Effects of Concentrated Growth Factor on Gingival Thickness in Periodontal Accelerated Osteogenic Orthodontics: A 6-Month Randomized Controlled Trial

Abstract

Background: Earlier studies have not given clear results of concentrated growth factor (CGF) on gingival thickness (GT) in periodontal accelerated osteogenic orthodontics (PAOO). This randomized controlled trial aimed to evaluate the effects of CGF on GT in patients with thin gingival phenotype undergoing PAOO.Methods: 44 patients with 264 surgical sites were recruited at baseline. All patients were randomly allocated to either a control (collagen matrix memberane) or test (CGF) group and received PAOO. GT, gingival height (GH), buccal alveolar bone thickness (BT), and buccal alveolar bone height (BH) were evaluated depending on cross-sectional CBCT images at t0 (before surgery) and t1(6 months after surgery). Results: GT were increased in both groups at t1 compared to t0. Yet, higher values were observed in the test group (from 0.95±0.26 to 1.29±0.34mm) compared to the control group (from 0.92±0.25 to 1.01±0.18mm) (p < 0.05). Moreover, in the intergroup comparison, GT at t1 in the test group was significantly higher compared to the control group (p < 0.01). Furthermore, the GT of central incisors, lateral incisors and canine teeth all showed significantly changes compared with baseline and the test group showed higher increase (p < 0.01). No statistically significant difference were found in GH, BT, BH and all clinical parameters between two groups at t1 (p > 0.05). Conclusions: Within the limitation of this study, gingival thickness could be increased by using CGF in PAOO for the patients with thin gingival phenotype. Trial registration The study was registered in Chinese Clinical Trial Registry（http://www.chictr.org.cn/index.aspx）under the number ChiCTRINR17013346, Registered 11 November 2017.