess the impact of COVID-19 on foot muscle strength and evaluate the reproducibility of peak ankle torque measurements in time by using a custom-made electronic dynamometer. In this observational cohort study, we compare two groups of four participants, one exposed to COVID-19 throughout measurements and one unexposed. Peak ankle torque was measured using a portable custom-made electronic dynamometer. Ankle plantar flexor and dorsiflexor muscle strength was captured for both feet at different ankle angles prior and post COVID-19. Average peak torque demonstrated no significant statistical differences between initial and final moment for both groups (p = 0.945). An increase of 4.8%, p = 0.746 was obtained in the group with COVID-19 and a decrease of 1.3%, p = 0.953 was obtained in the group without COVID-19. Multivariate analysis demonstrated no significant differences between the two groups (p = 0.797). There was a very good test–retest reproducibility between the measurements in initial and final moments (ICC = 0.78, p < 0.001). In conclusion, peak torque variability is similar in both COVID-19 and non-COVID-19 groups and the custom-made electronic dynamometer is a reproducible method for repetitive ankle peak torque measurements.

show abstract

Muscle dysfunction in the long coronavirus disease 2019 syndrome: Pathogenesis and clinical approach

Silva

Bichara

Carneiro

et al. 2022

Reviews in Medical Virology

View full text Add to dashboard Cite

In long coronavirus disease 2019 (long COVID‐19), involvement of the musculoskeletal system is characterised by the persistence or appearance of symptoms such as fatigue, muscle weakness, myalgia, and decline in physical and functional performance, even at 4 weeks after the onset of acute symptoms of COVID‐19. Muscle injury biomarkers are altered during the acute phase of the disease. The cellular damage and hyperinflammatory state induced by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection may contribute to the persistence of symptoms, hypoxaemia, mitochondrial damage, and dysregulation of the renin‐angiotensin system. In addition, the occurrence of cerebrovascular diseases, involvement of the peripheral nervous system, and harmful effects of hospitalisation, such as the use of drugs, immobility, and weakness acquired in the intensive care unit, all aggravate muscle damage. Here, we review the multifactorial mechanisms of muscle tissue injury, aggravating conditions, and associated sequelae in long COVID‐19.

show abstract

Effects of COVID-19 on the Musculoskeletal System: Clinician’s Guide

Cited by 42 publications

References 97 publications

Musculoskeletal manifectations of the new coronavirus infection: focus on arthralgia and myalgia

Musculoskeletal manifectations of the new coronavirus infection: focus on arthralgia and myalgia

A Custom-Made Electronic Dynamometer for Evaluation of Peak Ankle Torque after COVID-19

Muscle dysfunction in the long coronavirus disease 2019 syndrome: Pathogenesis and clinical approach

Contact Info

Product

Resources

About