Effects of Conjugated Linoleic Acid on Anaphylaxis and Allergic Pruritus.

Ishiguro, Kyoko; Oku, Hisae; Suitani, Akiko; Yamamoto, Yuta

doi:10.1248/bpb.25.1655

Cited by 27 publications

(22 citation statements)

References 22 publications

(24 reference statements)

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“…CLA-induced suppression of antibody-dependent inflammatory responses have also been demonstrated in the airway (51,52), where antigen-induced contraction of trachea (% of maximum contraction) was decreased when harvested from guinea pigs fed CLA. Anaphylaxis in response to egg white lysozyme was decreased by dietary CLA in mice (19). Longevity of NZB/W F1 mice that spontaneously develop lupus erythematosus was extended 1.5-fold if the mice were fed CLA compared with corn oil (55).…”

Section: Discussionmentioning

confidence: 98%

A mechanistic approach to understanding conjugated linoleic acid's role in inflammation using murine models of rheumatoid arthritis

Bütz¹,

Li²,

Huebner³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

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Section: Discussionmentioning

confidence: 98%

A mechanistic approach to understanding conjugated linoleic acid's role in inflammation using murine models of rheumatoid arthritis

Bütz¹,

Li²,

Huebner³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Intradermal injection of platelet-activating factor elicits itch in normal skin of humans (30,31) and elicits scratching in mice (32) but not in rats (33). It has been claimed to be an important mediator of ocular itching in guinea pigs (34).…”

Section: Discussionmentioning

confidence: 99%

Possible Involvement of 5-Lipoxygenase Metabolite in Itch-Associated Response of Mosquito Allergy in Mice

et al. 2007

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Abstract. This study investigated endogenous mediators involved in mosquito allergyassociated itching in mice. An intradermal injection of an extract of mosquito salivary gland elicited marked scratching in sensitized mice. The 5-lipoxygenase inhibitor zileuton (100 mg / kg), the 5-lipoxygenase activating peptide inhibitor MK-886 (10 mg / kg), and the glucocorticoid betamethasone 17-valerate (3 mg / kg) inhibited the scratching. The scratching was not affected by the cyclooxygenase inhibitors indomethacin and ketoprofen, the TP prostanoid receptor antagonist SQ-29548, the leukotriene B 4 antagonist ONO-4057, the cysteinyl leukotriene antagonist pranlucast, the leukotriene D 4 antagonist MK-571, the platelet-activating factor antagonist CV-3988, the nitric oxide synthase inhibitor N G -nitro-L-arginine methyl ester, the H 2 histamine-receptor antagonist cimetidine, the H 1 histamine-receptor antagonist terfenadine plus cimetidine, and cypoheptadine that blocks the 5-HT 1/ 2 serotonin receptors. Zileuton (100 mg / kg) inhibited the increased activity of the cutaneous nerve branch induced by an intradermal injection of the extract, suggesting the peripheral action. Zileuton and MK-886 (10 and 100 µM) did not affect high K + -induced increase in intracellular Ca 2+ concentration in cultured dorsal root ganglion neurons. The results suggest that 5-lipoxygenase metabolite(s) other than leukotriene B 4 and cysteinyl leukotrienes are involved in mosquito allergy-associated itching.Keywords: itch of mosquito allergy, 5-lipoxygense metabolite, zileuton, cutaneous nerve branch, dorsal root ganglion neuron

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“…In the attempt to suppress or delay the oxidation process as much as possible, oleic acid, linoleic acid (LA) and α-linolenic acid were encapsulated in drug delivery systems, i.e. liposomes (Shigeta et al 2004a,b) and microemulsions (Santos et al 2008), or transformed into polymeric pro-drugs (Yang et al 2000;Ishiguro et al 2002), and proposed as topical formulations.…”

Section: Introductionmentioning

confidence: 99%

Ethosomes® and transfersomes® containing linoleic acid: physicochemical and technological features of topical drug delivery carriers for the potential treatment of melasma disorders

Celia

Cilurzo

Trapasso

et al. 2011

Biomed Microdevices

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Two vesicular colloidal carriers, ethosomes® and transfersomes® were proposed for the topical delivery of linoleic acid, an active compound used in the therapeutic treatment of hyperpigmentation disorders, i.e. melasma, which is characterized by an increase of the melanin production in the epidermis. Dynamic light scattering was used for the physicochemical characterization of vesicles and mean size, size distribution and zeta potential were evaluated. The stability of formulations was also evaluated using the Turbiscan Lab® Expert based on the analysis of sample transmittance and photon backscattering. Ethosomes® and transfersomes® were prepared using Phospholipon 100 G®, as the lecithin component, and ethanol and sodium cholate, as edge activator agents, respectively. Linoleic acid at 0.05% and 0.1% (w/v) was used as the active ingredient and entrapped in colloidal vesicles. Technological parameters, i.e. entrapment efficacy, drug release and permeation profiles, were also investigated. Experimental findings showed that physicochemical and technological features of ethosomes® and transfersomes® were influenced by the lipid composition of the carriers. The percutaneous permeation experiments of linoleic acid-loaded ethosomes® and transfersomes® through human stratum corneum-epidermidis membranes showed that both carriers are accumulated in the skin membrane model as a function of their lipid compositions. The findings reported in this investigation showed that both vesicular carriers could represent a potential system for the topical treatment of hyperpigmentation disorders.

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Effects of Conjugated Linoleic Acid on Anaphylaxis and Allergic Pruritus.

Cited by 27 publications

References 22 publications

A mechanistic approach to understanding conjugated linoleic acid's role in inflammation using murine models of rheumatoid arthritis

A mechanistic approach to understanding conjugated linoleic acid's role in inflammation using murine models of rheumatoid arthritis

Possible Involvement of 5-Lipoxygenase Metabolite in Itch-Associated Response of Mosquito Allergy in Mice

Ethosomes® and transfersomes® containing linoleic acid: physicochemical and technological features of topical drug delivery carriers for the potential treatment of melasma disorders

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