Effects of Continuous In Utero Low- and Medium-Dose-Rate Gamma-Ray Exposure on Fetal Germ Cells

Nakahira, Rei; Ayabe, Yoshiko; Braga-Tanaka, Ignacia; Tanaka, Satoshi; Komura, Jun‐ichiro

doi:10.1667/rade-20-00093.1

Cited by 6 publications

(4 citation statements)

References 56 publications

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“…In mammalian fetal testes, germ cells are cells with the greatest sensitivity to ionizing radiation (RAD) [3,42,43]. Doses as low as 0.1 Gy during germ cell proliferation cause DNA double strand breaks (DSBs) and induces cell death by apoptosis [3].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have demonstrated the negative impact of postnatal irradiation at doses higher than 1 Gy on human and rodent Leydig cells and androgen production [8,9,[11][12][13][14]. To our knowledge, very few studies have examined the long-term effect of testicular exposure to radiation in utero on adult Leydig cells [43,[67][68][69], and most of these studies have reported no obvious effect. In this study, we provide the first evidence that fetal exposure to radiation has an endocrine disrupting effect independent of direct action on estrogen and androgen receptors.…”

Section: Discussionmentioning

confidence: 99%

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Unexpected Interacting Effects of Physical (Radiation) and Chemical (Bisphenol A) Treatments on Male Reproductive Functions in Mice

Wieckowski

Ranga

Moison

et al. 2021

IJMS

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For decades, numerous chemical pollutants have been described to interfere with endogenous hormone metabolism/signaling altering reproductive functions. Among these endocrine disrupting substances, Bisphenol A (BPA), a widely used compound, is known to negatively impact germ and somatic cells in the testis. Physical agents, such as ionizing radiation, were also described to perturb spermatogenesis. Despite the fact that we are constantly exposed to numerous environmental chemical and physical compounds, very few studies explore the impact of combined exposure to chemical and physical pollutants on reproductive health. The aim of this study was to describe the impact of fetal co-exposure to BPA and IR on testicular function in mice. We exposed pregnant mice to 10 µM BPA (corresponding to 0.5 mg/kg/day) in drinking water from 10.5 dpc until birth, and we irradiated mice with 0.2 Gy (γ-ray, RAD) at 12.5 days post-conception. Co-exposure to BPA and γ-ray induces DNA damage in fetal germ cells in an additive manner, leading to a long-lasting decrease in germ cell abundance. We also observed significant alteration of adult steroidogenesis by RAD exposure independently of the BPA exposure. This is illustrated by the downregulation of steroidogenic genes and the decrease of the number of adult Leydig cells. As a consequence, courtship behavior is modified, and male ultrasonic vocalizations associated with courtship decreased. In conclusion, this study provides evidence for the importance of broadening the concept of endocrine disruptors to include physical agents, leading to a reevaluation of risk management and regulatory decisions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Unexpected Interacting Effects of Physical (Radiation) and Chemical (Bisphenol A) Treatments on Male Reproductive Functions in Mice

Wieckowski

Ranga

Moison

et al. 2021

IJMS

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“…Cells that divide rapidly are more vulnerable to radiation than those cells that divide at a slower rate. The germ cells supporting the growth and maturation of the oocytes are more radiosensitive than the stromal cells that give structural support to the ovary [32].…”

Section: Factors Affecting Ovarian Radiosensitivitymentioning

confidence: 99%

Radiation-induced premature ovarian failure: focus on the role of ovarian inflammatory signaling pathways.

Mohamed,

Mantawy,

Said

et al. 2023

Archives of Pharmaceutical Sciences Ain Shams University

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Radiation therapy, an effective treatment modality for many types of cancer, often carries a heavy cost for young women. In particular, those undergoing pelvic radiotherapy mostly experience sudden menopausal symptoms and premature ovarian failure (POF) impacting their reproductive health and overall quality of life. Upon radiation, excessive reactive oxygen species (ROS) are produced causing a state of oxidative stress to tissues. Following this, DNA is damaged augmenting subsequent inflammatory responses and further tissue damage. Mild inflammation is essential for the development and release of oocytes. However, prolonged inflammation is associated with poor quality oocytes and sometimes complete dysfunction of the ovaries, as excessively produced pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF-α) and interleukins (IL) lead to compromised ovary functionality. This work aims at considering the radiation-induced POF as an inflammatory process. It also covers key molecular pathways involved in this response like nuclear factor kappa-B (NF-κB), transforming growth factor-β (TGF-β), mitogen-activated protein kinase (MAPK), sirtuin-1 (SIRT-1), poly [ADP-ribose] polymerase-1 (PARP-1) and insulin-like growth factor-1 (IGF-1) in regulating inflammation. Eventually, understanding these interrelated pathways can provide researchers with valuable molecular targets that can be used to develop new protective agents for radiation-induced POF thus improving the quality of life for these patients.

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“…Similar studies of the effects of chronic irradiation on animals were carried out after the nuclear accident at the Chernobyl nuclear power plant [8,9,10,11,12,13]. Most of the mentioned studies were aimed at assessing the general physiological, environmental and population parameters of animals [14,15]. However, the question still remains of assessing the effect of radiation on reproductive organs, gametes and the development of embryos.…”

Section: Introductionmentioning

confidence: 99%

In vitro development of preimplantation cattle embryos obtained from oocytes irradiated with low doses of ionizing radiation

Vazirov,

Makutina,

Krivonogova

et al. 2024

BIO Web Conf.

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Radiation-induced processes in germ reproductive cells, as well as the effect of low doses of radiation on the reproductive potential of farm animals remain poorly studied. Assessing the radiation effects of low doses on gametes and early embryos will reveal biological features that are important for assisted reproductive technologies in animal husbandry. In addition, the study of the processes of maturation and fertilization of irradiated gametes and the subsequent development of early preimplantation embryos will make it possible to update measures to protect the health and reproductive potential of farm animals in conditions of technogenic radiation risks. In this study, we focused on analyzing the effects of irradiation on the ovaries of cattle and examining the consequences of this exposure on embryo development under in vitro fertilization conditions. We used X-ray radiation of different dose rates with an absorbed dose of 100 mGy. The research results showed a decrease in the frequency of blastocyst formation in all experimental groups of embryos obtained from oocytes of irradiated ovaries. The data obtained can serve as a scientific basis for the development of measures to preserve the reproductive potential of farm animals under technogenic radiation risks, as well as for further search of ways to improve assisted reproductive technologies in animal husbandry.

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Effects of Continuous In Utero Low- and Medium-Dose-Rate Gamma-Ray Exposure on Fetal Germ Cells

Abstract: BioOne Complete (complete.BioOne.org) is a full-text database of 200 subscribed and open-access titles in the biological, ecological, and environmental sciences published by nonprofit societies, associations, museums, institutions, and presses.

Cited by 6 publications

References 56 publications

Unexpected Interacting Effects of Physical (Radiation) and Chemical (Bisphenol A) Treatments on Male Reproductive Functions in Mice

Unexpected Interacting Effects of Physical (Radiation) and Chemical (Bisphenol A) Treatments on Male Reproductive Functions in Mice

Radiation-induced premature ovarian failure: focus on the role of ovarian inflammatory signaling pathways.

In vitro development of preimplantation cattle embryos obtained from oocytes irradiated with low doses of ionizing radiation

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