Effects of conjugated linoleic acid on oxidative stress in rats with sucrose-induced non-alcoholic fatty liver disease

Romero-Sarmiento, Yohevet; Soto-Rodríguez, Ida; Arzaba-Villalba, Agustín; Garcı́a, Hugo S.; Alexander‐Aguilera, Alfonso

doi:10.1016/j.jff.2011.10.009

Cited by 19 publications

(11 citation statements)

References 32 publications

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“…Activation of Nrf2 also induces glyoxalase-1 expression, which promotes MG to form d -lactic acid [ 9 ]. A prior study has reported an association between oxidative stress and cell damage [ 10 ]. However, a higher level of MG (200 ppm) was found in patients with diabetes compared to people without diabetes (5 ppm) [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo

Cheng¹,

Chen

Lee³

et al. 2015

Nutrients

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Methylglyoxal (MG) has been found to cause inflammation and insulin resistance in vitro and in vivo in recent studies. Resveratrol has been proposed as an effective treatment that helps lower the risk of developing complications of diabetes. To study the significance of glycosylation-related stress on the pathology of diabetes, the effects of resveratrol were examined in a mouse model of diabetes induced by MG. Resveratrol was given via oral gavage in MG-treated mice, and diabetes-related tests and markers were assessed using biochemical and immunohistochemical analyses. Treatment with resveratrol markedly improved blood glucose level from the oral glucose tolerance test and promoted nuclear factor erythroid 2-related factor-2 (Nrf2) phosphorylation (p < 0.05) in the pancreas of MG-treated mice. However, these effects were abolished by retinoic acid, Nrf2 inhibitor, in resveratrol and retinoic acid-treated and MG-induced mice. These findings support that resveratrol may be useful in the treatment of type-2 diabetes by protecting against pancreatic cell dysfunction.

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Section: Introductionmentioning

confidence: 99%

Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo

Cheng¹,

Chen

Lee³

et al. 2015

Nutrients

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“…However, there are discrepancies found about the effect of CLA on the integrity of the hepatocyte, since it has been reported that its consumption causes hepatotoxicity. [50] Conversely, there are studies in which CLA administration did not modify [51] or decrease [52] transaminases activities. It is important to note that the isomer associated with hepatotoxicity is t10,c12-CLA [53] and in our work we used a mixture of the isomers c9,t11-CLA and t10,c12-CLA in similar proportions.…”

Section: Discussionmentioning

confidence: 99%

Conjugated Linoleic Acid Supplemented Diet Influences Serum Markers in Orchidectomized Sprague‐Dawley Rats

Rojas

Villalpando

Ferrer

et al. 2020

Euro J Lipid Sci & Tech

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Conjugated isomers of linoleic acid have beneficial effects on human health, with demonstrated anticarcinogenic, antiatherogenic, antioxidant, and anti‐inflammatory properties. Previous studies have shown that the loss of sex hormones induced by orchidectomy affects vascular function and serum lipids. The objective of this work is to evaluate the effect of conjugated linoleic acid (CLA) on serum lipids, cardiac, renal, and hepatic markers in orchidectomized Sprague‐Dawley rats. Male sex hormone deprivation is induced by orchidectomy to 24‐week‐old rats. The rats are fed a diet containing 1.8% w/w CLA, or a control diet for 8 weeks. At the end of the treatment, serum markers are measured using commercially available kits. The concentrations found in the orchidectomized‐CLA (ORX‐CLA) group of total cholesterol, low‐density lipoproteins (LDL), as well as the atherogenic index, concentrations of creatine kinase, lactate dehydrogenase, C‐reactive protein, glucose, urea, uric acid, creatinine, albumin, calcium, total protein, and bilirubin are significantly lower compared to the orchidectomized‐control (ORX‐C) group. The concentrations of high‐density lipoproteins (HDL), calcium, total protein, albumin, total bilirubin, and indirect bilirubin are significantly higher in the ORX‐CLA group than in the ORX‐C group. The CLA‐supplemented diet exerts a beneficial effect on different biochemical parameters negatively affected by orchidectomy, which may result in vascular protection. Practical Applications: The relationship between testosterone deficiency and the alteration of serum lipids is demonstrated; however, it is demonstrated in this study that the markers of renal damage, cardiac damage, and oxidative stress are also negatively affected by the lack of this hormone. This information has enriched the understanding about the relationship between testosterone deficiency and the development of different diseases such as metabolic syndrome, type 2 diabetes, kidney failure, osteoporosis, cardiovascular diseases, and cancer. On the other hand, CLA has been studied mainly as a nutraceutical and sports supplement; the information in this study will help to expand the knowledge about the benefits of these isomers of linoleic acid, providing guidelines for its use as a protection against negative effects triggered by orchidectomy.

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“…Others demonstrated that CLA supplementation did not change oxidized LDL, serum lipid peroxidation, or lipid antioxidant concentrations (Pfeuffer and others ; Kim and others ). In addition, dietary CLA showed a beneficial effect on the oxidative stress in liver of rats with nonalcoholic fatty liver disease (Romero‐Sarmiento and others ). Based on these, it was suggested that increased oxidative markers after CLA supplementation may not represent a potential health risk, rather this may be the results of metabolisms of CLA that may be detected as oxidative markers (Park ).…”

Section: Safety Consideration For Cla Usementioning

confidence: 97%

Conjugated Linoleic Acid and Postmenopausal Women's Health

Kim¹,

Kim²,

Park

2015

Journal of Food Science

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Declined estrogen levels in women after menopause can cause a number of significant health issues, and various estrogen receptor ligands have been clinically evaluated for postmenopausal treatment. Conjugated linoleic acid (CLA) has been shown to display protective effects against menopausal symptoms such as bone loss and metabolic dysfunctions in both animals and humans. In particular, it inhibits the proliferations of breast and endometrial cancer cells through estrogen receptor α-mediated mechanism(s). These findings suggest that CLA may provide beneficial effects on menopausal symptoms, while protecting the endometrium and breast from estrogen stimulation. Thus, understanding the effects of CLA on menopausal disorders and ER metabolism is important in development of novel therapeutic options for use in postmenopausal women with or without conventional estrogen therapy. In this report, we review literature regarding the impact of CLA on menopausal symptoms in cell lines, rodents, and humans, along with potential mechanism(s). We also discuss safety consideration for CLA use in humans.

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Effects of conjugated linoleic acid on oxidative stress in rats with sucrose-induced non-alcoholic fatty liver disease

Cited by 19 publications

References 32 publications

Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo

Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo

Conjugated Linoleic Acid Supplemented Diet Influences Serum Markers in Orchidectomized Sprague‐Dawley Rats

Conjugated Linoleic Acid and Postmenopausal Women's Health

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