Effects of Combination Treatment With Fk506 and Cyclosporine on Survival Time and Vascular Changes in Renal-Allograft-Recipient Dogs

Ochiai, Takenori; Sakamoto, Kaoru; Gunji, Yoshio; Hamaguchi, K; Isegawa, Naohisa; Suzuki, Taisei; Shimada, Hisaki; Hayashi, Hiroshi; Yasumoto, Atsushi; Asano, Tomohiko; Isono, Kaichi

doi:10.1097/00007890-198908000-00003

Cited by 50 publications

(22 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, workers at Cambridge University reported unacceptable toxicity including widespread arteritis. 10 However, we 8 and Ochiai et al 11 have shown such vascular lesions to be present in non-immunosuppressed dogs after whole organ transplantation and in dogs treated with other agents including cyclosporin. Arteritis has not been a feature in baboons treated with FK 506 9 or in formal toxicology studies.…”

Section: Introductionmentioning

confidence: 69%

See 1 more Smart Citation

Fk 506 for Liver, Kidney, and Pancreas Transplantation

Fung²,

et al. 1989

View full text Add to dashboard Cite

Summary FK 506 was given for immunosuppression in 14 liver recipients. The drug was used in the first 10 cases because the recipients under conventional immunosuppression had rejection, nephrotoxicity, or both. This salvage therapy was successful in 7 of the 10 attempts. 2 of the 10 patients in the original salvage group as well as 4 new patients underwent fresh orthotopic liver transplantation under FK 506 plus low-dose steroids from the outset. None of these 6 patients had rejection although 1 with preexisting cor pulmonale and coronary atherosclerosis died of a myocardial infarction. In addition, 2 of the 14 liver recipients were given cadaveric kidneys, either from the same donor or from a different donor, and a third was given a pancreas as well as a kidney from the liver donor. There were no rejections of the kidney and pancreas grafts, and serious side-effects were not encountered.

show abstract

Section: Introductionmentioning

confidence: 69%

“…5,6,8,11 Our clinical experience so far has not encouraged such combination therapy. The FK 506 may have increased the toxicity of cyclosporin, possibly by raising its blood concentration.…”

Section: Discussionmentioning

confidence: 99%

Fk 506 for Liver, Kidney, and Pancreas Transplantation

Fung²,

et al. 1989

View full text Add to dashboard Cite

show abstract

“…Vascular damage described as "vasculitis" involving medium-sized arteries in the liver, pancreas, and heart was reported in tacrolimus-treated dogs (93). Work done by our colleagues and others raised doubts about the significance of these findings, as vasculitis was found with equal frequency in control animals (94,95). Studies in rats, baboons, and monkeys treated with tacrolimus (59,96) also were unable to reproduce vasculitis lesions.…”

Section: Acute Microvascular Toxicitymentioning

confidence: 90%

“…Studies in rats, baboons, and monkeys treated with tacrolimus (59,96) also were unable to reproduce vasculitis lesions. Arteriolar-sized renal vessels in rats and dogs treated with tacrolimus develop focal medial necrosis, accumulation of eosinophilic inclusions, and juxtaglomerular transformation but not true arteritis (94,97,98). In our opinion, these arteriolar lesions are similar to those reported with dopaminergic and adrenergic drugs and are adequately explained by intense vasospasm (99,100).…”

Section: Acute Microvascular Toxicitymentioning

confidence: 99%

Tacrolimus (FK506)-Associated Renal Pathology

Randhawa¹,

Starzl

Demetris³

1997

Advances in Anatomic Pathology

View full text Add to dashboard Cite

“…20, 28,29,30,53,54,62,63,65 In February 1989 it was used successfully to salvage 8 of 10 liver allograft recipients suffering intractable rejection despite optimal cydosporinebased immunotherapy. 50 Further use for this indication accrued over 200 patients, and was expanded to include recipients of heart, kidney, lung, and pancreas allografts.…”

Section: Initial Clinical Studies With Tacrolimusmentioning

confidence: 99%