Effects of conventionally treated and ozonated wastewater on the damselfly larva oxylipidome in response to on-site exposure

Späth, Jana; Brodin, Tomas; Falås, Per; Niinipuu, Mirva; Lindberg, Richard H.; Fick, Jerker; Nording, Malin L.

doi:10.1016/j.chemosphere.2022.136604

Cited by 2 publications

(1 citation statement)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another advantage of RNA-Seq is that it allows for the design of ecologically relevant experiments, such as those investigating the toxicity of APIs in the context of additional stressors like climate change (Almeida et al, 2018) or with transplanted organisms to assess their plasticity when exposed to different pollution sources (Rivetti et al, 2015). By using these experimental approaches, alongside DNA-and RNAbased methods, we can bridge the knowledge gap regarding the real-world impacts of API mixtures and gain insights into the linkages between molecular initiating events and adverse outcomes, which can range from cellular to population-level effects in nontarget organisms (Ankley et al, 2010(Ankley et al, , 2024Späth et al, 2022).…”

Section: Molecular Approaches For Assessing Mixtures Of Pharmaceuticalsmentioning

confidence: 99%

Environmental Risks of Pharmaceutical Mixtures in Aquatic Ecosystems: Reflections on a Decade of Research

Kidd,

Backhaus,

Brodin

et al. 2023

Enviro Toxic and Chemistry

Self Cite

View full text Add to dashboard Cite

Pharmaceuticals and personal care products (PPCPs) occur as variable mixtures in surface waters receiving discharges of human and animal wastes. A key question identified a decade ago is how to assess the effects of long‐term exposures of these PPCP mixtures on non‐target organisms? Herein we review the recent progress made on assessing the aquatic ecotoxicity of PPCP mixtures ‐ with a focus on active pharmaceutical ingredients (APIs) ‐ and the challenges and research needs that remain. New knowledge has arisen from the use of whole mixture testing combined with components‐based approaches, and these studies show that mixtures often result in responses that meet the concentration addition model. However, such studies have mainly been done on individual species over shorter time periods, and longer‐term, multispecies assessments remain limited. The recent use of targeted and non‐targeted gene analysis has improved our understanding of the diverse pathways that are impacted, and there are promising new “read‐across” methods that use mammalian data to predict toxicity in wildlife. Risk assessments remain challenging given the paucity of ecotoxicological and exposure data on PPCP mixtures. As such, the assessment of PPCP mixtures in aquatic environments should remain a priority given the potential for additive ‐ as well as non‐target ‐ effects in non‐target organisms. In addition, we need to improve our understanding of which species, lifestages and relevant endpoints are most sensitive to which type of PPCP mixture, and to expand our knowledge of environmental PPCP levels in regions of the globe that have been poorly studied to date. We recommend an increased use of New Approach Methodologies, in particular ‘Omics’, to advance our understanding of the molecular mechanics of mixture effects. Finally, we call for systematic research on the role of PPCP mixtures in the development of antimicrobial resistance.

show abstract

Section: Molecular Approaches For Assessing Mixtures Of Pharmaceuticalsmentioning

confidence: 99%

Environmental Risks of Pharmaceutical Mixtures in Aquatic Ecosystems: Reflections on a Decade of Research

Kidd,

Backhaus,

Brodin

et al. 2023

Enviro Toxic and Chemistry

Self Cite

View full text Add to dashboard Cite

show abstract

Uncovering the mesoporous secrets of Ti/γAl2O3 3-D gels: Fine-tuning morphology engineering for enhancing catalytic ozonation efficacy of environmental contaminants

Ostovar,

Moussavi,

Mohammadi

et al. 2024

Separation and Purification Technology

View full text Add to dashboard Cite

Effects of conventionally treated and ozonated wastewater on the damselfly larva oxylipidome in response to on-site exposure

Cited by 2 publications

References 47 publications

Environmental Risks of Pharmaceutical Mixtures in Aquatic Ecosystems: Reflections on a Decade of Research

Environmental Risks of Pharmaceutical Mixtures in Aquatic Ecosystems: Reflections on a Decade of Research

Uncovering the mesoporous secrets of Ti/γAl2O3 3-D gels: Fine-tuning morphology engineering for enhancing catalytic ozonation efficacy of environmental contaminants

Contact Info

Product

Resources

About