Effects of contrast agents on relaxation properties of <sup>31</sup>P metabolites

Valkovič, Ladislav; Lau, Justin Y. C.; Abdesselam, Inès; Rider, Oliver J; Frollo, Ivan; Tyler, Damian J.; Rodgers, Christopher T.; Miller, Jack J.

doi:10.1002/mrm.28541

Cited by 1 publication

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References 34 publications

(59 reference statements)

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“…The addition of PRE agents has been previously used to accelerate NMR data acquisition [ 13 , 17 , 22 , 23 , 24 , 25 ]. PRE agents contain unpaired electrons and decrease T 1 relaxation times for all nuclei in a sample due to dipolar interactions between nuclear and electron spin states.…”

Section: Resultsmentioning

confidence: 99%

Gadolinium-Based Paramagnetic Relaxation Enhancement Agent Enhances Sensitivity for NUS Multidimensional NMR-Based Metabolomics

Honrao¹,

Teissier²,

Zhang³

et al. 2021

Molecules

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Gadolinium is a paramagnetic relaxation enhancement (PRE) agent that accelerates the relaxation of metabolite nuclei. In this study, we noted the ability of gadolinium to improve the sensitivity of two-dimensional, non-uniform sampled NMR spectral data collected from metabolomics samples. In time-equivalent experiments, the addition of gadolinium increased the mean signal intensity measurement and the signal-to-noise ratio for metabolite resonances in both standard and plasma samples. Gadolinium led to highly linear intensity measurements that correlated with metabolite concentrations. In the presence of gadolinium, we were able to detect a broad array of metabolites with a lower limit of detection and quantification in the low micromolar range. We also observed an increase in the repeatability of intensity measurements upon the addition of gadolinium. The results of this study suggest that the addition of a gadolinium-based PRE agent to metabolite samples can improve NMR-based metabolomics.

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Section: Resultsmentioning

confidence: 99%

Gadolinium-Based Paramagnetic Relaxation Enhancement Agent Enhances Sensitivity for NUS Multidimensional NMR-Based Metabolomics

Honrao¹,

Teissier²,

Zhang³

et al. 2021

Molecules

View full text Add to dashboard Cite

show abstract

Effects of contrast agents on relaxation properties of ³¹P metabolites

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 1 publication

References 34 publications

Gadolinium-Based Paramagnetic Relaxation Enhancement Agent Enhances Sensitivity for NUS Multidimensional NMR-Based Metabolomics

Gadolinium-Based Paramagnetic Relaxation Enhancement Agent Enhances Sensitivity for NUS Multidimensional NMR-Based Metabolomics

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Effects of contrast agents on relaxation properties of 31P metabolites

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 1 publication

References 34 publications

Gadolinium-Based Paramagnetic Relaxation Enhancement Agent Enhances Sensitivity for NUS Multidimensional NMR-Based Metabolomics

Gadolinium-Based Paramagnetic Relaxation Enhancement Agent Enhances Sensitivity for NUS Multidimensional NMR-Based Metabolomics

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Effects of contrast agents on relaxation properties of ³¹P metabolites