Effects of combining modern recovery techniques with neurotrophic medication and standard treatment in stroke patients

Uivaroșan, Diana; Ţiţ, Delia Mirela; Iovan, Ciprian; Nistor-Cseppentö, Delia Carmen; Endres, Laura; Lazăr, Liviu; Sava, Cristian; Sabau, Anca Maria; Buhaş, Camelia Liana; Moleriu, Lavinia Cristina; Bungău, Simona; Aleya, Lotfi

doi:10.1016/j.scitotenv.2019.05.070

Cited by 20 publications

(17 citation statements)

References 31 publications

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“…Newly formed vessels can be observed starting the third day after stroke. Mostly visible at the outskirts of the ischemic area, angiogenesis is also evident inside necrotic-associated areas (12).…”

Section: Introductionmentioning

confidence: 99%

The Alberta Stroke Program Early CT score (ASPECTS): A predictor of mortality in acute ischemic stroke

et al. 2021

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Stroke is one of the leading causes of mortality globally and a main cause of disability. The objective of this study was to evaluate the importance and utility of the Alberta Stroke Program Early CT Score (ASPECTS) as a mortality predictor factor in diabetic vs. non-diabetic patients with acute ischemic stroke (AIS), correlated with age, monocyte values, and high-sensitivity cardiac troponin I (hs-cTnI). The prospective longitudinal observational study included 340 patients with AIS divided into two groups: diabetics and non-diabetics. ASPECTS was evaluated within the first 24 h after admission to the center. The ASPECTS was lower in the group of diabetic patients on average 4.9 vs. 6.05 (P<0.0001). As the age of the patients increased, the lower the ASPECTS and the higher infarct size, indicating a statistically significant (P<0.0001) result. The optimal correlation was observed between infarct size (ASPECTS) and hs-cTnI serum level [95% confidence interval (CI): -0.3216 to -0.1193; P<0.0001]. Almost 94% of patients who had an ASPECTS higher than 3 points on admission survived, resulting in a favorable outcome and a very good predictability of the score (95% CI: 0.85 to 0.926, P<0.0001). The ASPECTS is a mortality predictor, its value correlating inversely with the severity and evolution of patients, confirming a good predictability with good specificity, sensitivity and area under the curve.

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Section: Introductionmentioning

confidence: 99%

The Alberta Stroke Program Early CT score (ASPECTS): A predictor of mortality in acute ischemic stroke

et al. 2021

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“…It is a major health problem both for the negative effect on the motor and cognitive abilities, and the quality of life of the survivor of the disease and his family [3,4]. After a stroke, the patient remains with a major and profound disability caused by many locomotor impairments, communication, behavioural, locomotor independence, orientation and social integration [5]. These long-term disabilities generate huge socio-economic costs [6].…”

Section: Introductionmentioning

confidence: 99%

Financial Burden of Stroke Reflected in a Pilot Center for the Implementation of Thrombolysis

et al. 2020

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Stroke represents a serious illness and is extremely relevant from the public health point of view, implying important social and economic burdens. Introducing new procedures or therapies that reduce the costs both in the acute phase of the disease and in the long term becomes a priority for health systems worldwide. The present study quantifies and compares the direct costs for ischemic stroke in patients with thrombolysis treatment versus conservative treatment over a 24-month period from the initial diagnosis, in one of the 7 national pilot centres for the implementation of thrombolytic treatment. The significant reduction (p < 0.001) of the hospitalization period, especially of the days in the intensive care unit (ICU) for stroke, resulted in a significant reduction (p < 0.001) of the total average costs in the patients with thrombolysis, both at the first hospitalization and for the subsequent hospitalizations, during the period followed in the study. It was also found that the percentage of patients who were re-hospitalized within the first 24-months after stroke was significantly lower (p < 0.001) among thrombolyzed patients. The present study demonstrates that the quick intervention in cases of stroke is an efficient policy regarding costs, of Romanian Public Health System, Romania being the country with the highest rates of new strokes and deaths due to stroke in Europe.

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“…Thus, it is persuadable that CBs may affect the survival of neurons and conserve various regulatory synaptic functions during PD acting through CB1 receptor at “immune” CB2 receptor and “neuronal” receptors, delineating the strong pharmacological action to effect simultaneously, both synaptic and immune functions within CNS borders [ 127 ]. Altogether, the past and latest data encouraged the concept of the significant role of the endocannabinoid signalling in the motor control system [ 128 , 129 ]. Three significant pieces of evidence assist these findings.…”

Section: Experimental Studies Implying Potential Interventions Of mentioning

confidence: 99%

Distinctive Evidence Involved in the Role of Endocannabinoid Signalling in Parkinson’s Disease: A Perspective on Associated Therapeutic Interventions

Behl

Kaur

Bungău

et al. 2020

IJMS

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Current pharmacotherapy of Parkinson’s disease (PD) is symptomatic and palliative, with levodopa/carbidopa therapy remaining the prime treatment, and nevertheless, being unable to modulate the progression of the neurodegeneration. No available treatment for PD can enhance the patient’s life-quality by regressing this diseased state. Various studies have encouraged the enrichment of treatment possibilities by discovering the association of the effects of the endocannabinoid system (ECS) in PD. These reviews delineate the reported evidence from the literature on the neuromodulatory role of the endocannabinoid system and expression of cannabinoid receptors in symptomatology, cause, and treatment of PD progression, wherein cannabinoid (CB) signalling experiences alterations of biphasic pattern during PD progression. Published papers to date were searched via MEDLINE, PubMed, etc., using specific key words in the topic of our manuscript. Endocannabinoids regulate the basal ganglia neuronal circuit pathways, synaptic plasticity, and motor functions via communication with dopaminergic, glutamatergic, and GABAergic signalling systems bidirectionally in PD. Further, gripping preclinical and clinical studies demonstrate the context regarding the cannabinoid compounds, which is supported by various evidence (neuroprotection, suppression of excitotoxicity, oxidative stress, glial activation, and additional benefits) provided by cannabinoid-like compounds (much research addresses the direct regulation of cannabinoids with dopamine transmission and other signalling pathways in PD). More data related to endocannabinoids efficacy, safety, and pharmacokinetic profiles need to be explored, providing better insights into their potential to ameliorate or even regress PD.

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Effects of combining modern recovery techniques with neurotrophic medication and standard treatment in stroke patients

Cited by 20 publications

References 31 publications

The Alberta Stroke Program Early CT score (ASPECTS): A predictor of mortality in acute ischemic stroke

The Alberta Stroke Program Early CT score (ASPECTS): A predictor of mortality in acute ischemic stroke

Financial Burden of Stroke Reflected in a Pilot Center for the Implementation of Thrombolysis

Distinctive Evidence Involved in the Role of Endocannabinoid Signalling in Parkinson’s Disease: A Perspective on Associated Therapeutic Interventions

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