“…Such putative imbalance might take any of a variety of forms: for example, it could involve the uncoupling of processes that lead to the initiation of DNA synthesis (unpublished observations). Caffeine has been reported to perturb a multitude of metabolic processes; these include replication and repair of DNA in prokaryotic and eukaryotic cells (e.g., Grigg, 1968Grigg, , 1972Lehmann, 1972;Lehmann and Kirk-Bell, 1974;Tatsumi and Strauss, 1979;Painter, 1980) as well as the action of specific enzymes concerned with DNA synthesis, such as DNA polymerase I (Solberg et al, 19781, thymidine kinase (Sandlie et al, 19801, and a number of purine-metabolizing enzymes (Koch and Lamont, 1956;Nolan and Kidder, 1979). In addition, it binds to DNA, presumably in single-strand regions (Ts'o and Lu, 1964).…”