In two separate experiments, Hydrangea macrophylla (Thunb.) Ser. ‘Merritt's Supreme’ plants were used to study the effects of foliar sprays of Def 6 (tributyl phosphorotrithioate, 2500, 5000, 7500, and 10,000 mg·L−1), gibberellic acid (GA, 50 mg·L−1), copper–EDTA (CuEDTA, 0.5% and 1.0%), Florel (2000 mg·L−1), and urea (3%) on defoliation in the fall and growth and flowering performance during forcing. Compared with controls (plants sprayed with water only), spraying plants with urea or GA alone had no influence on defoliation or plant performance during forcing, and spraying plants with Florel alone had no influence on defoliation but decreased total flower dry weight during forcing. Combining urea with Florel sprays decreased the adverse effects of Florel on plant quality and combining GA with Florel improved defoliation. Increasing concentrations of Def 6 and CuEDTA increased defoliation. Compared with controls, plants sprayed with CuEDTA exhibited more defoliation, showed bud and leaf necrosis, and produced lower flower dry weight during forcing. Combining urea with CuEDTA sprays decreased the adverse effects of CuEDTA on plant quality. Compared with controls, spraying plants with Def 6 increased defoliation, caused no visible damage to plants, and had no adverse effects on plant quality during forcing. Adding urea to sprays containing Def 6 decreased or had no influence on the efficiency of defoliation and increased total flower dry weight during forcing compared with Def 6 alone. Adding GA to sprays containing lower concentrations of Def 6 (2500 and 5000 mg·L−1) increased the efficiency of defoliation without adversely influencing plant quality.