Effects of coronary artery bypass grafting on resting and exercise hemodynamics in patients with stable angina pectoris: A prospective, randomized study

Patterns of haemodynamic alteration during left ventricular ischaemia in man. Relation to angiographic extent of coronary artery disease.

“…It is clear that in some patients at least, namely in those who have a normal resting left ventricular ejection fraction, that the ischaemic fraction is composed totally of areas that have been dysfunctional acutely. Goldschlager et al (1970), Saltups et al (1971), and Barry et al (1976) also foundthat the proportion of patients having rises in left ventricular filling pressure during stress (exercise) increased as the extent of coronary artery disease increased, but in the first and second studies a minority of patients had angina, and no ventriculographic data were reported that would allow separation of the effects of acute ischaemia from those of chronic left ventricular functional impairment. Cannom et al (1974) and Roy et al (1975) interpreted the findings of their studies (spontaneous angina and pacing-induced angina, respectively) as showing no relation between the extent of coronary artery disease and haemodynamic changes occurring during ischaemia, but both studies included relatively small numbers of patients.…”

Use of exercise tests in assessment of the functional result of aortocoronary bypass surgery

“…[8][9][10][11][12][13][14][15][16][17][18][19][20] Using these methods, especially in patients with more than one bypass graft, it is difficult to determine which coronary lesions are the critical ones in any given patient. Similar difficulties have been experienced in the use of myocardial imaging during exercise; in patients with multi-vessel disease it has been difficult to detect all the disease sites.2' For example, a normal scan, at rest and during exercise, does not totally exclude an occluded graft, and a perfusion defect during exercise has been obtained when the grafts were patent.22 Thus, from these studies it is possible to conclude that a successful bypass in terms of anatomical patency of the grafts does not necesarily indicate functional improvement in oxygen availability to ischaemic regions of the myocardium, so that the functional effects cannot be predicted.…”

Determinants of Ventricular Performance after Coronary Artery Bypass Grafting

“…were from an earlier era [10][11][12][13][14][15][16][17], The purpose of this study was to assess both resting and exercise nuclear ejection fractions in a large number of consecutive pa tients undergoing coronary artery bypass grafting during a more recent era of improved myocardial revasculariza tion and myocardial protection methods.…”