Effects of collateral inhibition in a model of the immature rat cerebellar cortex: multineuron correlations

Bernard, Christophe; Axelrad, H.; Giraud, B. G.

doi:10.1016/0926-6410(93)90016-x

Cited by 10 publications

(3 citation statements)

References 68 publications

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“…A large portion of cerebellar research has focused on a particular circuit element, the Purkinje cell (PC), whose axons provide the sole output of the cerebellar cortex. Although much is known about the intrinsic properties of PCs and their synaptic inputs from parallel fibers, climbing fibers, and inhibitory interneurons, remarkably little is known about the prominence and function of PC axon collaterals and their synaptic connections within the cerebellar cortex (Bernard and Axelrad, 1993; Bernard et al, 1993; Bornschein et al, 2013; Watt et al, 2009). Prominent collaterals would be a major deviation from the feedforward circuitry of the cerebellar cortex, with its main flow of signals from mossy fibers (MFs) through granule cells (grCs) to PCs (Eccles et al, 1967; Marr, 1969).…”

Section: Introductionmentioning

confidence: 99%

“…In p9 mice, PCs have prominent collaterals that provide the primary source of inhibition to other PCs and can mediate travelling waves of activity (Watt et al, 2009). Several studies reported that some PCs have collaterals in juveniles (p30) and adults (≥ p90) (Bernard et al, 1993; Bishop, 1982; Crook et al, 2007; Hawkes and Leclerc, 1989; Larramendi and Lemkey-Johnston, 1970; O’Donoghue and Bishop, 1990), but their prevalence and targets remain largely unknown. Recent work has found functional PC to LC connections in p18–25 animals (Hirono et al, 2012), but connections to other interneuron types or PCs have not been described, and it was hypothesized that PC to PC connections are only functional in young animals (Watt et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Purkinje Cell Collaterals Enable Output Signals from the Cerebellar Cortex to Feed Back to Purkinje Cells and Interneurons

Witter

Rudolph

Pressler

et al. 2016

Neuron

128

121

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Summary Purkinje cells (PCs) provide the sole output from the cerebellar cortex. Although PCs are well characterized on many levels, surprisingly little is known about their axon collaterals and their target neurons within the cerebellar cortex. It has been proposed that PC collaterals transiently control circuit assembly in early development, but it is thought that PC to PC connections are subsequently pruned. Here, we find that all PCs have collaterals in young, juvenile and adult mice. Collaterals are restricted to the parasagittal plane, and most synapses are located in close proximity to PCs. Using optogenetics and electrophysiology we find that in juveniles and adults PCs make synapses onto other PCs, molecular layer interneurons and Lugaro cells, but not onto Golgi cells. These findings establish that PC output can feed back and regulate numerous circuit elements within the cerebellar cortex and is well suited to contribute to processing in parasagittal zones.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Purkinje Cell Collaterals Enable Output Signals from the Cerebellar Cortex to Feed Back to Purkinje Cells and Interneurons

Witter

Rudolph

Pressler

et al. 2016

Neuron

128

121

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show abstract

“…PC feedback via collaterals that are restricted to parasagittal planes is another noteworthy regional specialization ( Witter et al, 2016 ). In addition to sending an axon to the deep cerebellar nuclei, each PC axon has a collateral that inhibits PCs ( Bernard and Axelrad, 1993 ; Bernard et al, 1993 ; Bornschein et al, 2013 ; de Solages et al, 2008 ; Orduz and Llano, 2007 ; Watt et al, 2009 ; Witter et al, 2016 ) and several types of inhibitory interneurons in the cerebellar cortex ( Crook et al, 2007 ; Hirono et al, 2012 ; Witter et al, 2016 ). In some regions, PCs make extensive contacts within the granular layer and inhibit GrCs ( Guo et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Purkinje cell outputs selectively inhibit a subset of unipolar brush cells in the input layer of the cerebellar cortex

Guo

Rudolph

Neuwirth

et al. 2021

eLife

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Circuitry of the cerebellar cortex is regionally and functionally specialized. Unipolar brush cells (UBCs), and Purkinje cell (PC) synapses made by axon collaterals in the granular layer, are both enriched in areas that control balance and eye movement. Here, we find a link between these specializations in mice: PCs preferentially inhibit metabotropic glutamate receptor type 1 (mGluR1)-expressing UBCs that respond to mossy fiber (MF) inputs with long lasting increases in firing, but PCs do not inhibit mGluR1-lacking UBCs. PCs inhibit about 29% of mGluR1-expressing UBCs by activating GABAA receptors (GABAARs) and inhibit almost all mGluR1-expressing UBCs by activating GABAB receptors (GABABRs). PC to UBC synapses allow PC output to regulate the input layer of the cerebellar cortex in diverse ways. Based on optogenetic studies and a small number of paired recordings, GABAAR-mediated feedback is fast and unreliable. GABABR-mediated inhibition is slower and is sufficiently large to strongly influence the input-output transformations of mGluR1-expressing UBCs.

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Computational Model of a Central Pattern Generator

Cataldo¹,

Byrne²,

Baxter³

2006

Computational Methods in Systems Biology

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The buccal ganglia of Aplysia contain a central pattern generator (CPG) that mediates rhythmic movements of the foregut during feeding. This CPG is a multifunctional circuit and generates at least two types of buccal mo- tor patterns (BMPs), one that mediates ingestion (iBMP) and another that medi- ates rejection (rBMP). The present study used a computational approach to ex- amine the ways in which an ensemble of identified cells and synaptic connections function as a CPG. Hodgkin-Huxley-type models were developed that mimicked the biophysical properties of these cells and synaptic connec- tions. The results suggest that the currently identified ensemble of cells is in- adequate to produce rhythmic neural activity and that several key elements of the CPG remain to be identified

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Effects of collateral inhibition in a model of the immature rat cerebellar cortex: multineuron correlations

Cited by 10 publications

References 68 publications

Purkinje Cell Collaterals Enable Output Signals from the Cerebellar Cortex to Feed Back to Purkinje Cells and Interneurons

Purkinje Cell Collaterals Enable Output Signals from the Cerebellar Cortex to Feed Back to Purkinje Cells and Interneurons

Purkinje cell outputs selectively inhibit a subset of unipolar brush cells in the input layer of the cerebellar cortex

Computational Model of a Central Pattern Generator

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