Effects of combined calcium and vitamin D supplementation on osteoporosis in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials

Liu, Chunxiao; Kuang, Xiaotong; Li, Duo; Guo, Xiaofei; Deng, Qingxue; Li, Duo

doi:10.1039/d0fo00787k

Cited by 83 publications

(69 citation statements)

References 45 publications

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“…Although SD is a broad range of vitamin D indicator, the long SD group was associated with a lower occurrence of osteoporosis in our study. This finding is consistent with previous studies exploring the links of vitamin D obtained via dietary intake or supplementation, serum 25(OH)D, and sunlight exposure with BMD, osteoporosis, or fractures [20,21,23,33]. One experimental study using rats reported that PTH was significantly reduced in the sun-exposed vitamin D-deficient group (67.69 ± 13.18 pg/ml) compared to the levels in the vitamin D-supplemented rats (78.93 ± 8.31 pg/ml) and vitamin D-deficient rats (86.05 ± 9.67 pg/ml) [22].…”

Section: Discussionsupporting

confidence: 93%

“…An increasing number of studies are being conducted on the association between vitamin D and BMD. However, the intake of vitamin D alone is not evident to prevent fractures [ 18 , 19 ]; instead, review studies have suggested that combining vitamin D with calcium intake is associated with a lower risk of osteoporosis and fractures [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Associations between Physical Activity, Sunshine Duration and Osteoporosis According to Obesity and Other Lifestyle Factors: A Nested Case–Control Study

Min

Yoo

Choi

2021

IJERPH

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(1) Background: The purpose of the study was to evaluate the associations between physical activity (PA), sunshine duration (SD) and the occurrence of osteoporosis according to lifestyle status. (2) Methods: Data from the Korean National Health Insurance Service–National Sample Cohort (NHIS-NSC) collected from 2009 to 2015 were used. Osteoporosis (n = 19,351) and control (n = 38,702) participants were matched in a 1:2 ratio according to age, sex, income, and region of residence. PA was classified as moderate- to high-intensity PA (MHPA) or low-intensity PA (LPA) based on the International Physical Activity Questionnaire (IPAQ). SD was classified as short (≤6 h) or long (>6 h). Conditional logistic regression was used to calculate the odds ratios (ORs) with 95% confidence intervals (CIs) of MHPA and long SD for the occurrence of osteoporosis. Subgroup analyses were performed according to SD (or PA), obesity, smoking, and alcohol consumption. (3) The adjusted OR of MHPA for osteoporosis was 0.90 (95% CI = 0.87–0.94). The results were consistent in the age/sex, SD, obesity, smoking, and alcohol consumption subgroups, but not the <60-year-old male and underweight subgroups. The adjusted OR of long SD for osteoporosis was 0.96 (95% CI = 0.93–1.00). The findings were consistent in the <60-year-old female, obese, nonsmoker, and <1 time a week alcohol consumption subgroups. (4) Conclusions: We suggest that both higher intensity of PA and long SD could decrease the risk of osteoporosis. Specifically, PA could decrease the risk of osteoporosis in individuals with most characteristics except male sex or underweight. Long SD could decrease the risk of osteoporosis in young females, obese individuals, nonsmokers, and individuals with lower alcohol consumption.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Associations between Physical Activity, Sunshine Duration and Osteoporosis According to Obesity and Other Lifestyle Factors: A Nested Case–Control Study

Min

Yoo

Choi

2021

IJERPH

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“…Such an effect was not observed at the femoral neck or lumbar spine. These observations are in agreement with a recent meta-analysis demonstrating a beneficial effect of VitD supplements and enriched foods, along with calcium, on BMD and reduction in fragility fractures in postmenopausal women [33].…”

Section: Discussionsupporting

confidence: 92%

Association of GC Variants with Bone Mineral Density and Serum VDBP Concentrations in Mexican Population

Rivera‐Paredez

Hidalgo‐Bravo

León-Reyes

et al. 2021

Genes

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Vitamin D-binding protein (VDBP) is encoded by the GC gene and is an active participant in the control of bone metabolism. However, the effect of its major variants on VDBP concentration and bone mineral density (BMD) remains unclear. Our aim was to analyze the effect of major GC variants on serum VDBP concentration and BMD. We recruited individuals from the Health Workers Cohort Study, which includes employees of the Mexican Institute of Social Security (IMSS). A total of 1853 adults were included. The single nucleotide polymorphisms (SNPs) rs7041 and rs4588 were genotyped to identify the three best characterized haplotypes of GC. Serum VBDP, 25(OH)D and BMD were also measured. Among women, the G allele of rs7041 was associated with higher VDBP and BMD compared to homozygous TT. The A allele of rs4588 was associated with lower VDBP and BMD compared to CC homozygous. In men, GC variants were only associated with VDBP levels. We did not observe an association between free/bioavailable 25(OH)D and BMD in men and women. Our results support an association of VDBP in bone health. The G and C alleles, from rs7041 and rs4588, respectively, are associated with high concentrations of VDBP and BMD in this sample of Mexican postmenopausal women.

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“…Diet is a significant modifiable factor involved in the occurrence and progression of chronic metabolic diseases, such as osteoporosis [1]. Previous studies have shown that the risk of osteoporosis is related to the intake of multiple nutrients, including minerals such as calcium [2] and zinc [3], vitamins such as vitamin D [4] and vitamin K [5], and other nutrients [6,7]. Many researchers have also found that adherence to specific dietary patterns, such as the Mediterranean diet [8,9], is associated with a lower risk of osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

Association between Healthy Eating Index-2015 total and component food scores with osteoporosis in middle-aged and older Americans: a cross-sectional study with U.S. National Health and Nutrition Examination Survey

Fan

Zhang

2021

Osteoporos Int

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We used NHANES data to explore the association between dietary quality estimated by the HEI-2015 and osteoporosis in middle-aged and elderly US adults. We found that higher dietary quality is significantly associated with a reduced risk of osteoporosis among middle-aged and elderly Americans. Introduction Through this research, we assess whether increasing the overall dietary quality reduces the risk of osteoporosis.

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Effects of combined calcium and vitamin D supplementation on osteoporosis in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials

Abstract: The aim of the present study was to explore whether combined calcium and vitamin D supplementation is beneficial for osteoporosis in postmenopausal women.

Cited by 83 publications

References 45 publications

Associations between Physical Activity, Sunshine Duration and Osteoporosis According to Obesity and Other Lifestyle Factors: A Nested Case–Control Study

Associations between Physical Activity, Sunshine Duration and Osteoporosis According to Obesity and Other Lifestyle Factors: A Nested Case–Control Study

Association of GC Variants with Bone Mineral Density and Serum VDBP Concentrations in Mexican Population

Association between Healthy Eating Index-2015 total and component food scores with osteoporosis in middle-aged and older Americans: a cross-sectional study with U.S. National Health and Nutrition Examination Survey

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