Effects of Corsi-Rosenthal boxes on indoor air contaminants: non-targeted analysis using high resolution mass spectrometry

High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage

“…Note that sector GC-HRMS is designed for high sensitivity and selectivity with only a borderline high mass resolution (e.g., 10,000 by full width at half-maximum, fwhm at m / z 322, as offered by the Thermo Scientific DFS model); in fact, all 16 sector GC-HRMS analyses were targeted quantitation of trace pollutants such as dioxin and illicit drugs . NTA by GC-HRMS (Orbitrap or ToF), on the other hand, remains underexploited but has shown potential through successes in environmental monitoring (e.g., water, air, dust, and soil), food safety assessment, and biomonitoring. ,− Concerted efforts are warranted to bridge knowledge and technical gaps between these two platforms and, importantly, to expand the chemical space GC-HRMS covers. Technical specifics of feasibility and cost-effectiveness have been discussed for column choices, dimension/scale, MP modifiers, and operating temperature …”

“… 44 NTA by GC-HRMS (Orbitrap or ToF), on the other hand, remains underexploited but has shown potential through successes in environmental monitoring (e.g., water, air, dust, and soil), 139 food safety assessment, 140 and biomonitoring. 25 , 141 − 143 Concerted efforts are warranted to bridge knowledge and technical gaps between these two platforms and, importantly, to expand the chemical space GC-HRMS covers. Technical specifics of feasibility and cost-effectiveness have been discussed for column choices, dimension/scale, MP modifiers, and operating temperature.…”

Embracing novel thinking to safeguard against airborne pathogens in indoor spaces

“…During the COVID-19 pandemic the ‘do-it-yourself’ Corsi-Rosenthal box was used as a low-cost project to simultaneously improve ventilation and air-cleaning in classrooms and engaged a broader group of people in improving indoor air quality. 10 Groups like Clean Air Stars developed practical guidance for choosing room air cleaners, accounting for acceptable noise levels and room occupancy. 11 GUV systems have a strong evidence base for TB and offer significant promise as universal airborne IPC measures.…”