Effects of coumestrol administration to maternal mice during pregnancy and lactation on renal Ca metabolism in neonatal mice

Ueda, Michihisa; Horiguchi, Yoshihiro; Sugimoto, Miki; Ikeda, Shuntaro; Kume, Shinji

doi:10.1111/j.1740-0929.2011.00977.x

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…Additionally, legumes contain high levels of phytoestrogen and K, and phytoestrogen administration to maternal mice during pregnancy and lactation affected renal Ca metabolism in male neonatal mice via maternal milk (Ueda et al . ). Further study is needed to clarify the effects of high K diets on kidney function in lactating animals, because the exact mechanism of high KCl diets for preventing kidney function in maternal and neonatal mice is still unclear.…”

Section: Discussionmentioning

confidence: 97%

Effects of high potassium chloride supplementation on water intake and bodyweight gains in pregnant and lactating mice

Murai

Shukuin

Sugimoto

et al. 2013

Animal Science Journal

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Thirty-one ICR pregnant mice were assigned to a control or a potassium chloride (KCl) diet group to clarify the effects of KCl supplementation on water intake, bodyweight gains and serum components in pregnant and lactating mice, and 5% KCl was supplemented in KCl diets from 6.5 days post coitus to 1 or 14 days after parturition. Feed intake was not affected by treatment, but supplemental KCl decreased bodyweight gains of lactating mice and their neonatal mice. Water intake and urine volume of KCl supplemented mice were significantly higher than those of control mice during pregnancy and supplemental KCl decreased serum urea N in pregnant mice. Supplemental KCl increased water intake drastically in lactating mice immediately after parturition and increased serum K at 14 days after parturition. Histological alteration using hematoxylin-eosin was not found in the kidney of each mouse at 1 or 14 days after parturition. These results indicate that high KCl supplementation accelerates water intake in lactating mice and prevents bodyweight gains of maternal and neonatal mice during lactation.

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Section: Discussionmentioning

confidence: 97%

Effects of high potassium chloride supplementation on water intake and bodyweight gains in pregnant and lactating mice

Murai

Shukuin

Sugimoto

et al. 2013

Animal Science Journal

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“…Coumestrol is a phytoestrogen and has various physiological effects through ERs (Morito et al 2002). Our previous studies (Kirihata et al 2008(Kirihata et al , 2011Ueda et al 2012) indicated that the administration of coumestrol at a dose of 200 mg/kg body weight for pregnant and lactating mice, which is based on less than half the recommended threshold intake for isoflavones by the Ministry of Health, Labour and Welfare of Japan (Tokyo, Japan), decreased the activity of alkaline phosphatase in maternal duodenum around parturition and affected renal Ca metabolism in male neonatal mice at 11 days post partum (dpp).…”

Section: Introductionmentioning

confidence: 99%

Effects of coumestrol administration to maternal mice during pregnancy and lactation on immunoblogulin A‐secreting cells in mammary glands

Wang

Sugimoto

Ikeda

et al. 2012

Animal Science Journal

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Mortality and morbidity of neonates continue to be major problems in humans and animals, and immunoblogulin A (IgA) provides protection against microbial antigens at mucosal surfaces. The present study was conducted to clarify the effects of coumestrol administration to maternal mice during pregnancy and lactation on IgA antibody-secreting cells (ASC) in mammary glands in lactating mice. From 6.5 to 16.5 days post coitus and 1 to 13 days post partum (dpp), maternal mice were administered coumestrol at 200 μg/kg body weight/day. Coumestrol administration increased the number of IgA ASC and the messenger RNA expression of IgA C-region and vascular cell adhesion molecule-1 in mammary glands of maternal mice at 14 dpp, but coumestrol administration had no effect on the number of IgA ASC in the ileum. Coumestrol administration increased serum IgA concentration in maternal mice at 14 dpp, but IgA concentrations in serum, stomach contents, intestine and feces of neonatal mice were not affected by treatment. These results imply that coumestrol administration to maternal mice during pregnancy and lactation is effective in increasing the numbers of IgA ASC in mammary glands during lactation owing to the activated messenger RNA expressions of IgA C-region and vascular cell adhesion molecule-1 in mammary gland.

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“…In ovariectomized rats, uterine weight (wet and dry) was increased by coumestrol which has relatively weak binding affinities for estrogen receptors as compared to estradiol (Markaverich et al, ). Moreover, coumestrol administration to mice during pregnancy and lactation increased production of immunoglobulin A that is a key factor for enhancing the fetal immune system response to microbial antigens in milk (Wang et al, ) and it influenced calcium metabolism in kidneys of neonatal mice through actions via estrogen receptor alpha (Ueda et al, ). Although coumestrol has a wide spectrum of biological activities, its influence on conceptus development has not been elucidated.…”

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confidence: 99%

Stimulatory Effects of Coumestrol on Embryonic and Fetal Development Through AKT and ERK1/2 MAPK Signal Transduction

Lim

Song

2016

Journal Cellular Physiology

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Successful establishment of pregnancy is required for fetal-maternal interactions regulating implantation, embryonic development and placentation. A uterine environment with insufficient growth factors and nutrients increases the incidence of intrauterine growth restriction (IUGR) leading to an impaired uterine environment. In the present study, we demonstrated the effects of the phytoestrogen coumestrol on conceptus development in the pig that is regarded as an excellent biomedical animal model for research on IUGR. Results of this study indicated that coumestrol induced migration of porcine trophectoderm (pTr) cells in a concentration-dependent manner. In response to coumestrol, the phosphorylation of AKT, P70S6K, S6, ERK1/2 MAPK, and P90RSK proteins were activated in pTr cells and ERK1/2 MAPK and P90RSK phosphorylation was prolonged for a longer period than for the other proteins. To identify the signal transduction pathway induced by coumestrol, pharmacological inhibitors U0126 (an ERK1/2 inhibitor) and LY294002 (a PI3K inhibitor) were used to pretreat pTr cells. The results showed that coumestrol-induced phosphorylation of ERK1/2 MAPK and P90RSK was blocked by U0126. In addition, the increased phosphorylation in response to coumestrol was completely inhibited following pre-treatment incubation of pTr cells in the presence of LY294002 and U0126. Furthermore, these two inhibitors suppressed the ability of coumestrol to induce migration of pTr cells. Collectively, these findings suggest that coumestrol affects embryonic development through activation of the PI3K/AKT and ERK1/2 MAPK cell signal transduction pathways and improvement in the uterine environment through coumestrol supplementation may provide beneficial effects of enhancing embryonic and fetal survival and development. J. Cell. Physiol. 231: 2733-2740, 2016. © 2016 Wiley Periodicals, Inc.

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Effects of coumestrol administration to maternal mice during pregnancy and lactation on renal Ca metabolism in neonatal mice

Cited by 3 publications

References 24 publications

Effects of high potassium chloride supplementation on water intake and bodyweight gains in pregnant and lactating mice

Effects of high potassium chloride supplementation on water intake and bodyweight gains in pregnant and lactating mice

Effects of coumestrol administration to maternal mice during pregnancy and lactation on immunoblogulin A‐secreting cells in mammary glands

Stimulatory Effects of Coumestrol on Embryonic and Fetal Development Through AKT and ERK1/2 MAPK Signal Transduction

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