Effects of compression force on elasticity index and elasticity ratio in ultrasound elastography

Imaizumi, Akira; Sasaki, Y.; Sakamoto, Junichiro; Kamio, Takashi; Nishikawa, K.; Otonari-Yamamoto, Mika; Wako, M

doi:10.1259/dmfr.20130392

Cited by 8 publications

(8 citation statements)

References 30 publications

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“…Acute clots underwent less strain (deformation) and showed a higher EI than chronic clots. In agreement with previously described investigations , we also demonstrated that simply the assessment of a single and basic UE parameter such as the EI could almost perfectly discriminate an acute DVT from a chronic DVT. The diagnostic accuracy of this value was nearly comparable to the accuracy of the D‐dimer assay tested in this population.…”

Section: Discussionsupporting

confidence: 92%

Ultrasound elastography is useful to distinguish acute and chronic deep vein thrombosis

Mumoli

Mastroiacovo

Giorgi‐Pierfranceschi

et al. 2018

Journal of Thrombosis and Haemostasis

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Essentials Ultrasound elastography uses tissue deformation to assess the relative quantification of its elasticity. Compression and duplex ultrasonography may be unable to correctly determine the thrombus age. Ultrasound elastography may be useful to distinguish between acute and chronic deep vein thrombosis. The exact determination of the thrombus age could have both therapeutic and prognostic implications. BACKGROUND: Background Ultrasound elastography (UE) imaging is a novel sonographic technique that is commonly employed for relative quantification of tissue elasticity. Its applicability to venous thromboembolic events has not yet been fully established; in particular, it is unclear whether this technique may be useful in determining the age of deep vein thrombosis (DVT). Thus, the aim of this study was to assess the role of UE in distinguishing acute from chronic DVT. Methods Consecutive patients with a first unprovoked acute and chronic (3 months old) DVT of the lower limbs were analyzed. Patients with recurrent DVT or with a suspected recurrence were excluded. The mean elasticity index (EI) values of acute and chronic popliteal and femoral vein thrombosis were compared. The accuracy of the EI in distinguishing acute from chronic DVT was also assessed by measuring the sensitivity, specificity, positive and negative predictive values, and likelihood ratios. Results One-hundred and forty-nine patients (mean age 63.9 years, standard deviation 13.6; 73 males) with acute and chronic DVT were included. The mean EI of acute femoral DVT was higher than that of chronic femoral DVT (5.09 versus 2.46), and the mean EI of acute popliteal DVT was higher than that of chronic popliteal DVT (4.96 versus 2.48). An EI value of > 4 resulted in a sensitivity of 98.9% (95% confidence interval [CI] 93.3-99.9), a specificity of 99.1% (95% CI 94.8-99.9), a positive predictive value of 91.1% (95% CI 77.9-97.1), a negative predictive value of 98.6% (95% CI 91.3-99.9), a positive likelihood ratio of 13.23 (95% CI 93-653) and a negative likelihood ratio of 0.001 (95% CI 0.008-0.05) for acute DVT. Conclusions UE appears to be a promising technique for distinguishing between acute and chronic DVT. Larger prospective studies are warranted to confirm our preliminary findings.

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Section: Discussionsupporting

confidence: 92%

Ultrasound elastography is useful to distinguish acute and chronic deep vein thrombosis

Mumoli

Mastroiacovo

Giorgi‐Pierfranceschi

et al. 2018

Journal of Thrombosis and Haemostasis

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“…18 Another study comparing the EI with the elasticity ratio (ER), latter obtained as the ratio of EI of the lesion and EI of the reference, suggested that EI may solely be used for evaluation of soft tissues. 19 We also found ECI (same as EI) to have a high diagnostic accuracy, to be easily reproducible and more objective. We suggest that ECI, a quantitative elastography parameter, must be utilized for further characterization of the lesion in addition to conventional sonography, whenever available in the ultrasonography unit.…”

Section: Discussionmentioning

confidence: 58%

Ultrasonographic Elasticity Contrast Index of Palpable Breast Lumps

Jha

2018

J Nepal Med Assoc

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Introduction: Elastrography used in addition to grey scale sonography increases its specificity. Elasticity contrast index (ECI) is based on strain elastrography and being a quantitative parameter, maybe more easy to obtain and reproducible while researches has been done in ECI in thyroid lesions, this is the first study, to the best of our knowledge to evaluate in breast lesions. This study was done to evaluate the diagnostic accuracy of Elasticity Contrast Index (ECI) in differentiating benign from malignant lesions of breast and to determine its cutoff value. Methods: This is a descriptive cross-sectional study done at tertiary health care centre, which involved retrospective evaluation of data collected from September 2016 to March 2017. Conventional sonography was done followed by elastography on commercially available ultrasound machine. ECI was calculated in thyroid protocol available in the unit. Histopathological diagnosis was obtained for all the lesions and taken as gold standard. Results: A total of 89 breast lumps were evaluated, of which was 61 (69.3%) were benign and 27 (30.7%) malignant on histopathology. Independent t test revealed the average ECI value of benign lesions was 2.48 and malignant 5.1. Receiver operating curve showed ECI value of 3.25 as the cutoff, above which the lesions were malignant. Conclusions: ECI is a quantitative elastography technique which can be easily used as an adjunct during breast sonography and can increase its specificity for diagnosing a lesion as malignant. This could reduce the number of false positive biopsies.

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“…An experimental study clarified that the location of the reference areas did not affect the strain ratio, which corresponded to the EI ratio in the present study when the objective area was surrounded by a homogeneous structure in which the reference ROIs were set. 13 This condition, however, is rarely found, especially in in vivo examinations of skeletal muscles. Although subcutaneous fat with enough thickness might be a suitable reference when the strain values (the EIs) can be measured and can be used for comparison of values of an individual, it is not adequate for comparing such values between individuals.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the masseter muscle elasticity with the use of acoustic coupling agents as references in strain sonoelastography

Nakayama

Ariji²,

Nishiyama³

et al. 2015

Dentomaxillofacial Radiology

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Objectives: To verify the use of a single coupling agent as a reference to obtain the elasticity index (EI) ratios and to investigate the EI ratios of the masseter muscles of healthy volunteers. Methods: Muscle phantoms with known elasticity (20, 40 and 60 kPa in the Young's modulus) were examined by strain-type sonoelastography using a coupling agent as the reference. Eight examiners tested soft (with 7 kPa) and hard (with 40 kpa) reference coupling agents separately. The correlation coefficients were determined between the EI ratio and Young's modulus of muscle phantoms. The interclass correlation coefficients were calculated for inter-and intraexaminer agreement. Results: Strong correlations were found between the EI ratios and Young's modulus for both soft and hard references. The variations of the EI ratios were larger with soft coupling agents than those with hard coupling agents, and they increased in phantoms with 60 kPa elasticity. There were no differences in the EI ratios of the masseter muscle at rest between males and females or between the right and left sides. The ratio increased during clenching. Conclusions: The hard reference coupling agent was suitable for obtaining EI ratio of the masseter muscle. No differences were found in the EI ratios of the masseter muscle either between sexes or between the right and left sides at rest, and the ratios increased with the widening of their variations during clenching.

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Effects of compression force on elasticity index and elasticity ratio in ultrasound elastography

Cited by 8 publications

References 30 publications

Ultrasound elastography is useful to distinguish acute and chronic deep vein thrombosis

Ultrasound elastography is useful to distinguish acute and chronic deep vein thrombosis

Ultrasonographic Elasticity Contrast Index of Palpable Breast Lumps

Evaluation of the masseter muscle elasticity with the use of acoustic coupling agents as references in strain sonoelastography

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