Effects of Corticosteroids on Coagulation of the Blood

Özsoylu, Şînasi; Strauss, Herbert S.; Diamond, Louis K.

doi:10.1038/1951214a0

Cited by 139 publications

(70 citation statements)

References 7 publications

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“…The suggestion that corticosteroids may be of value in the treatment of myocardial infarction (Baroody and Baroody, 1965;Dall and Buchanan, 1962) has been disputed. Our results suggest that the hypercoagulability of blood reported in patients on corticosteroids (Ozsoylu, Strauss, and Diamond, 1962;Eisenmenger, Slater, and Bongiovanni, 1952) was not of clinical significance. Arteritis due to underlying disease may well have been blamed on corticosteroids in the past (Bywaters and Scott, 1963;Parker and Thomas, 1959 (Murray and Sladden, 1965) among the treated was in a patient with generalized aspergillosis at necropsy.…”

Section: Incidence Of Complications In Corticosteroid-treated and Conmentioning

confidence: 58%

Incidence of serious complications of corticosteroid therapy in respiratory disease: A retrospective survey of patients in the Brompton Hospital

Smyllie

Connolly

1968

Thorax

112

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A retrospectively controlled study is described of mortality and serious morbidity in 550 patients treated with corticosteroids and 499 controls. The overall incidence of side-effects was similar in both groups, but gastro-intestinal bleeding, diabetes, and mental disturbance early in treatment occurred more frequently in the corticosteroid group. Other individual side-effects did not occur significantly more often than in the controls, but there was an overall increased frequency of complications with increased dose, and also an increased mortality with increase in the maintenance dose. Gastro-intestinal bleeding was not related to a past or present chronic peptic ulcer, and was not commoner in treated patients. Reactivation of tuberculosis and exacerbation of mental disturbance did not occur. Weight gain occurred in 29% of patients, but appeared to be related closely to a satisfactory response to treatment. Hypertension occurred in 4% of the treated group. Overall mortality in the two groups was similar. Mortality due specifically to corticosteroids was difficult to assess: two patients died of haematemesis and three died with severe asthma during withdrawal of treatment, but there was no increase in mortality following physical stress in the treated series. Sudden death in asthmatics was not more frequent in corticosteroid-treated patients. All seven control patients who died suddenly with asthma were middleaged. Increase in duration of treatment was not associated with increased risk. Indeed the longterm, low-dose group had a lower incidence of complications than the rest and a mortality similar to that of the controls. A trial of corticosteroids for less than one month carried no risk in 41 patients.

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Section: Incidence Of Complications In Corticosteroid-treated and Conmentioning

confidence: 58%

Incidence of serious complications of corticosteroid therapy in respiratory disease: A retrospective survey of patients in the Brompton Hospital

Smyllie

Connolly

1968

Thorax

112

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“…Ozsoylu y cols. 16 sugieren que los corticoides inducirian aumento del factor VIII y de otras protemas sericas, que favorccen el estado de hipercoagulabilidad. Liberman 17 menciona una disminucion de la actividad fibrinoh'tica durante el tratamiento esteroidal y sugiere que existiria una lisis incomplcta del trombo, favoreciendo de esta manera un aumento en el deposito de fibrina y plaquetas.…”

Section: Discusionunclassified

Trombosis Venosa Profunda en el Síndrome Nefrótico

Ma¹,

Solar²,

Lagomarsino³

et al. 1986

Rev. chil. pediatr.

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“…26 Prednisolone has been associated with an increase in FVIII, vWF and PAI-1. 27,28 Dexamethasone has been shown to cause a modest but clear rise in the activity of FVII, FVIII, FIX and fibrinogen in healthy volunteers, but to have no significant effect on PAI-1. 29 The use of corticosteroids during inflammatory states has been consistently associated with reduced levels of vWF and fibrinogen but increased PAI-1.…”

Section: Effect Of Corticosteroidmentioning

confidence: 99%