Effects of copper and zinc on ischemic heart disease and myocardial infarction: a Mendelian randomization study

Kodali, Hanish; Pavilonis, Brian; Schooling, CM

doi:10.1093/ajcn/nqy129

Cited by 35 publications

(30 citation statements)

References 33 publications

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“…We found strong genetic evidence that rs11144134 in the TRPM6 gene in our study was associated with lower Mg levels and with higher BMD [17], which increases the evidence to support a negative relationship between Mg and OP. Cu has antioxidant properties, being involved in metabolic processes and redox reactions in the central nervous system [13], and copper affects the evolution of cognitive impairment associated with AD and BD [35,37].…”

Section: Discussionmentioning

confidence: 99%

“…For example, an MR study indicates that obesity may be a risk factor for gout [11], and education levels are negatively related to AD risk [12]. Accordingly, Cu supplementation can effectively reduce the incidence and mortality of coronary heart disease [13], and elevated Ca levels increase the risk of migraine [14]. However, to our knowledge, the effects of minerals in chronic diseases have not been evaluated on a large scale with the use of MR. A two-sample analysis strategy may be employed in which evidence for the correlation between exposure factors (minerals) and outcome factors (chronic diseases) is taken from different samples [15].…”

Section: Introductionmentioning

confidence: 99%

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Mineral Nutrition and the Risk of Chronic Diseases: A Mendelian Randomization Study

2019

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We applied Mendelian randomization analyses to investigate the potential causality between blood minerals (calcium, magnesium, iron, copper, and zinc) and osteoporosis (OP), gout, rheumatoid arthritis (RA), type 2 diabetes (T2D), Alzheimer's disease (AD), bipolar disorder (BD), schizophrenia , Parkinson’s disease and major depressive disorder. Single nucleotide polymorphisms (SNPs) that are independent (r2 < 0.01) and are strongly related to minerals (p < 5 × 10−8) are selected as instrumental variables. Each standard deviation increase in magnesium (0.16 mmol/L) is associated with an 8.94-fold increase in the risk of RA (p = 0.044) and an 8.78-fold increase in BD (p = 0.040) but a 0.10 g/cm2 increase in bone density related to OP (p = 0.014). Each per-unit increase in copper is associated with a 0.87-fold increase in the risk of AD (p = 0.050) and BD (p = 0.010). In addition, there is suggestive evidence that calcium is positively correlated (OR = 1.36, p = 0.030) and iron is negatively correlated with T2D risk (OR = 0.89, p = 0.010); both magnesium (OR = 0.26, p = 0.013) and iron (OR = 0.71, p = 0.047) are negatively correlated with gout risk. In the sensitivity analysis, causal estimation is not affected by pleiotropy. This study supports the long-standing hypothesis that magnesium supplementation can increase RA and BD risks and decrease OP risk and that copper intake can reduce AD and BD risks. This study will be helpful to address some controversial debates on the relationships between minerals and chronic diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mineral Nutrition and the Risk of Chronic Diseases: A Mendelian Randomization Study

2019

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“…Our results show higher levels of Zn in IHD patients. Serum zinc levels have been shown to correlate with intake of various medications as well as nutritional status, as it has an indirect absorption relationship with copper in IHD patients 26,27 . Manganese is part of superoxide dismutase and adenylyl cyclase, the two antioxidant enzymes fighting oxidative stress in the body.…”

Section: Discussionmentioning

confidence: 99%

“…Zinc acts as an antioxidant 23 and its deficiency has been linked to lipid peroxidation 24 as well as contractile dysfunction in the heart 25 . Other studies have hinted at the possibility that zinc may increase the risk of IHD 26 . Our results show higher levels of Zn in IHD patients.…”

Section: Discussionmentioning

confidence: 99%

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Understanding of metals dysregulation in patients with systolic and diastolic dysfunction in ischemic heart disease

Khan

Hashmi

Siddiqui

et al. 2020

Sci Rep

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ischemic heart disease (iHD) is the leading cause of death and chronic disability in the world. iHD affects both the systolic and diastolic function of the heart which progressively leads to heart failure; a structural and functional impairment of filling or ejection of blood from the heart. In this study, the progression of systolic and diastolic dysfunction characterized according to their echocardiographic parameters including left ventricular ejection fraction (EF), grades of diastolic dysfunction and ratio between early mitral inflow velocity and mitral annular early diastolic velocity (E/eʹ), were correlated with differential regulation of various metals in patients sera samples (n = 62) using inductive coupled plasma-mass spectrometry (ICP-MS). Chromium, nickel and selenium were found significant (p < 0.05) in patients having EF < 45% compared with EF > 45%. In patients with systolic dysfunction (EF < 45%), the level of selenium was decreased while the level of chromium and nickel was increased compared to patients with EF > 45%. Selenium level was also decreased significantly (p < 0.05) in grade 1A and 2 patients that are considered as higher grades of diastole dysfunction in comparison to grade 0-1. Overall, selenium deficiency was identified in both systolic and diastolic dysfunctions of IHD patients corresponding to the progression of disease that could be related to many metabolic and translational pathways specifically which involve selenoproteins. Cardiovascular diseases (CVDs) are the leading cause of death worldwide 1. An estimated 17.9 million people died from CVDs in 2015, representing 31% of all global deaths. Ischemic heart disease (IHD) account for the majority of the cases of health lost to CVDs. There are large number of prevalent cases of IHD making it the leading cause of chronic disability 1,2. The most common cause of IHD is atherosclerosis which is a chronic inflammatory process represented by highly specific cellular and molecular responses 3. IHD affects both the systolic and diastolic function of the heart which progressively leads to heart failure; a structural and functional impairment of filling or ejection of blood from the heart 4. Despite advances in the current treatment plans, heart failure remains one of the major health care issues of the world not only due to its increasing prevalence but also health care costs 5 .

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Nuts

Mohammed¹,

Qoronfleh²

2020

Advances in Neurobiology

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Effects of copper and zinc on ischemic heart disease and myocardial infarction: a Mendelian randomization study

Abstract: Genetic validation of a long-standing hypothesis suggests that further investigation of the effects, particularly of copper, on IHD may provide a practical means of reducing the leading cause of mortality and morbidity.

Cited by 35 publications

References 33 publications

Mineral Nutrition and the Risk of Chronic Diseases: A Mendelian Randomization Study

Mineral Nutrition and the Risk of Chronic Diseases: A Mendelian Randomization Study

Understanding of metals dysregulation in patients with systolic and diastolic dysfunction in ischemic heart disease

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