“…Severe spinal cord injury (SCI) causes long-term consequences, similar to the traumatic brain injury (TBI). The consequences include cognitive decline and depression-like behavior, known to accompany neurodegenerative processes in CNS ( Davidoff et al, 1992 ; Verweij et al, 1997 ; Robertson, 2004 ; Wu and Bogie, 2014 ; Wu et al, 2016 ; Jure and Labombarda, 2017 ). Neuroinflammation may link the CNS injuries to mental perturbations, as all these phenomena are involved with microglia activation ( Chitnis and Weiner, 2017 ; Baufeld et al, 2018 ; Kinney et al, 2018 ; Pavlov et al, 2020 ) and dysregulation of cytokines ( Allison and Ditor, 2015 ; Maldonado-Bouchard et al, 2016 ; do Espirito Santo et al, 2019 ; Wadhawan et al, 2019 ).…”