Effects of combined oral contraception containing drospirenone on premenstrual exacerbation of Meniere’s disease: Preliminary study

Caruso, Salvatore; Mauro, Diletta; Maiolino, Luigi; Grillo, Caterina; Rapisarda, Agnese Maria Chiara; Cianci, Stefano

doi:10.1016/j.ejogrb.2018.03.015

Cited by 9 publications

(3 citation statements)

References 28 publications

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“…The reasons for these differences are not clear but have been hypothesized in some studies to be related to the menstrual cycle [9]. Hormone fluctuations from the menstrual cycle influence a multitude of processes, including sensory perception [11][12][13], sexual desire [14], cognitive function [15], and emotional processing [15]; however, few studies have examined the relationship these hormones have with the GI system. Understanding any mechanisms linking menstruation to bowel discomfort will aid in the development of targeted treatments and potentially provide a substantial impact on the quality of life and/or well-being of women who experience discomfort during and around menstruation.…”

Section: Introductionmentioning

confidence: 99%

Stool frequency and form and gastrointestinal symptoms differ by day of the menstrual cycle in healthy adult women taking oral contraceptives: a prospective observational study

et al. 2020

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Background: Little is known about how the menstrual cycle affects gastrointestinal function and self-reported stress in young, healthy women taking oral contraceptives (OC). This study prospectively characterized gastrointestinal function and symptoms on each day throughout the menstrual cycle. Methods: Healthy women aged 18-35 years (n = 78) who took OC participated in the 5-week observational study. Stool frequency, self-reported stress, stool form measured by the Bristol Stool Form Scale (BSFS), and gastrointestinal symptoms measured by a modified version of the Gastrointestinal Symptom Rating Scale (GSRS) were assessed daily. GSRS scores were reported (1 = no discomfort at all, 7 = very severe discomfort) and were averaged for individual syndrome scores or summed for the total score. The validated, weekly version of the GSRS was completed at two time points to reflect menstruation and 1 week prior to menstruation (n = 72). Outcomes were analyzed in linear mixed models with the Dunnett's post hoc test against day 1 of menstrual bleeding or with nonparametric tests.

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Section: Introductionmentioning

confidence: 99%

Stool frequency and form and gastrointestinal symptoms differ by day of the menstrual cycle in healthy adult women taking oral contraceptives: a prospective observational study

et al. 2020

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“…In a previous study, peripheral vestibular disorder commonly showed a high score for complaints of dizziness (51 points for females, 47 points for males), and dizziness in Meniere disease patients was also significantly high at 66.8 points. [ 51 ] The reason for this difference is that people with Meniere disease or peripheral vestibular disorder more commonly complain of severe dizziness than people with cardiovascular epilepsy, which is predicted to be more heavily influenced by anatomical and pathological factors.…”

Section: Discussionmentioning

confidence: 99%

The relationship between stress and sleep quality: The mediating effect of fatigue and dizziness among patients with cardiovascular disease

Park

2023

Medicine

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Cardiovascular disease is the leading cause of non-noncommunicable disease mortality worldwide. Therefore, this study analyzes the mediating effect of dizziness and fatigue in the relationship between stress and sleep quality in patients with heart disease. This study was conducted on patients with heart disease diagnosed by a cardiologist from December 7, 2021 to August 30, 2022 at the Outpatient Department of Cardiology at Hanyang University Hospital in Guri-si, Gyeonggi-do. To verify the serial multiple mediation effect, serial multiple mediation analysis was performed using SPSS Macro Process Model 6 as the most appropriate verification method for this study. The analysis indicated that the more dizziness a participant experienced, the more severe their physical and psychological fatigue and the poorer their quality of sleep. Also, the more severe the physical fatigue, the worse the psychological fatigue and the worse the quality of sleep. In other words, the more severe the psychological fatigue, the poorer the quality of sleep. In summary, in the relationship in which stress in patients with heart disease affects sleep quality, stress is a variable that directly affects sleep quality, and this means that the stress of patients with heart disease can affect the quality of sleep through the parameters, dizziness and fatigue, sequentially; this research model can thus be considered a partial mediator model. Fatigue in patients with cardiovascular disease had a direct effect on sleep quality, and there was a mediating effect through dizziness and fatigue in the relationship between stress and sleep quality. Therefore, it is necessary to develop a sleep management program that can improve the quality of sleep in patients with cardiovascular disease as well as a nursing intervention plan that can alleviate fatigue and control stress in such patients.

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“…Consequently, the present study indicated that the benefits obtained by postmenopausal women with MD using DRSP/E2 treatment may be due to the type, dosage, combination and regimen of progestogen and E2. Furthermore, the use of an oral hormonal contraceptive containing DRPS and ethinylestradiol was effective in improving the exacerbation of MD in fertile women affected by premenstrual syndrome ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of hormone therapy containing 2 mg drospirenone and 1 mg 17β‑estradiol on postmenopausal exacerbation of Meniere's disease: Preliminary study

et al. 2021

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The present study aimed to evaluate the effects of 2 mg drospirenone (DRSP) and 1 mg 17β-estradiol (E2) hormone therapy (HT) in combination with rehabilitation therapy for postmenopausal women with Meniere's disease (MD). The combined drug hormone treatment was denoted as DRSP/E2. A total of 65 postmenopausal female patients with MD and severe distress were enrolled in the present prospective study. A total of 31 women comprised the study group (group A), undergoing HT and rehabilitation therapy, whereas 34 women who opted for rehabilitation therapy alone comprised the control group (group B). Vestibular function and distress associated with MD were assessed by stabilometry and the Dizziness Handicap Inventory (DHI) questionnaire, respectively. The data were collected at baseline and during the 3- and 6-month follow-up visits. The areas of the stabilometric ellipses exhibited a higher reduction in group A compared with group B with regard to the baseline values at both follow-up assessments (P<0.001). At baseline, both groups exhibited severe self-perceived discomfort, with similar DHI scores of 72.3±3.7 (group A) and 70.6±3.9 (group B; P=0.07). At the 3-month follow-up, both groups underwent a gradual improvement, which was significantly higher in group A (47.5±3.7) compared with in group B (64.2±3.3; P<0.001). At the 6-month follow-up, the DHI scores were improved in group A (43.4±3.4) compared with in group B (58.5±3.1; P<0.001). Therefore, DRSP/E2 HT was effective in reducing the fluid overload, which is characteristic of MD. The findings of the present study demonstrated that integrated therapy based on the administration of DRSP/E2 HT and rehabilitation may be more effective compared with rehabilitation alone for the management of postmenopausal exacerbation of MD.

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Effects of combined oral contraception containing drospirenone on premenstrual exacerbation of Meniere’s disease: Preliminary study

Cited by 9 publications

References 28 publications

Stool frequency and form and gastrointestinal symptoms differ by day of the menstrual cycle in healthy adult women taking oral contraceptives: a prospective observational study

Stool frequency and form and gastrointestinal symptoms differ by day of the menstrual cycle in healthy adult women taking oral contraceptives: a prospective observational study

The relationship between stress and sleep quality: The mediating effect of fatigue and dizziness among patients with cardiovascular disease

Effects of hormone therapy containing 2 mg drospirenone and 1 mg 17β‑estradiol on postmenopausal exacerbation of Meniere's disease: Preliminary study

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