Effects of Cordyceps sinensis, Cordyceps militaris and their isolated compounds on ion transport in Calu-3 human airway epithelial cells

Inhibition of TGF-β1/Smad signal pathway is involved in the effect of Cordyceps sinensis against renal fibrosis in 5/6 nephrectomy rats

“…The traditional medicine known as Chinese caterpillar fungus (Dongchong Xiacao) is composed of the parasitic fungus Cordyceps sinensis, which grows on the larva of the ghost moth Hepialus armoricanus Oberthur (Hepiallidae) (Yue et al, 2008). C. sinensis has a long history of medical use in China, beginning during the Qing dynasty in A.D. 1694.…”

Cordyceps Extracts and the Major Ingredient, Cordycepin: Possible Cellular Mechanisms of Their Therapeutic Effects on Respiratory Disease

“…Apical application of 300 μg/ml CM extract or 300 μM cordycepin stimulates the highest peak increase in I SC . The transport mechanisms involve both basolateral Na + -K + -2Cl -cotransporters and apical CFTR Cl -channels for the uptake and exit of Cl -, respectively (Yue et al, 2008). These data indicate for the first time that extracts of CS and CM, and cordycepin could stimulate transepithelial Cl -secretion and may therefore promote fluid secretion by human airway epithelial cells.…”

“…Cordycepin is a major bioactive component of CM and has been detected in different parts of the CM fruiting body, ranging from 0.16 to 0.25% (w/w) (Yue et al, 2008). In 16HBE14o-cells, apical or basolateral application of cordycepin resulted in a stimulation of I SC , which has been shown to be due to Cl -secretion (Fung et al, 2011).…”

Review on Pharmacologically Active Metabolites from Yarsagumba (Ophiocordyceps sinensis), an Epitome of Himalayan Elixir

“…As inflammation is also one of the hallmark of aging (Zhang et al 2013a) and presence of compounds like ergosterol peroxide (2), ergosteryl-3-O-â-Dglucopyranoside (4), stigmasterol (10), cordycepin (13), perlolyrine (17), and cordymin (18) with the antiinflammatory property can have role in anti-ageing effect of O. sinensis. Cordycepin is one of the most active compound with several activities (Yun et al 2003, Kim et al 2006, Holliday & Cleaver 2008, Yue et al 2008, Kim et al 2009, Leu et al 2011, Yang et al 2011, Xiao et al 2012. There is possibility of its role in synergetic effect with other compounds for several therapeutic effects.…”