“…The bioactivities of low molecular weight FF were found to mimic those of heparin, a glycosaminoglycan of animal origin with a molecular weight of about 15 kDa. As a consequence, depolymerization methods of raw fucoidans were developed: by acid hydrolysis [ 9 ], by radical cleavage [ 34 ], by enzymatic degradation (fucoidanases) from bacteria as well as digestive secretion of mollusk [ 35 , 36 , 37 , 38 , 39 ], and by gamma irradiation [ 40 , 41 , 42 ]. These methods could often cause structural alteration (like debranching and desulfation) likely affecting the biological activities.…”