Effects of combined aerobic and resistance exercise on renal function in adult patients with chronic kidney disease: a systematic review and meta-analysis

Wu, Xiaoxia; Yang, Lei; Wang, Ying; Wang, Chunfeng; Hu, Rong; Wu, Yong

doi:10.1177/0269215520924459

Cited by 28 publications

(27 citation statements)

References 31 publications

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“…Taken together, these data show that sedentary habits are common in patients with CKD. As exercise can favourably modulate renal function and control of hypertension in patients with CKD [ 27 ], it represents an important intervention that has potential to improve outcomes.…”

Section: Discussionmentioning

confidence: 99%

The Indian Chronic Kidney Disease (ICKD) study: baseline characteristics

Kumar

Yadav

Sethi

et al. 2021

Clinical Kidney Journal

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Background Chronic kidney disease (CKD) is an important cause of morbidity and mortality worldwide. There is lack of information on epidemiology and progression of CKD in low-middle income countries. The Indian Chronic Kidney Disease (ICKD) study aims to identify factors that associate with CKD progression, and development of kidney failure and cardiovascular disease (CVD) in Indian CKD patients . Methods ICKD study is prospective, multicentric, cohort study enrolling patients with estimated glomerular filtration rate (eGFR) 15-60 ml/min/1.73m2 or > 60 ml/min/1.73m2 with proteinuria. Clinical details and biological samples are collected at annual visit. We analysed the baseline characteristics including socio-demographic details, risk factors, disease characteristics and laboratory measurements. In addition, we compared characteristics between urban and rural participants. Results A total of 4056 patients have been enrolled till March 31, 2020. The age was 50.3 ±11.8 years, 67.2% were males, 2/3 lived in rural areas and median eGFR was 40 ml/min/1.73m2. About 87% were hypertensive, 37% had diabetes, 22% had CVD, 6.7% had past history of acute kidney injury and 23% reported prior use of alternative drugs. Diabetic kidney disease, chronic interstitial nephritis and CKD-cause unknown were the leading causes. Rural participants had more occupational exposure and tobacco use but lower educational status and income. CIN and unknown categories were leading causes in rural participants. Conclusions The ICKD study is the only large cohort study of patients with mild-to-moderate CKD in a lower-middle income country. Baseline characteristics of study population reveal differences as compared to other cohorts.

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Section: Discussionmentioning

confidence: 99%

The Indian Chronic Kidney Disease (ICKD) study: baseline characteristics

Kumar

Yadav

Sethi

et al. 2021

Clinical Kidney Journal

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“…The factors that we found to be associated with impaired kidney function in our study are consistent with those widely reported in literature, and are not related to CKDu. For example, a recent systematic review has reported that combined aerobic and resistance exercise improves renal function, especially among patients with CKD [ 33 ]. HTN and obstructive nephropathy have been described as main causes of impaired kidney function.…”

Section: Discussionmentioning

confidence: 99%

CKD and CKDu in northern Peru: a cross-sectional analysis under the DEGREE protocol

et al. 2021

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Background This study estimated the prevalence and risk factors for decreased estimated glomerular filtration rate (eGFR) in those without known hypertension, type 2 diabetes mellitus, or heavy proteinuria as a surrogate marker for chronic kidney disease of unknown cause (CKDu) among adults in the North of Peru. Methods A cross-sectional study was conducted following the Disadvantaged Populations eGFR Epidemiology (DEGREE) Study protocol. Low eGFR was defined based on a single eGFR ≤60 mL/min/1.7m2 estimated using the CKD-EPI equation. Environmental conditions related to CKDu (i.e., work in agriculture or sugarcane, water source, heat intolerance, and pesticide exposure) were evaluated, in addition to traditional risk factors for CKD (i.e., smoking, heavy drinking, physical activity, hypertension, type 2 diabetes mellitus, urolithiasis, among others). Results A total of 1514 subjects were included in the study, mean age 45.1 (SD: 16.4), and 55.2% were females. Overall, only 26 cases (1.7%; 95%CI: 1.1–2.5%) had an eGFR < 60 mL/min/1.7m2 compatible with CKD definition; when those with hypertension and type-2 diabetes or heavy proteinuria were excluded, according to the DEGREE protocol, the estimate fell to 0.9% (95%CI: 0.4–1.5%). Low physical activity levels (OR = 1.99; 95%CI: 1.18–3.34), hypertension (OR = 2.07; 1.26–3.41), and urolithiasis (OR = 1.97; 95%CI: 1.18–3.27) were factors associated with low eGFR. Conclusions A low population-based prevalence of low eGFR (as a surrogate for CKDu), both in rural and urban settings areas, in the Northern Peru, was found. Low physical activity levels, hypertension and urolithiasis were factors associated with low eGFR. Interventions to prevent CKD cases may be focused on well-known CV risk factors and urolithiasis.

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“…The factors that we found to be associated with impaired kidney function in our study are consistent with those widely reported in literature, and are not related to CKDu. For example, a recent systematic review has reported that combined aerobic and resistance exercise improves renal function, especially among patients with CKD [35]. Hypertension and obstructive nephropathy have been described as main causes of impaired kidney function.…”

Section: Comparison With Previous Studiesmentioning

confidence: 99%

CKD and CKDu in Northern Peru: a cross-sectional analysis under the DEGREE protocol

Ruíz-Alejos

Caplin

Miranda

et al. 2020

Preprint

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Aims: This study estimated the prevalence of low eGFR in those without known hypertension, T2DM or heavy proteinuria as a surrogate marker for chronic kidney disease of unknown cause (CKDu) among adults in the North of Peru. Methods: A cross-sectional study was conducted following the Disadvantaged Populations eGFR Epidemiology (DEGREE) Study protocol. Low eGFR was defined based on a single eGFR ≤ 60 mL/min/1.7 m2 estimated using the CKD-EPI equation. Environmental conditions related to CKDu (i.e. work in agriculture or sugarcane, water source, heat, and pesticide exposure) were evaluated, in addition to traditional risk factors for CKD (i.e. smoking, heavy drinking, physical activity, hypertension, type 2 diabetes mellitus, urolithiasis, among others). Results: A total of 1514 subjects were included in the study, mean age 45.1 (SD: 16.4), and 55.2% were females. Overall, only 26 cases (1.7%; 95%CI: 1.1% − 2.5%) had an eGFR < 60 mL/min/1.7 m2 compatible with CKD definition; when those with hypertension and type-2 diabetes or heavy proteinuria were excluded, according to the DEGREE protocol, the estimate fell to 0.9% (95%CI: 0.4% − 1.5%). Low physical activity levels (OR = 1.99; 95%CI: 1.18–3.34), hypertension (OR = 2.07; 1.26–3.41), and urolithiasis (OR = 1.97; 95%CI: 1.18–3.27) were factors associated with low eGFR. Conclusions: A low population-based prevalence of low eGFR (as a surrogate for CKDu), both in rural and urban settings areas, in the Northern Peru, was found. Low physical activity levels, hypertension and urolithiasis were factors associated with low eGFR. Interventions to prevent CKD cases may be focused on well-known CV risk factors and urolithiasis.

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Effects of combined aerobic and resistance exercise on renal function in adult patients with chronic kidney disease: a systematic review and meta-analysis

Cited by 28 publications

References 31 publications

The Indian Chronic Kidney Disease (ICKD) study: baseline characteristics

The Indian Chronic Kidney Disease (ICKD) study: baseline characteristics

CKD and CKDu in northern Peru: a cross-sectional analysis under the DEGREE protocol

CKD and CKDu in Northern Peru: a cross-sectional analysis under the DEGREE protocol

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