Effects of cortical lesions on tactile discriminations graded in difficulty

Finger, Stanley; Frommer, Gabriel P.

doi:10.1016/0024-3205(68)90164-1

Cited by 33 publications

(14 citation statements)

References 6 publications

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“…3 For example, Finger and his associates (Finger, Cohen, & Alongi, 1972;Finger & Frommer, 1968;Gabrial, Freer, & Finger, 1979) have shown that occipital injuries in rats have little effect on either original learning or reversal learning of a tactile discrimination task. (Although nigrallesions have apparently not been examined in relation to acquisition of a tactile discrimination, parafascicular lesions have been reported to impede tactile discrimination learning-see Finger, 1972.…”

Section: The General Learning System Preliminary Findingsmentioning

confidence: 99%

Brain lesions impairing visual and spatial reversal learning in rats: Components of the “general learning system” of the rodent brain

Thompson

1982

Psychobiology

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The "general learning system" (GLS) is conceived as an ensemble of brain structures essential for normal acquisition of a wide variety of laboratory tasks. Based upon earlier lesion studies, it was reasoned that the components of the rodent's GLS could be identified by determining which lesion placements within the rat brain would lead to defective acquisition of a spatial discrimination habit and its reversal as well as a brightness discrimination habit and its reversal. Of the 11 cortical and subcortical (frontal cortex, parietal cortex, occipital cortex, anterior cingulate cortex, posterior cingulate cortex, rostral caudoputamen, dorsal hippocampus, mammillary bodies, mediodorsal thalamic nucleus, parafascicular nucleus, and substantia nigra) sites investigated in this experiment, only two qualified as components of the GLS-the parafascicular nucleus and the substantia nigra. The possibility that the nigro-parafascicular-striatal complex constitutes a major part of the rodent's GLS is discussed.

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Section: The General Learning System Preliminary Findingsmentioning

confidence: 99%

Brain lesions impairing visual and spatial reversal learning in rats: Components of the “general learning system” of the rodent brain

Thompson

1982

Psychobiology

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“…An olfactory confounding may, in part, account for the finding in an earlier report (Finger & Frommer, 1968a) in which some rats with large lesions in the somatosensory projections to the thalamus and cortex learned simple roughness discriminations as rapidly as did controls. A more re cent study (Finger & Frommer, 1968b) has shown that rats with larger and better localized lesions, tested with discriminanda that eliminated olfactory confouding (milled aluminum plates), had severe deficits in acquiring tactile discriminations. The findings reported in studies with abrasive discriminanda comparable to those used in the present investigation must be re~valuated, and future research should be conducted with plastic or metallic plates inscribed with different tactile features.…”

Section: Discussionmentioning

confidence: 99%

Roughness discrimination with sandpaper surfaces: An olfactory confounding

et al. 1970

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“…The enclosed singleunit T-maze had a startbox (36 x 23 x 14 cm) and two alleys (64 x 22 x 14 cm). On the floor of one alley was a smooth aluminum plate, and on the other was a "rough" aluminum plate (milled with spiral cuts of 0.5 mm made with a flying cutter (Finger & Frommer, 1968). A dish of food (ground Purina Rat Chow mixed with water) served as the reward.…”

Section: Methodsmentioning

confidence: 99%

Relation between the severity of early malnutrition and the effects of later frontal cortical lesions in rats

et al. 1985

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Rats with an early history of severe malnutrition received frontal cortical (FC) lesions or control operations at 90 days of age. These severely malnourished groups were compared with each other and with moderately malnourished and well-fed groups (FC and control) for acquisition and three reversals of a tactile discrimination (rough-smooth). Main effects of lesion and nutrition were found for acquisition and reversals. The groups with malnutrition plus frontal lesions displayed the poorest performance. Although the severely and moderately malnourished groups did not differ in acquisition of the discrimination, the severely malnourished group made more reversal errors. The severely malnourished rats also showed greater brain growth retardation (size and weight) than the moderately malnourished rats. These results indicate that the effects of early dietary history and the reaction to a later, acute brain injury may be additive under certain circumstances.

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Effects of cortical lesions on tactile discriminations graded in difficulty

Cited by 33 publications

References 6 publications

Brain lesions impairing visual and spatial reversal learning in rats: Components of the “general learning system” of the rodent brain

Brain lesions impairing visual and spatial reversal learning in rats: Components of the “general learning system” of the rodent brain

Roughness discrimination with sandpaper surfaces: An olfactory confounding

Relation between the severity of early malnutrition and the effects of later frontal cortical lesions in rats

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