Effects of Continuous Positive Airway Pressure on Renal Function in Prematures

Tulassay, T; Machay, T; Kiszel, J; Varga, József

doi:10.1159/000241622

Cited by 25 publications

(3 citation statements)

References 20 publications

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“…In contrast, in our study pretreatment urine output was higher in the furosemide group. Because the control group received more surfactant therapy than the furosemide group, this might indicate that the control group suffered from more severely respiratory distress and hence negative effects on renal function resulting from decreased venous return and low cardiac output and high vasopressin levels (16). The necessity to increase urine output in our subjects of the furosemide group with higher baseline urine output is probably less.…”

Section: Discussionmentioning

confidence: 99%

Furosemide in preterm infants treated with indomethacin for patent ductus arteriosus

et al. 2009

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Section: Discussionmentioning

confidence: 99%

Furosemide in preterm infants treated with indomethacin for patent ductus arteriosus

et al. 2009

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“…Ventilation of human neonates and newborn animals with continuous positive airway pressure has deleterious effects on renal function due to decreased venous return and low cardiac output, increased renal sympathetic nervous activity, and high serum vasopressin levels [47,48] ( Fig. 1).…”

Section: Ventilationmentioning

confidence: 99%

The stressed neonatal kidney: from pathophysiology to clinical management of neonatal vasomotor nephropathy

Tóth-Heyn¹,

Drukker

Guignard

2000

Pediatric Nephrology

190

115

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The healthy term, and particularly the premature infant, is born with a very low glomerular filtration rate (GFR), controlled by a delicate balance of intrarenal vasoconstrictor and vasodilator forces. Vasoactive disturbances can easily further reduce the already low GFR. The newborn infant is thus prone to develop vasomotor nephropathy (VMNP) or acute renal failure (ARF). The main causes for ARF at this young age are prerenal mechanisms, and include hypotension, hypovolemia, hypoxemia perinatal asphyxia, and neonatal septicemia. Other causes include the administration of angiotensin converting enzyme inhibitors, indomethacin and tolazoline. The most-important factors governing the ultimate renal prognosis are the severity of the underlying disorder, the rapidity of an accurate diagnosis, prompt treatment, and avoidance of severe iatrogenic complications. The immediate treatment is of particular importance in VMNP, i.e., prerenal ischemic ARF, and consists of correcting abnormalities in fluid homeostasis and reduction of the complications of the acute azotemic state (uremia, hyperkalemia, acidosis, and hypertension). In severe and prolonged (established) ARF, temporary dialysis therapy may be indicated. Prerenal ARF with oliguria or anuria warrants immediate volume resuscitation. Special attention should be given to infants with congestive heart failure (CHF). The sick neonate with persistent oliguria and CHF should be treated with intravenous dopamine. Furosemide (FM) is the second line of therapy for babies with indomethacin-induced ARF. In most other conditions, the therapeutic effect of FM is limited to a transient increase in urine flow, without improving basic renal function. The special conditions of the maturing kidney have to be appreciated in order to protect babies from undue renal injury. With the increasing knowledge of the mechanisms governing the development of ARF, progress has been made in the development of new treatment modalities. For example theophylline, calcium antagonists, ATP-MgCl2, thyroxine, and a variety of cytokines may in the near future be used to prevent or ameliorate VMNP and/or recently established ARF. With a combination of time-honored and new therapeutic strategies, there may well be a brighter future for neonates with vasomotor, prerenal, ischemic ARF.

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“…19 Influences of renal function under NCPAP support have been documented, such as diminished urinary output, reduced urinary sodium excretion, and decreased glomerular filtration rate. 20 However, complications from NCPAP have become more evident as gastric distention, nasal bridge lesions, and patient discomfort due to head-securing devices have been documented. Furthermore, a well-trained nurse is needed in the intensive care setting to perform routine care.…”

Section: Mechanism Of Ncpapmentioning

confidence: 99%

The Role of Heated Humidified High-flow Nasal Cannula as Noninvasive Respiratory Support in Neonates

Chao

Tsai

Chien³

et al. 2017

Pediatrics & Neonatology

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Recently, heated humidified high-flow nasal cannula (HHHFNC) has been introduced and applied as a noninvasive respiratory support in neonates. Although HHHFNC is widely used in neonates presenting with respiratory distress, the efficiency and safety when compared with nasal continuous positive airway pressure or noninvasive positive pressure ventilation are still controversial. This review aims to evaluate the performance and applications of HHHFNC in neonates.

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Effects of Continuous Positive Airway Pressure on Renal Function in Prematures

Cited by 25 publications

References 20 publications

Furosemide in preterm infants treated with indomethacin for patent ductus arteriosus

Furosemide in preterm infants treated with indomethacin for patent ductus arteriosus

The stressed neonatal kidney: from pathophysiology to clinical management of neonatal vasomotor nephropathy

The Role of Heated Humidified High-flow Nasal Cannula as Noninvasive Respiratory Support in Neonates

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