Effects of Continuous Ingestion of Hesperidin and Glucosyl Hesperidin on Vascular Gene Expression in Spontaneously Hypertensive Rats

Yamamoto, Masaki; Jokura, Hiroko; Suzuki, Atsushi; Hase, Tadashi; Shimotoyodome, Akira

doi:10.3177/jnsv.59.470

Cited by 34 publications

(13 citation statements)

References 23 publications

(13 reference statements)

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“…FFA also seem to play a possible important role in hypertension development in patient with obesity and MetS [41]. In agreement with our results, the antihypertensive effects of hesperidin have been previously described in spontaneously hypertensive rats [44,45] and, recently, in rats that were fed a high-fat, high-sucrose diet [28]. Interestingly, SBP reduction in CAF-H2 rats was accompanied by an increase in insulin sensitivity and a reduction in FFA.…”

Section: Discussionsupporting

confidence: 91%

Metabolomics Elucidates Dose-Dependent Molecular Beneficial Effects of Hesperidin Supplementation in Rats Fed an Obesogenic Diet

et al. 2020

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Metabolic syndrome (MetS) is a global epidemic concern. Polyphenols are proposed as good candidates for its prevention, although their mechanisms are not fully understood. The gut microbiota seems to play a key role in polyphenol beneficial effects. Here, we assessed the effects of the citrus polyphenol hesperidin combining an untargeted metabolomics approach, which has an inherent potential to elucidate the host-microbiome interplay, with extensive anthropometric and biochemical characterizations and integrating metabolomics results with our previous 16S rRNA bacterial sequencing data. The rats were fed either a standard or an obesogenic cafeteria diet (CAF) for 17 weeks. After nine weeks, rats were supplemented with vehicle; low- (H1), or high- (H2) hesperidin doses. CAF animals developed MetS features. Hesperidin supplementation in CAF rats decreased the total cholesterol, LDL-C, and free fatty acids. The highest hesperidin dose also ameliorated blood pressure, insulin sensitivity, and decreased markers of arterial stiffness and inflammation. Metabolomics revealed an improvement of the lipidomic profile, decreases in circulating amino acids, and lower excretions of inflammation- and oxidative stress-related metabolites. Bacteroidaceae increases in the CAF-H2 group paralleled higher excretions of microbial-derived metabolites. Overall, our results provide detailed insights into the molecular effects of hesperidin on MetS and suggest that it is a promising prebiotic for the treatment of MetS and related conditions.

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Section: Discussionsupporting

confidence: 91%

Metabolomics Elucidates Dose-Dependent Molecular Beneficial Effects of Hesperidin Supplementation in Rats Fed an Obesogenic Diet

et al. 2020

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“…The hesperetin metabolites, rather than the parent flavanones or hesperetin aglycone, in the circulatory system may give rise to some of the biological activity observed after consumption of oranges. Orally administered hesperidin suppressed mRNA of NADPH‐oxidase in spontaneously hypertensive rats and importantly hesperetin‐7‐ O ‐glucuronide, but not the 3′‐ O ‐glucuronide, given intravenously decreased blood pressure in the same type of spontaneously hypertensive rats . Furthermore, hesperetin‐3′‐ O ‐sulfate and hesperetin‐3′‐ O ‐glucuronide at a concentration of 2 μmol/L inhibited gene activation and monocyte adhesion to TNF‐α‐activated human umbilical vein endothelial cells.…”

Section: Discussionmentioning

confidence: 94%

Gastrointestinal absorption and metabolism of hesperetin‐7‐O‐rutinoside and hesperetin‐7‐O‐glucoside in healthy humans

Actis‐Goretta

Dew

Lévêques

et al. 2015

Molecular Nutrition Food Res

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“…Vasoactive properties of the main flavonoids of the Citrus genus, naringenin and hesperetin, have been widely described; particularly, Rizza et al demonstrated that hesperetin induces vasodilatation through endothelial production of nitric oxide (NO) and its derivative, glycosyl-hesperidin, which was administered for 8 weeks to spontaneously hypertensive rats, was able to reduce pressure parameters 3% in addition to improving the endothelial response [25,58,59,60]. Moreover, on isolated coronary arteries of rodents, hesperetin caused vasodilatation by activating voltage-operated calcium channels and potassium currents [61].…”

Section: Putative Mechanisms Of Action Responsible For the Cardiovmentioning

confidence: 99%

Nutraceutical Value of Citrus Flavanones and Their Implications in Cardiovascular Disease

2017

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Background- Cardiovascular diseases, including myocardial infarction, dyslipidaemia and coronary artery pathology, are a major cause of illness and death in Western countries. Therefore, identifying effective therapeutic approaches and their cellular signalling pathways is a challenging goal for medicine. In this regard, several epidemiological studies demonstrate a relationship between the intake of flavonoid-rich foods and the reduction of cardiovascular risk factors and mortality. In particular, flavonoids present in citrus fruits, such as oranges, bergamots, lemons and grapefruit (95% from flavanones), are emerging for their considerable nutraceutical value. Methods- In this review an examination of literature was performed while considering both epidemiological, clinical and pre-clinical evidence supporting the beneficial role of the flavanone class. We evaluated studies in which citrus fruit juices or single flavanone administration and cardiovascular risk factors were analysed; to identify these studies, an electronic search was conducted in PUBMED for papers fulfilling these criteria and written in English. Results- In addition to epidemiological evidence and clinical studies demonstrating that fruits in the Citrus genus significantly reduce the incidence of cardiovascular disease risk, pre-clinical investigations highlight cellular and subcellular targets that are responsible for these beneficial effects. There has been special attention on evaluating intracellular pathways involved in direct cardiovascular and cardiometabolic effects mediated by naringenin, hesperetin and eriodictyol or their glycosylated derivatives. Conclusions- Although some mechanisms of action remain unclear and bioavailability problems remain to be solved, the current evidence supports the use of a nutraceutical approach with citrus fruits to prevent and cure several aspects of cardiovascular disease.

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Effects of Continuous Ingestion of Hesperidin and Glucosyl Hesperidin on Vascular Gene Expression in Spontaneously Hypertensive Rats

Cited by 34 publications

References 23 publications

Metabolomics Elucidates Dose-Dependent Molecular Beneficial Effects of Hesperidin Supplementation in Rats Fed an Obesogenic Diet

Metabolomics Elucidates Dose-Dependent Molecular Beneficial Effects of Hesperidin Supplementation in Rats Fed an Obesogenic Diet

Gastrointestinal absorption and metabolism of hesperetin‐7‐O‐rutinoside and hesperetin‐7‐O‐glucoside in healthy humans

Nutraceutical Value of Citrus Flavanones and Their Implications in Cardiovascular Disease

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