Effects of Convulsive Electroshock on Serum Concentrations of Follicle Stimulating Hormone, Luteinizing Hormone, Thyroid Stimulating Hormone and Growth Hormone in Man

Ryan, Robert J.; Swanson, David W.; Faiman, Charles; Mayberry, William E.; Spadoni, A.

doi:10.1210/jcem-30-1-51

Cited by 37 publications

(11 citation statements)

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“…The difference between our results and the findings of other authors (10,11,17) should be ascribed to the use of anticonvulsives in their observations. In rats, McCann et al (6) have found an inhibition of the secretion of several anterior pituitary hormones by Nembutal, probably as a consequence of blocking the transfer of stimuli to the regulating centers of the hypothalamus.…”

Section: Discussioncontrasting

confidence: 99%

“…Increase of serum HGH was found after surgery, exercise (3) and pyrogens (5), or even saline administration (12). It was therefore hardly understandable that such an intensive stimulus as the application of electric current during electroconvulsive therapy (ECT) was not followed by a rise of serum HGH (10,11,17). However, these observations were performed after anticonvulsive premedication which could have modified HGH response.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Electroconvulsive Therapy without Anticonvulsive Premedication on Serum Growth Hormone in Man

Vigaŝ¹,

Stowasserová²,

Németh³

et al. 1975

Horm Res

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Serum concentrations of human growth hormone (HGH) were measured in psychiatric patients during the first, third and sixth electroconvulsive therapy (ECT) without anticonvulsive premedication. Serum HGH increased 30 min after the application of current and no differences were found between responses to 1st, 3rd or 6th ECT. Maximal increase of serum glucose was seen after the first ECT and gradual decreases after the 3rd and 6th ECT were observed.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Electroconvulsive Therapy without Anticonvulsive Premedication on Serum Growth Hormone in Man

Vigaŝ¹,

Stowasserová²,

Németh³

et al. 1975

Horm Res

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“…Other stimuli such as electroshock [34], methimazole, methimazole-iodide, vasopressin, and glucagon have been equally unsuccessful [35]. The advent of supplies of natural and synthetic TSH releasing factor for clinical use has for the first time provided a means for rapid assessment of the pituitary TSH reserve in children [5].…”

Section: Discussionmentioning

confidence: 99%

Thyrotropin Behavior in Thyroid Disorders of Childhood

1973

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Through the use of a double antibody radioimmunoassay method, the mean serum concentration of thyrotropin (TSH) in 51 normal children aged 1 month-18 years was 3.7 ng/ml. There was no change with age, sex, or time of the day at which the sample was obtained.In six of nine newly diagnosed hyperthyroid children concentrations of TSH fell below the limit of detection, whereas in the remaining three concentrations were in the low normal range. Knowledge of the TSH fluctuations during medical treatment (antithyroid drugs or radioactive iodine plus 127 I) were useful in insuring a smooth clinical course. Elevations in TSH above 10 ng/ml served to indicate a need for change in therapy. Radical subtotal thyroidectomy evoked an acute compensatory rise (> 20 ng/ml) in TSH levels which was sometimes sufficient to maintain the level of serum thyroxine above 4 ^ig/100 ml. Hemithyroidectomy did not influence TSH or other thyroid parameters in previously euthyroid subjects.There was a clear separation between normal subjects and patients with primary hypothyroidism with values for TSH always exceeding 20 ng/ml in the latter. The TSH levels were below 3.7 ng/ml in pituitary hypothyroidism. In hypothyroid patients receiving adequate replacement therapy, elevations of serum TSH of > 20 ng/ml were encountered 2 weeks after discontinuation of treatment.Investigation of the pituitary-thyroidal axis in two untreated cretinous infants showed preservation of the functional integrity of the pituitary-thyroidal feedback system despite prenatal thyroid insufficiency as evidenced by a fall of TSH from levels >80 to <5 ng/ml in the presence of free thyroxine (FT 4 ) levels >2 ng/100 ml.In three patients (two females and one male) with longstanding juvenile hypothyroidism and TSH levels >80 ng/ml, pituitary dysfunctions characterized by luteinizing hormone (LH) concentrations above 20 mlU/ml and blunted growth hormone (HGH) responses to hypoglycemia were documented prior to therapy. Only the male had evidence of sexual precocity on physical examination. All three showed an abnormal circadian rhythm of cortisol secretion manifested by 8 PM values greater than 10 jug/100 ml. Acute restoration of euthyroidism in the two girls by means of parenteral thyroxine (T 4 ) improved the HGH response and normalized the cortisol rhythms in 72 hr, coincident with a sharp decline in TSH levels toward normal. In contrast, the high levels of LH declined much more slowly, failing to reach normal for as long as 7 weeks posttreatment.TSH in company with T 4 measurements permitted segregation of patients with Hashimoto's thyroiditis into three groups: (a) euthyroid with normal TSH and T 4 , 28Thyrotropin behavior in childhood thyroid disorders 29 (b) compensated with TSH values ranging between 19 and 28 ng/ml and T 4 in the 6-8 /zg/100 ml range, and (c) hypothyroid with T 4 below 3 ^g/100 ml and TSH values greater than 40 ng/ml. Speculation

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“…Experimental studies in humans given electroshock or experiencing spontaneous tonic-clonic and partial seizures have shown marked changes in output of pituitary hormones (Ryan et al, 1970;Vigas et al, 1975;Ohman et al, 1976;Trimble, 1978;Pritchard, 1980;Herzog et al, 1982;Aminoff et al, 1984). Experimental studies in humans given electroshock or experiencing spontaneous tonic-clonic and partial seizures have shown marked changes in output of pituitary hormones (Ryan et al, 1970;Vigas et al, 1975;Ohman et al, 1976;Trimble, 1978;Pritchard, 1980;Herzog et al, 1982;Aminoff et al, 1984).…”

Section: R H Mattson a N D J A Cramermentioning

confidence: 99%

Epilepsy, Sex Hormones, and Antiepileptic Drugs

1985

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Many factors associated with hormone function have an impact on the course of epilepsy. Patients with epilepsy may have disturbances in sexual function such as anovulatory cycles in women and decreased libido and potency in men. Data indicate seizures, especially those arising in the limbic system, may influence the hypothalamic pituitary axis. Antiepileptic drugs also influence sexual function through direct brain effects as well as through induced changes in pharmacokinetics of the sex steroid hormones. Pregnancy has been reported to be a time of increased seizures; however, this has often been associated with low drug levels, for reasons that include inadequate drug dose, possible changes in pharmacokinetics, and noncompliance. Some evidence suggests that hormones affect seizure frequency. Changes in seizures during the menstrual cycle (catamenial epilepsy) have been found in some women: seizures were fewer during the luteal phase but increased when progesterone levels declined. Some improvement in seizure frequency has been shown in pilot studies using medroxyprogesterone acetate, a synthetic progesterone. Current concepts of the interrelationship among epilepsy, sex hormones, and antiepileptic drugs are discussed.

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Effects of Convulsive Electroshock on Serum Concentrations of Follicle Stimulating Hormone, Luteinizing Hormone, Thyroid Stimulating Hormone and Growth Hormone in Man

Cited by 37 publications

References 1 publication

Effect of Electroconvulsive Therapy without Anticonvulsive Premedication on Serum Growth Hormone in Man

Effect of Electroconvulsive Therapy without Anticonvulsive Premedication on Serum Growth Hormone in Man

Thyrotropin Behavior in Thyroid Disorders of Childhood

Epilepsy, Sex Hormones, and Antiepileptic Drugs

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