Effects of compound 4880 on dextran-induced paw edema and histamine content of inflammatory exudate

Nishida, Shinichi; Tomizawa, Setsuo

doi:10.1016/0006-2952(80)90174-4

Cited by 10 publications

(7 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is known that histamine and serotonin are the principal mediators of dextran-induced paw edema. 17,18 The fact that EEEm inhibits the dextran edema could imply that it inhibits either the degranulation of mastocytes and thus the release of mediators, histamine, and serotonin or their actions at the receptor level.…”

Section: Discussionmentioning

confidence: 99%

Topical and Systemic Anti-Inflammatory Effects of Echinodorus macrophyllus (Kunth) Micheli (Alismataceae)

Tanus-Rangel

Santos

Lima

et al. 2010

Journal of Medicinal Food

View full text Add to dashboard Cite

Echinodorus macrophyllus leaf has been used in Brazilian folk medicine to treat inflammatory conditions and kidney dysfunctions. The present study evaluated the effects of leaf ethanolic extract from E. macrophyllus (EEEm) in acute and subchronic models of inflammation. The EEEm was found to cause significant and potent inhibition of carrageenan- and dextran-induced paw edema in rats and marked decreases in the exudate volume and leukocyte migration in rats with carrageenan-induced pleurisy, the vascular permeability increase induced by intraperitoneal acetic acid, and the croton oil-induced topical ear edema in mice. On the other hand, the EEEm was not active in the test model of cotton pellet-induced granuloma in rats. Phytochemical analysis with E. macrophyllus leaves revealed the presence of triterpenoids, steroids, flavones, flavonols, and xanthones. Two flavonoids were isolated from the ethyl acetate fraction and identified as isovitexin and vitexin. Our results support the traditional use of E. macrophyllus leaves in the treatment of acute inflammatory conditions.

show abstract

Section: Discussionmentioning

confidence: 99%

Topical and Systemic Anti-Inflammatory Effects of Echinodorus macrophyllus (Kunth) Micheli (Alismataceae)

Tanus-Rangel

Santos

Lima

et al. 2010

Journal of Medicinal Food

View full text Add to dashboard Cite

show abstract

“…Data from the experiment on Cg‐induced oedema also show that Gln depletion by MSO does not interfere with mast cell degranulation, which is mainly responsible for Cg paw oedema during the first 1·5 hr 32 . This finding was confirmed by the fact that MSO had no effect on Dx‐induced paw oedema, which is dependent on mast cell degranulation 55–57 …”

Section: Discussionmentioning

confidence: 80%

Glutamine depletion potentiates leucocyte‐dependent inflammatory events induced by carrageenan or Clostridium difficile toxin A in rats

Nascimento¹,

Sousa²,

Martins³

et al. 2005

Immunology

View full text Add to dashboard Cite

SummaryThis research investigated the effect of glutamine (Gln) depletion on leucocyte-dependent inflammatory events. Rats were treated intraperitoneally, 16 hr prior to the peak of every parameter evaluated, with either 0Á9% NaCl, methionine-sulphoximine (MSO, an inhibitor of endogenous Gln synthesis, 25 mg/kg) or with MSO + Gln (MSO as above plus Gln 3 g/kg in three doses). MSO-induced Gln depletion increased paw oedema induced both by carrageenan (Cg) and by Clostridium difficile toxin A (TxA) (66Á2% and 45Á5%, respectively; P < 0Á05). In dextran-injected animals, oedema and myeloperoxidase (MPO) activity were not modified by Gln depletion. In Cg-treated paws, Gln depletion increased MPO activity by 44% (P < 0Á05), interleukin-1b (IL-1b) and tumour necrosis factor-a (TNF-a) concentrations by 47% and 52%, respectively (P < 0Á05), and immunostaining for TNF-a in paw tissue. In TxA-injected paws, Gln depletion increased MPO activity (46%; P < 0Á05). Gln depletion increased Cg-and TxA-induced neutrophil migration to subcutaneous air pouches by 56% and 77% (P < 0Á05), respectively, but did not affect migration induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP). Gln infusions reversed all the effects of MSO. Leucocyte counts did not differ between groups. Gln depletion potentiates acute inflammation, possibly by increasing neutrophil migration through resident cell activation and production of IL-1b and TNF-a. Gln supplementation reverses these effects and may be useful during inflammatory catabolic stress.

show abstract

“…after dextran injection. It triggers the release of kinins, lipoxygenase derived products and histamine and serotonin from mast cells (Ankier;Neat, 1972;Nishida;Tomizawa, 1980;Van Wauwe;Goossens, 1989).…”

Section: Resultsmentioning

confidence: 99%

Comparative anti-inflammatory and antinociceptive effects of terpenoids and an aqueous extract obtained from Croton cajucara Benth

Perazzo¹,

Carvalho²,

Rodrigues³

et al. 2007

Rev. bras. farmacogn.

View full text Add to dashboard Cite

RESUMO: "Avaliação comparativa dos efeitos anti-infl amatório e antinociceptivo de terpenóides e de extrato aquoso obtidos de Croton cajucara Benth". O 19-nor-clerodano trans-crotonina (CTN) e o triterpeno ácido acetil aleuritólico (AAA), isolados das cascas do caule de Croton cajucara Benth (Euphorbiaceae), uma planta tradicional da Região Amazônica do Brasil, bem como o extrato aquoso (EA) das cascas do caule deste Croton, foram submetidos a experimentos farmacológicos utilizando animais, para avaliação das atividades anti-infl amatória e antinociceptiva. A administração oral de AAA (50 mg/kg), CTN (50 mg/kg) ou AE (300 mg/ kg) inibiram as contorções em ratos, induzidas por ácido acético. Os terpenóides AAA e CTN, bem como o extrato polar EA, inibiram signifi cativamente o edema de pata em ratos, induzido por carragenina. As inibições foram observadas em todos os intervalos de medições, tendo sido evidenciado melhores inibições para os terpenóides AAA (47,7%, após a primeira hora) e CTN (54,4%, após a segunda hora). Evidenciou-se ainda, após 90 minutos do estímulo, signifi cante inibição no edema induzido por dextrana (31,9% para CTN e 28,5% para AAA) e por histamina (43,2% para CTN e 40,5% para AAA). Estes resultados confi rmam o uso popular de Croton cajucara na região Amazônica do Brasil, no combate a infl amações. Unitermos:Croton cajucara, ácido acetil aleuritólico, trans-crotonina, anti-infl amatório, antinociceptivo. ABSTRACT:The 19-nor-clerodane trans-crotonin (CTN) and the triterpene acetyl aleuritolic acid (AAA), isolated from the stem bark of Croton cajucara Benth (Euphorbiaceae), a traditional medicinal plant from Amazon region of Brazil, as well as the aqueous extract (AE) from its stem bark, were submitted to pharmacological screening for anti-infl ammatory and antinociceptive activities in animal models. The oral administration of AAA (50 mg/kg), CTN (50 mg/kg) or AE (300 mg/kg) inhibited the acetic acid-induced writhing in mice. The AE, CTN and AAA had shown signifi cant inhibition of carrageenin-induced edema in rats, in all time intervals measured after the injection of the stimulus, with the greatest inhibition at the fi rst hour for AAA (47.7%) and the second hour for CTN (54.4%). They have also exhibited signifi cant inhibition in the dextran-induced edema 90 minutes after the stimulus: 31.9% for CTN and 28.5% for AAA. In the histamine-induced edema, the inhibition showed by CTN and AAA were 43.2% and 40.5%, respectively, 90 minutes after the injection of stimulus. This study extends and supports the popular medicine and folkloric uses of Croton cajucara in the Amazon region of Brazil.

show abstract

Effects of compound 4880 on dextran-induced paw edema and histamine content of inflammatory exudate

Cited by 10 publications

References 15 publications

Topical and Systemic Anti-Inflammatory Effects of Echinodorus macrophyllus (Kunth) Micheli (Alismataceae)

Topical and Systemic Anti-Inflammatory Effects of Echinodorus macrophyllus (Kunth) Micheli (Alismataceae)

Glutamine depletion potentiates leucocyte‐dependent inflammatory events induced by carrageenan or Clostridium difficile toxin A in rats

Comparative anti-inflammatory and antinociceptive effects of terpenoids and an aqueous extract obtained from Croton cajucara Benth

Contact Info

Product

Resources

About