Effects of cortical spreading depression and ether following one-trial discriminated avoidance learning

Black, Manuel; Suboski, Milton D.; Freedman, Nelson L.

doi:10.3758/bf03327907

Cited by 9 publications

(2 citation statements)

References 5 publications

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“…Procedure. The pretraining procedure was the same as that described by Black et al (1967). The Ss were given a series of four daily trials in which they were placed in the open field and allowed to enter one of the small chambers.…”

Section: Methodsmentioning

confidence: 99%

“…As has previously been pointed out Pfingst & King, 1967), discriminated avoidance permits separation of performance and retention effects of experimental manipulations. We have reported investigations of ether following one-trial discriminated avoidance training (Black, Suboski, & Freedman, 1967) with equivocal results. We report a similar experiment here, except that heated ether, two learning-ether intervals, and both passive and discriminated avoidance testing were used.…”

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Further on the effects of ether anesthesia following one-trial discriminated avoidance learning

1968

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Section: Methodsmentioning

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Further on the effects of ether anesthesia following one-trial discriminated avoidance learning

1968

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The effect of prolonged cortical spreading depression on learning and memory in rats

Burešová

Bureš

1969

J. Neurobiol.

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SUMMARYMemory impairment evoked by prolonged cortical spreading depression (PCSD) was examined in 387 rats. PCSD was maintained for 5 hrs by repeated applications of 25 ' % KCl to the exposed cortical surface.Behavioral tests were performed 24 or more hours after PCSD. Whereas a single application of 25% KCl does not affect subsequent learning, acquisition of a simple T-maze avoidance reaction is slower and exploration of a novel environment is impaired during 3-5 days following PCSD. The effect of CSD on the memory depends on the total duration of the depression. While a single KC1 application has a negligible amnesic effect, PCSD prevents later retrieval of moderately overlearned (tocriterion learning on 3 consecutive days) T-maze habit but does not affect markedly overlearned behavior (to-criterion learning on 12 consecutive days). Similarly PCSD impairs the exploration of a novel but not of a familiar environment. Even moderately overlearned habits remain unaffected by PCSD applied 7-12 days after completion of learning. The amnesic effects of PCSD are not permanent, retrieval of the impaired experience improves over 7-14 days to control level. Since spontaneous EEG and evoked responses are more or less normal 24 hr after PCSD, it is proposed that PCSD interferes with the metabolic phase of engram formation. The relative significance of the components of the PCSD effect affecting learning and memory is discussed.

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The Role of Genotype in Behavioral Responses to Anesthetics

Elias

Pentz

1975

Psychopharmacogenetics

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Effects of cortical spreading depression and ether following one-trial discriminated avoidance learning

Cited by 9 publications

References 5 publications

Further on the effects of ether anesthesia following one-trial discriminated avoidance learning

Further on the effects of ether anesthesia following one-trial discriminated avoidance learning

The effect of prolonged cortical spreading depression on learning and memory in rats

The Role of Genotype in Behavioral Responses to Anesthetics

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