Effects of combined exercise training on immunological, physical and biochemical parameters in individuals with HIV/AIDS

Abstract

The practice of exercise has shown to be beneficial to quality of life of individuals with HIV/AIDS. Thus, the present study analysed the effects of a combined exercise training in persons living with HIV/AIDS. Ten participants participated in the present study. The following variables were analysed: viral load and cell counts for TCD4+/TCD8; maximal oxygen consumption (VO2max); total mass, absolute fat mass, relative fat mass, absolute lean mass, relative lean mass and body mass index; fasting glycaemia, fasting insulinaemia, homeostatic model assessment (HOMA) index (insulin resistance - homeostatic model assessment (IR-HOMA)); total cholesterol, triglycerides, high-density lipoprotein (HDL), very low-density lipoprotein (VLDL), low-density lipoprotein (LDL); superoxide dismutase, catalase, glutathione peroxidase activities; thiobarbituric acid reactive substances. The combined exercise training consisted of resistance exercises plus aerobic training (60 min · session(-1), three times per week, during 20 weeks). The number of TCD4+ cells, absolute lean mass and relative lean mass, muscle strength for the 45° leg press, seated row and triceps extension, HDL-c levels as well as VO2max increased post-training. The activity of superoxide dismutase, catalase, glutathione peroxidase enzymes and thiobarbituric acid reactive substances levels were diminished post-training. Finally, it can be concluded that combined exercise training is able to change positively several variables related to health of individuals with HIV/AIDS, mainly the immune system as well as antioxidant mechanisms re-establishment.

Cardiorespiratory fitness levels and moderators in people with HIV: A systematic review and meta-analysis

“…Our meta-analysis did however show that a better CRF response is obtained in response to moderate, as opposed to high intensity exercise. Previous research already indicated that moderate intensity physical activity improves the immune function in PLWH (Ezema et al, 2014;Garcia et al, 2014), while high-intensity exercise is known to have immunosuppressive effects (d 'Ettorre et al, 2014). However, data should be interpreted with caution due to the very limited data available.…”

Parâmetros bioquímicos e cinética de lactato sanguíneo de sujeitos HIV+ submetidos ao treinamento físico combinado

“…Intervenções não-medicamentosas vêm sendo aplicadas para evitar/minimizar as consequências negativas advindas da associação entre a infecção do vírus HIV e o uso da HAART; dentre elas está a adesão ao programa de exercícios físicos regulares 2,5,[8][9][10]12 . Diversos estudos são encontrados na literatura mostrando os benefícios advindos do treinamento físico de força e aeróbio, tais como: aumento e manutenção do consumo máximo de oxigênio, adaptações neurais, aumento da massa e força muscular bem como redução do percentual de gordura, melhora nos perfi s lipídico e glicêmico, diminuição do risco coronariano, síntese de novas mitocôndrias e melhor vascularização (angiogênese), além da manutenção da carga viral e o aumento das células TCD4+ 5,9,[13][14] . No presente estudo, o intuito foi obter os efeitos desejados nas variáveis referentes aos treinamentos resistido e aeróbio em um curto espaço de tempo e, para isso, associou-se em uma mesma sessão de treino os dois componentes, sendo este conhecido como treinamento físico combinado (TFC).…”

“…Os estudos de Perna et al 33 e Garcia et al 14 , este último realizado pelo nosso grupo de pesquisa, corroboram com nossos achados. O estudo de Perna et al 33 avaliou o efeito de 12 semanas de treinamento aeróbio sobre a função cardiopulmonar e contagem de células TCD4+ de três grupos vivendo com HIV/AIDS (grupo controle, grupo exercício -completou o protocolo, grupo exercício -não completou o protocolo).…”

Effets D’un Programme D’entrainement De 8 Semaines Chez Des Femmes Infectees Du Vih Sous Traitement Antiretroviral (Arv) En Cote d’Ivoire

“…Pratiquée de façon régulière, l'activité physique a de multiples effets bénéfiques sur la santé selon la durée, la nature ou le type d'exercice physique (Paes Lda et al, 2015, Garcia et al, 2014. En effet, l'activité physique peut agir sur les différents facteurs de risque cardiovasculaire (Fagard, 2006), sur l'évolution du cancer (Booth, Roberts and Laye, 2012), sur la qualité de vie des personnes vivants avec le VIH/SIDA (Garcia, Fraga, Vieira, Silva, Trombeta, Navalta, Prestes, Voltareli, 2014).…”

“…En effet, l'activité physique peut agir sur les différents facteurs de risque cardiovasculaire (Fagard, 2006), sur l'évolution du cancer (Booth, Roberts and Laye, 2012), sur la qualité de vie des personnes vivants avec le VIH/SIDA (Garcia, Fraga, Vieira, Silva, Trombeta, Navalta, Prestes, Voltareli, 2014). La présente étude analyse l'influence de l'exercice musculaire chronique d'intensité modérée dans un contexte de loisir (entraînement fitness) sur l'état de santé physique et immunologique chez 48 femmes infectées du virus de l'immunodéficience humaine et sous traitement antirétroviraux (ARV).…”