Effects of Copper Coordinate Complexes on the Scavenging of Reactive Oxygen Species

Synthesis, characterization and potent superoxide dismutase-like activity of novel bis(pyrazole)–2,2′-bipyridyl mixed ligand copper(ii) complexes

“…We found that all five bipy-Cu(II) complexes demonstrated high SOD-like activity, with IC 50 values in the low micromolar range (0.8-1.7 μM). Although the bipy complexes were not as effective as horseradish SOD (Table 3) or bovine erythrocyte SOD (IC 50 =4×10 −8 )49, their activities were on the same order of magnitude as the best SOD analogs described in the literature 50-52. The lower k cat of Cu(NO 3 ) 2 compared with that of the bipy complexes suggests that the activity of the complexes was not due to their dissociation in solution.…”

“…Although the bipy complexes were not as effective as horseradish SOD (Table 3) or bovine erythrocyte SOD (IC 50 = 4 ¥ 10 -8 ) 49 , their activities were on the same order of magnitude as the best SOD analogs described in the literature. [50][51][52] The lower k cat of Cu(NO 3 ) 2 compared with that of the bipy complexes suggests that the activity of the complexes was not due to their dissociation in solution. It should be noted that ligands (L1-L7) did not exhibit any O 2 ∑scavenging effects over the same concentration range (0.1-100 mM) in the non-enzymatic O 2 ∑ --generating system (data not shown).…”

Strong protective action of Copper(II) N-substituted sulfonamide complexes against reactive oxygen species

“…Copper, zinc superoxide dismutase (Cu 2 Zn 2 SOD) is believed to protect the cell against oxidative damage and inflammation due to oxygen intermediates by the catalytic dismutation of superoxide radicals to oxygen molecules and hydrogen peroxide [4]. Decreases in the levels of Cu 2 Zn 2 SOD within a cell causes injuries to the cell [5]. Exogenous treatment of these cells with native SOD does not solve this problem because native SOD cannot penetrate through cell membrane.…”

Molecular structure, bioavailability and bioactivity of [Cu(o-phen)2(cnge)](NO3)2·2H2O and [Cu(o-phen)(cnge)(H2O)(NO3)2] complexes

“…The aim of this analysis is to obtain information about the bioavailability of these systems at different pH values (ionic strength 150 mM) and also to simulate naturally occurring mixtures of the metal ion and the ligands. Besides, it is demonstrated that some copper(II) complexes mimics the enzymatic action of the enzyme superoxide dismutase (SOD) that protects cells against peroxide radicals [17][18][19][20][21]. The SOD activities of both complexes have also been tested.…”